Development of instrument measuring the cerebral blood volume and oxygenation noninvasively with multi-point near infrared spectroscopy
| Project/Area Number |
03557046
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOSHIOKA Hiroshi Kyoto Prefectural University of Medicine Department of Pediatrics Assistant Professor, 医学部, 講師 (50128724)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Koichi Otsuka Electronics Company Developmental Manager, 部長
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | Near infrared / Multi-point method / Cerebral blood volume / Oxygenation / Noninvasive measurement / Neonate / Brain |
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| Research Abstract |
1. We built a prototype instrument providing absolute values of cerebral blood volume and its oxygenation noninvasively using near infrared spectroscopy with multi-point method. Light emissing diodes of 3 wavelengths (705, 810, and 880nm) were used and equisions obtained from hypoxic experiments of rat brain were adapted for the measurement of oxygen saturation.
2. When cerebral blood saturation was measured in an infant with tetoragy of Fallot, the value was higher than that of arterial blood, thus indicating that tissue backgroud is different between human and rat brain. Then we recalculated and obtained new equisions from data in dead human infants.
3. We measured brain hemoglobin concentration in 10 normal full-term infants. The mean value was 42.5 %absorption, which is equivalent to 3.69ml/100g. This seems to be a very reasonable value of cerebral blood volume in full-term infants.
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Report
(3 results)
Research Products
(21 results)
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[Publications] Iino,S., Yoshioka,H., Osamura,T., Goma,H., Okano,S., Sawada,T., Kusunoki,T.: "Chronic cerebral lesions of mice following neonatal severe hemorrhagic hypoxic-ischemic encephalopathy." Brain Dysfunction. 4. 155-162 (1991)
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「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Yoshioka,H., Papadopoulos,M.D., Younkin,D.P., Chance,B., Mitsufuji,N., Sawada,T.: "Metabolic kinetics." No To Hattatsu (in Japanese). 24. 159-163 (1992)
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Related Report
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[Publications] Yoshioka,Hasegawa,Matsuo,Y., Hirai,K., Kawase,S., Morioka,H., Sawada,T., Oono,Y., Hirao,K., Oka,K.: "Quantitative measurements of cerebral blood volume in neonates by near-infrared spectroscopy with multi-points method: a preliminary report." Igaku No Ayumi (in Japanese).
Description
「研究成果報告書概要(欧文)」より
Related Report
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