| Project/Area Number |
03557049
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Osaka University |
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Principal Investigator |
HORI Shinichi Osaka University, Department of Radiology, Assistant Professor, 医学部, 講師 (50135711)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hironobu Osaka University Department of Radiology, Associate professor, 医学部, 助教授 (00116071)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥16,300,000 (Direct Cost: ¥16,300,000)
Fiscal Year 1992: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1991: ¥14,800,000 (Direct Cost: ¥14,800,000)
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| Keywords | Embolization / Embolic Agent / Angiography / Aretiovenous Malformation |
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| Research Abstract |
Embolic agents which are clinically available at present have some drawbacks such as toxicity, catheter gluing, lack of opacity, and so on. We are trying to solve these problems using a new substance. Two kinds of super absorbent polymers(SAPs), acrylic acid polymer sodium salt(SAP-1) and acrylic acid and vinyl alcohol copolymer(SAP-2) were investigated as an arterial embolic material. SAP-1 and SAP-2 absorb 100 and 60 times their weight in saline, respectively, within a short period. Two materials are filtrated and divided into three groups according to their particle size. SAP-1 particles are of white amorphous shape. The main difference of SAP-1 and SAP-2 is fragility when they are swollen. These two substances do not have any known immunogenicity or acute toxicity. SAP-1 absorbs more than 100 times it own weight in serum. SAP-2 microsphere swells in the serum up to 4 times of its original size. These materials suspended by an oily contrast material or a water soluble ionic contrast material were evaluated in vitro study using an AVM model which was composed of a plastic syringe and various sizes of polyurethane sponges. SAPs worked sufficiently as embolic materials in the AVM model. SAPs particles suspended in an oily contrast material flow with blood into the peripheral. Contrast material which coated the agent is washed out by the blood stream. Particles reached at the peripheral part absorb the serum and work as the embolic agent. The embolic effect depended upon the particle size and the quantity and concentration of the suspension. The embolized part was clearly seen due to the retention of the contrast material. This material is a promising agent for AVM and neoplasms embolization.
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