| Project/Area Number |
03557058
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKANO Hisateru National Cardiovascular Center, Research Institute, Dept of Artificial Organs., Director, 人工臓器部, 部長 (60028595)
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| Co-Investigator(Kenkyū-buntansha) |
AKUTSU Tetsuzo Kanazawa Medical University Cardiac Surgery, Professor, 胸部心臓血管外科, 教授 (40150221)
KITO Yoshitsugu National Cardiovascular Center, Hospital, Division of Cardiac Surgery, Director, 心臓外科, 部長
AKAGI Haruhiko National Cardiovascular Center, Research Institute, Dept of Artificial Organs.St, 人工臓器部, 室員 (90231802)
NAKATANI Takeshi National Cardiovascular Center, Research Institute, Dept of Biomedical Engineeri, 生体工学部, 室長 (60155752)
TAENAKA Yoshiyuki National Cardiovascular Center, Research Institute, Dept of Artificial, Division, 人工臓器部, 室長 (00142183)
木下 正之 国立循環器病センター研究所, 人工臓器部, 室員 (00183301)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 1993: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1991: ¥6,500,000 (Direct Cost: ¥6,500,000)
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| Keywords | membrane oxygenator / artificial heart / heart-lung failure / ECMO / bridge use / heart-lung transplantations / antithronbogenicity / hybrid tissue / ブリッヂ使用 |
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| Research Abstract |
As the heart and lung frequently fail simultaneously due to the extensive interaction of these closely related organs, it has been expected to develop such a device as to support these organs at the same time. On the basis of this back ground, we have developed a novel assist system for long-term cardiopulmonary support ; an integrated artificial heart-lung device (IAHLD). The IAHLD consists of a compact oxygenator and two pneumatic pusher-plate type artificial hearts. The oxygenator is made of two layred non-porous membrane hollow fibers in which an ultrathin dense layr formed at the blood contacting surface prevents serum leakage. The fibers are potted in a cylindrical polyurethane potting (phi60 mm X 70 mm) which also serves as a housing. The artificial heart has an inlet (or outlet) port with a Bjork-Shiley valve and a coupler of 60 mm in diameter. The artificial heart are coupled to each and of the oxygenator with the coupler ; thus all components are incorporated. With this special structure, we intended to avoid low flow areas, which causes thrombus formation and gas exchange deterioration. The gas transfer performance of the prototype device (gas exchange area =1.5m^2, priming volume = 400 ml) was 300 ml/min for oxygen and 250 ml/min for carbon dioxide at a blood flow rate of 5 L/min. Venoarterial bypass using the prototype device could satisfactory replace the total cardiopulmonary function in a nonfunctioning heart-lung model of a goat weighing 60 kg. During 6 hours of pumping, hemodynamic parameters of the goat was maintained fairly stable and blood gas data was kept above 300 mmHg for PaO_2 and below 30 mmHg for PaCO_2. We are also developing a technique for thromboresistant surface treatment : covalent heparin bonding technique. Although this research is still premature, we believe that we can make it practical in a near future.
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