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Development of long term use menbrane oxygenator built-in artificial heart

Research Project

Project/Area Number 03557058
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

TAKANO Hisateru  National Cardiovascular Center, Research Institute, Dept of Artificial Organs., Director, 人工臓器部, 部長 (60028595)

Co-Investigator(Kenkyū-buntansha) AKUTSU Tetsuzo  Kanazawa Medical University Cardiac Surgery, Professor, 胸部心臓血管外科, 教授 (40150221)
KITO Yoshitsugu  National Cardiovascular Center, Hospital, Division of Cardiac Surgery, Director, 心臓外科, 部長
AKAGI Haruhiko  National Cardiovascular Center, Research Institute, Dept of Artificial Organs.St, 人工臓器部, 室員 (90231802)
NAKATANI Takeshi  National Cardiovascular Center, Research Institute, Dept of Biomedical Engineeri, 生体工学部, 室長 (60155752)
TAENAKA Yoshiyuki  National Cardiovascular Center, Research Institute, Dept of Artificial, Division, 人工臓器部, 室長 (00142183)
木下 正之  国立循環器病センター研究所, 人工臓器部, 室員 (00183301)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥12,300,000 (Direct Cost: ¥12,300,000)
Fiscal Year 1993: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1992: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 1991: ¥6,500,000 (Direct Cost: ¥6,500,000)
Keywordsmembrane oxygenator / artificial heart / heart-lung failure / ECMO / bridge use / heart-lung transplantations / antithronbogenicity / hybrid tissue / ブリッヂ使用
Research Abstract

As the heart and lung frequently fail simultaneously due to the extensive interaction of these closely related organs, it has been expected to develop such a device as to support these organs at the same time. On the basis of this back ground, we have developed a novel assist system for long-term cardiopulmonary support ; an integrated artificial heart-lung device (IAHLD). The IAHLD consists of a compact oxygenator and two pneumatic pusher-plate type artificial hearts. The oxygenator is made of two layred non-porous membrane hollow fibers in which an ultrathin dense layr formed at the blood contacting surface prevents serum leakage. The fibers are potted in a cylindrical polyurethane potting (phi60 mm X 70 mm) which also serves as a housing. The artificial heart has an inlet (or outlet) port with a Bjork-Shiley valve and a coupler of 60 mm in diameter. The artificial heart are coupled to each and of the oxygenator with the coupler ; thus all components are incorporated. With this special structure, we intended to avoid low flow areas, which causes thrombus formation and gas exchange deterioration. The gas transfer performance of the prototype device (gas exchange area =1.5m^2, priming volume = 400 ml) was 300 ml/min for oxygen and 250 ml/min for carbon dioxide at a blood flow rate of 5 L/min. Venoarterial bypass using the prototype device could satisfactory replace the total cardiopulmonary function in a nonfunctioning heart-lung model of a goat weighing 60 kg. During 6 hours of pumping, hemodynamic parameters of the goat was maintained fairly stable and blood gas data was kept above 300 mmHg for PaO_2 and below 30 mmHg for PaCO_2. We are also developing a technique for thromboresistant surface treatment : covalent heparin bonding technique. Although this research is still premature, we believe that we can make it practical in a near future.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Tatsumi E,et al.: "An integrated artificial heart-lung device." Trans Am Soc Artif Intern Organs. 37. M310-M311 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 赤城治彦 他: "肺または心肺移植へのbridge useを目的とした一体型心肺補助装置の開発" 膜型肺. 16. 59-62 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 高野久輝 他: "膜型肺-ハードウェアの現況と展望-" 膜型肺. 16. 98-102 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 馬場雄造 他: "長期使用を目的とした人工肺の開発-ヘパリンコーティング人工肺の試作と性能評価-" 膜型肺. 16. 44-48 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tatsumi E, et al.: "An integrated artificial heart-lung device." Trans Am Soc Artif Intern Organs. 37. M310-M311 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 高野久輝、赤城治彦: "膜型肺-ハードウェアの現況と展望-" 膜型肺. 16. 98-102 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 赤城治彦、高野久輝 他: "肺または心肺移植へのbridge useを目的とした一本型心肺補助装置の開発" 膜型肺. 16. 59-62 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 馬場雄造、高野久輝 他: "長期使用を目的とした人工肺の開発-ヘパリンコーティング人工肺の試作と性能評価-" 膜型肺. 16. 44-48 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tatsumi E,Takano H,et al: "An Integrated Artificial Heart-Lung Device" Trans Am Soc Artif Intern Organs. 37. M310-M311 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 赤城 治彦、高野 久輝、他: "肺または心肺移植でのBridge Useを目的とした一体型心肺補助装置の開発" 膜型肺. 15. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高野 久輝、赤城 治彦: "膜型人工肺ーハードウエアの現況と展望ー" 膜型肺. 15. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 巽 英介,高野 久輝他10名: "長期間使用を目的とした人工肺の研究開発と評価" 人工臓器. 20(2). 371-376 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Tatsumi E.,Takano H.,et al: "An Integrated Artificial Heart-Lung Device" ASAIO Transactions. 37(3). M310-M311 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 中谷 武嗣,高野 久輝他9名: "腹壁内埋込み型左心補助人工心臓に関する基礎的検討" 人工臓器. 20(4). 1336-1340 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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