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Articular Cartilage Formation by Continuous Joint Movement with External Fixato

Research Project

Project/Area Number 03557062
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

ODA Hiromi (1992-1993)  The University of Tokyo, Medical School, Ass.Prof, 医学部, 講師 (60101698)

落合 直之 (1991)  東京大学, 医学部(病)・整形外科, 講師 (30134563)

Co-Investigator(Kenkyū-buntansha) OKAZAKI Hiroshi  Tsukuba Univ., of Tokyo, Medical School, Instr., 医学部, 助手 (30241988)
OCHIAI Naoyuki  Tsukuba Univ., Medical School, Ass.Prof, 医学部, 助教授 (30134563)
NAGAMURA Kozo  The University of Tokyo, Medical School, Ass.Prof, 医学部, 助教授 (60126133)
NAGANO Akira  The University of Tokyo, Medical School, Ass.Prof, 医学部, 助教授 (30111537)
KUROKAWA Takahide  The University of Tokyo, Medical School, Professor, 医学部, 教授 (90010298)
福井 尚志  東京大学, 医学部(病), 助手
田尻 康人  東京大学, 医学部(病), 医員
木村 雅弘  東京大学, 医学部(病), 医員
酒井 宏哉  東京大学, 医学部(病)・整形外科, 助手 (40205711)
中村 茂  東京大学, 医学部(病)・整形外科, 助手 (10189037)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥17,100,000 (Direct Cost: ¥17,100,000)
Fiscal Year 1993: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥15,200,000 (Direct Cost: ¥15,200,000)
KeywordsCartilage formation / External fixator / Continuous Joint Movement / Distraction force / 創外固定器 / 関節形成術 / 圧迫力 / 関節造成システム / CPM / 軟骨形成 / 関節形成 / 持続他動運動
Research Abstract

It is generaly accepted that cartilage regeneration is very difficult. The purpose of this research project is to develop the methods for cartilage regeneration. We performed three basic type of experiments.
Experiment 1. After all of the cartilage material was removed from rabbit knee joints, continuous passive movement was applied to the joints by using external fixators under contact, or non-contact, conditions. Eight weeks later, hyaline cartilage were made only under non-contact conditions.
Experiment 2.3 mm diameter defects were created surgically in the femoral condyles of rabbit knee joints. External fixators were attached around the joints and active movement was allowed under both contact, and non-contact, conditions. Four weeks later, cartilage regeneration had occurred, only under non-contact conditions.
Experiment 3. Distraction force was applied to rabbit knee joints, using external fixators. Cartilage degeneration occurred nine weeks later.
From these results, we conclude, that continuous movement, under non-contact condition, is necessary for cartilage regeneration, and commpressive force is necessary for maintaining normal cartilage function.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Shin-Chieh Hunger al.: "Effect of Contimous Distraction on Cartilage in a Moving Joint" Journal of Orthopaedic Research. 15. 381-390 (1997)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Shin-Chieh Hung et al.: "Effect of Continuous Distraction on Cartilage in a Moving Joint" J.Orthop.Research. 15. 381-390 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 織田 弘美他: "骨細胞の老化" 整形外科. 43. 1046-1052 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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