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Development of artificial Osteo-chondral composite material

Research Project

Project/Area Number 03557064
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

OKA Masanori  Kyoto Univ. Res. Cent. for Biomed. Engr., Artificial Locomotive Systems, Professor, 生体医療工学研究センター, 教授 (20088537)

Co-Investigator(Kenkyū-buntansha) FUJISAWA A  Kyocera Comp. Ltd., Manager, バイオセラム事業部
TSUTSUMI S  Kyoto Univ. Res. Cent. for Biomed. Engr., Medical System Engineering, Ass. Profe, 生体医療工学研究センター, 助教授 (00028739)
IKEUCHI K  Kyoto Univ. Res, Cent. for Biomed. Engr., Bioengineering, Professor, 生体医療工学研究センター, 教授 (30026223)
IKADA Y  Kyoto Univ. Res. Cent. for Biomed. Engr., Biomaterials, Professor, 生体医療工学研究センター, 教授 (00025909)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥15,700,000 (Direct Cost: ¥15,700,000)
Fiscal Year 1992: ¥7,000,000 (Direct Cost: ¥7,000,000)
Fiscal Year 1991: ¥8,700,000 (Direct Cost: ¥8,700,000)
KeywordsArtificial cartilage / composite material / Porous artifial bone / Lubrication / Biocompatibility / Load-bearing
Research Abstract

We investigated and compared biomechanics of natural and artificial joints. The most important functions of the joints rely on excellent lubrication and uniform distribution of impact loads on the underlying bones. As to the lubrication, we measured dynamic changes of the joint space optically and verified the existence of fluid film lubrication in natural joints. From the aspect of fluid film lubri-cation, ultra high molecular weight polythylene(UHMWPE)is not as good a material as polyvinyl alcohol(PVA-H)and articular cartilage. The momentary stress transmitted though the specimens revealed that sub-chondral cancellous bones played the most important role and the UHMWPE had a highter peak stress and ashorter durations of sustained stress than articular cartilage and PVA-H, suggesting a worse dampingeffect. From the results of finite element method (FEM) analysis, intramedullary stem fixation mightnot avoid stress shielding. In artificial joints in the future, it is desirable to preserve as muchsubchondral cancellous bone as possible and to replace the involved joint surface with materials whose mechanical properties are similar to those of articular cartilage. We examined biocompatibility of this material by implanting them into dog's knee joints and confirmed good biocompatibility. In order to fix the materials firmly to the been, we first infiltrate a PVA solution into the pores of porus alumina and bind these two materials by gelling the PVA. We implated this artificial osteochondral composite material into the patellar groove of a rabbit femur. The histological findings of the undecalcified tissue sections revealed considerable new bone ingrowth into the pores of alumina, just two weeks after the operation. Although some problems still remain to be solved, PVA-Hseems to be a very interesting and promising material which meets the requirements of artificial articular cartilage.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (77 results)

All Other

All Publications (77 results)

  • [Publications] J.Delecrin: "Measurement of Synovial Fluid Volume : A New Dilution Method Adapted to Fluid Permeation from the Synovial Cavity." J.Rheumatoloqy. 19(11). 1746-1756 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.OKA: "Biomechanics of Natural and Artificial Joints." Biomechanics in Orthopedics. 282-298 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.OKA: "Low wear Rate of UHMWPE Against Zirconia Ceramic(Y-PSZ)." Bioceramics. 5. 373-379 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.OHURA: "Bioactivity of Cao Sio glasses added with various ions." J.Materials Science. 3. 95-100 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.SHIMIZU: "Time Dependent Changes in the Mechanical Pro-perties of Zirconia Ceramics." Bioceramics. 5. 353-359 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.MATSUDA: "Severe Metallosis Observed 17 Years after Re-Placement of the Knee with a Tumor Prosthesis:A Case Report." J.long-term effects of Med.Implamts.1. 295-303 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.MATSUSUE: "In vitro and in vivo studies on bioabsorbable ultra-high-strength poly(L-lactide)rods." J.of Biomedical Materials Research. 26. 1553-1567 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 外村 孝次: "関節面の接触を考慮した応力解析-表面置換型人工股関節のデザインについて-" 生体材料. 10(3). 122-136 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究1-音響加振式損失係数測定装置の試作-" 生体材料. 10(6). 311-318 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第4報)" 整形外科バイオメカニクス. 13. 343-347 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機構(第4報)" 整形外科バイオメカニクス. 13. 375-380 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "骨軟骨接合部の力学的結合について" 整形外科バイオメカニクス. 13. 299-304 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 池内 健: "人工股関節の潤滑状態" 整形外科バイオメカニクス. 13. 327-330 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.TAKAHASHI: "Changes of intraosseous Vasculature and peri-vascular bone to ssue following different do-ses or IOR." Strahlentherap.Onkol.168. 461 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.YOSHII: "Glass-Ceramic implant in Acetabular Bome Dere-ct:An Experimental Study." J.appl Beomaterials. 3. 245-249 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "人工関節軟骨-〔誌説〕" 日本リウマチ関節外科学会雑誌. 11(3). 209-210 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "生体関節と人工関節のバイオメカニクス(教育研修講演)" 日本整形外科学会誌. 66(8). S1323 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 木次 敏明: "AWガラスセラミックスと骨との結合に対するEHDPの影響について(第2報)" 日本整形外科学会誌. 66(8). S2111 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 清水 光一郎: "ジルコニアの経時的変化" 日本整形外科学会誌. 66(8). S1124 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "人工関節軟骨の開発(第5報)" 日本整形外科学会誌. 66(8). S1134 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 高橋 忍: "実験的術中照射における末梢神経の放射的障害" 日本整形外科学会誌. 66(8). S1192 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 松田 康孝: "A-Wガラスセラミックをボトムコーティングした人工股関節に関する研究" 日本整形外科学会誌. 66(8). S1279 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 木次 敏明: "ハイドロオキシアパタイト、トライカルシウムフォスフェイトと骨との結合機序について-EHDPを用いての研究" 66(8). S1119 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "有機系材料 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "除放性薬剤と整形外科における応用 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "縫合糸 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "止血材料と接着材料 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "人工軟骨とその将来 マルホ整形外科整形外科セミナー第93集(No.1022)" マルホ, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 岡 正典: "骨格系人工材料の革新 第23回日本医学会総会会誌III" 日本医学会総会, (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Development of an artificial articular cartilage." Clin. Materials. 6. 361-381 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Noguchi: "Poly(Vinyl Alchol-Hydrogel as an artificial articular cartilage :Evaluation of Biocompatibility." J. app. Biomaterials. 2. 101-107 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J.Delecrin: "Measurement of Synovial fluid volume." J. Rheuma.19. 1746-1752 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Y.Matsusue: "In vitro and in vivo studies on Bioresorbable ultra-high strength poly (L-Lactide)." J. Biomed. Mat. Res.26. 1553-1567 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Low wear rate of UHMWPE against Zirconia ceramic(Y-PSZ)." Bioceramics. 5. 373-379 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Tonomura: "Stress analysis considering the contact of joint surface." Biomaterial(In Japanese). 10. 122-136 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Lubrication of natural and artificial joints(Fourth Report).(In Japanese)" Orthopedic Biomechanics. 13. 375-380 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Load bearing mechanism of natural and artificial joint(Fourth report).(In Japanese)" Orthopedic Biomachanics. 13. 343-347 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Development of an artificial articular cartilage(Fifth Report).(In Japanese)" J. Jap. Orthop. Ass. 66. S1279 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Biomechanics of natural and artificial joint." Biomechanics in Orthopedics eds. by Niwa et al.Springer Verl.282-298 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Polymer materials. (In Japanese)" KANEHARA SHUPPAN Manual of Orthopedic Biomaterials ed. by T.Yamamuro. 57-62 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Oka: "Artificial joints and Biomaterials." "Artificial joints and Biomaterial in Orthopedic Surgery" ed. by M.Oka Medical View Ltd.1-18 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J.Delecrin: "Measurement of Synovial Fluid Volume:A New Dilution Method Adapted to Fluid Permeation from the Synovial Cavity." J.Rheumatology. 19(11). 1746-1756 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Oka: "Biomechanics of Natural and Artificial Joints." Biomechanics in Orthopedics. 282-298 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.Oka: "Low wear Rate of UHMWPE Against zirconia Ceramic(Y-PSZ)." Bioceramics. 5. 373-379 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Ohura: "Bioactivity of CaO SiO_2 glasses added with various ions." J.Materials Science. 3. 95-100 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Shimizu: "Time Dependent Changes in the Mechanical Pro-parties of Zirconia Ceramics." Bioceramics. 5. 353-359 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsuda: "Severe Metallosis Observed 17 Years after Replacement of the Knee with a Tumor Prosthesis:A Case Report." J.long-term effects of Med.Implamts. 1. 295-303 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y.Matsusue: "In vitro and in vivo studies on bioabsorbable ultra-high-strength poly(L-lactide)rods." J.of Biomedical Materials Research. 26. 1553-1567 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 外村 孝次: "関節面の接触を考慮した応力解析ー表面置換型人工股関節のデザインについてー" 生体材料. 10(3). 122-136 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 速水 尚: "関節材料の衝撃吸収能に関する研究1ー音響加振式損失係数測定装置の試作ー" 生体材料. 10(6). 311-318 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第4報)" 整形外科バイオメカニクス. 13. 343-347 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機構(第4報)" 整形外科バイオメカニクス. 13. 375-380 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "骨軟骨接合部の力学的結合について" 整形外科バイオメカニクス. 13. 299-304 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 池内 健: "人工股関節の潤滑状態" 整形外科バイオメカニクス. 13. 327-330 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Takahashi: "Changes of intraosseous vasculature and peri-vascular bone to ssue following different doses of IOR." Strahlentherap.Onkol.168. 461- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Yoshii: "Glass-Ceramic implant in Acetabular Bone Defect:An Experimental Study." J.appl.Biomaterials. 3. 245-249 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工関節軟骨-〔誌説〕" 日本リウマチ関節外科学会雑誌. 11(3). 209-210 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節のバイオメカニクス(教育研修講演)" 日本整形外科学会誌. 66(8). S1323- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木次 敏明: "AWガラスセラミックスと骨との結合に対するEHDPの影響について(第2報)" 日本整形外科学会誌. 66(8). S2111- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 清水 光一郎: "ジルコニアの経時的変化" 日本整形外科学会誌. 66(8). S1124- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工関節軟骨の開発(第5報)" 日本整形外科学会誌. 66(8). S1134- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 高橋 忍: "実験的術中照射における末梢神経の放射的障害" 日本整形外科学会誌. 66(8). S1192- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 松田 康孝: "A-Wガラスセラミックをボトムコーティングした人工股関節に関する研究" 日本整形外科学会誌. 66(8). S1279- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 木次 敏明: "ハイドロオキシアパタイト、トライカルシウムフォスフェイトと骨との結合機序についてーEHDPを用いての研究" 66(8). S1119- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "有機系材料 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "徐放性薬剤と整形外科における応用 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "縫合系 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "止血材料と接着材料 整形外科医用材料マニュアル" 金原書店, 224 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "人工軟骨とその将来 マルホ整形外科整形外科セミナー第93集(No.1022)" マルホ, (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 岡 正典: "骨格系人工材料の革新 第23回日本医学会総会会誌III" 日本医学会総会, (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] M.OKa: "Development of an atrificial articular catilage" J.clinical Material. 6. 361-381 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] T.Noguchi: "PVA Hydrogel as an artificial articular cartilage:Evalnation of Biocompatibility" J.app.Biomaterial. 2. 101-107 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の潤滑機構(第3報)" 整形外科バイオメカニクス. 12. 33-36 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] 岡 正典: "生体関節と人工関節の負荷機構(第3報)" 整形外科バイオメカニクス. 12. 47-51 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] P.Kumar: "Low wear rate of UHMWPE against zirconia ceramic (Y-PSZ)" J.Biomed.Mat.Res.25. 813-828 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.OKa: "Development of artificial Osteochondral composite material" Transactions of the combined meeting of Orthopedic Research Societies of USA,Japan,Canada,October 21-23,. (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 岡 正典: "人工関節.バイオマテリアル図説整形外科診断治療講座第15巻(岡正典編集)" メジカルビュ-社, 259 (1990)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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