| Project/Area Number |
03557082
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
補綴理工系歯学
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AOKI Hideki Tokyo Med.& Dent.Univ.Med.& Dent.Eng.Prof., 医用器材研究所, 教授 (80014166)
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| Co-Investigator(Kenkyū-buntansha) |
ENOMOTO Shouji Tokyo Med.& Dent.Univ.Sec.Oral Surg.Prof., 歯学部・第二口腔外科, 教授 (40013940)
IMAI Youji Tokyo Med.& Dent.Univ.Med.& Dent.Eng.Prof., 医用器材研究所, 教授 (50013975)
NAKAMURA Satoshi Tokyo Med.& Dent.Univ.Med.& Dent.Eng.Res.Assis., 医用器材研究所, 助手 (40227898)
OHGAKI Masataka Tokyo Med.& Dent.Univ.Med.& Dent.Eng.Res.Assis., 医用器材研究所, 助手 (50223748)
AKAO Masaru Tokyo Med.& Dent.Univ.Med.& Dent.Eng.Assis.Prof., 医用器材研究所, 助教授 (50143607)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 1993: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 1991: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | hydroxyapatite / polymers / Hydroxyapatite・composite / hydroxyapatite・cellulose / hydroxyapatite・Bis-GMA / hydroxyapatite microcrystals・silicone rubber / good biocompatibility / high fracture toughness / 複合傾斜材料 / アミノ酸の吸着 / 多孔質アパタイト / Bis-GMA / 多孔質アパタイト・Bis-GMA複合材料 / 曲げ・圧縮強度測定 / 細胞増殖率 / アパタイト / ポリマ- / 傾斜材料 / 安全性試験 |
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| Research Abstract |
Hydroxyapatite・composite materials were prepared with several polymers. These composite materials were investigated for their mechanical properties and biological safety test. The developed new hydroxyapatite composites consisited of hydroxyapatite・cellulose composite, porous hydroxyapatite・Bis-GMA composite, and hydroxyapatite microcrystals・silicone rubber composite.
The hydroxyapatite・cellulose composite was handled easily, and the result of animal tests showed this material connected with the new bone directly and a good biocompatibility for long term. The hydroxyapatite・Bis-GMA composite was safety material compared with the Bis-GMA single body which result was determined by the cell reaction test using L-cells. The hydroxyapatite microcrystals・silicone rubber composite was a hard material compared with silicone rubber single body and tensile strength was decleased with the addded amount of hydroxyapatite microcrystals. From the animal test, inflammation was decleased for the 15wt% addition of hydroxyapatite microcrystals.
These three new hydroxyapatite composites had a good biocompatibility as well as hydroxyapatite single body, and covered the defect of hydroxyapatite single body. These new composites were handling easy and high fracture toughness.
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