• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Synthetic Study on Homoisocarbacyclin

Research Project

Project/Area Number 03557092
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionUniversity of Tokyo (1992-1993)
Hokkaido University (1991)

Principal Investigator

SHIBASAKI Masakatsu  University of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30112767)

Co-Investigator(Kenkyū-buntansha) KOGI Kenntaro  Toaeiyo Senior Research, 福島研究所, 主任研究員
SODEOKA Mikiko  University of Tokyo, Faculty of Pharmaceutical Sciences, Research Associate, 薬学部, 助手 (60192142)
笹井 宏明  北海道大学, 薬学部, 助手 (90205831)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1993: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1992: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 1991: ¥4,500,000 (Direct Cost: ¥4,500,000)
KeywordsCarbacyclin / Isocarbacyclin / Chemically Stable Prostacyclin Analog / Inhibitor of platelet aggregation / プロスタサイクリン安定類縁体 / プロスタグランジン / 循環器疾患薬 / ヒドリンダン骨格
Research Abstract

In order to develop a new drug many homoisocarbacyclin analogs have beensynthesized. Anong those1-9, the homoisocarbacyclin amalog 7 has been selected as a candidate for further investigation.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] M.Shibasaki: "A Novel Homoisocarbacyclin Analog with Potent and Long-Lasting Activity" Chem.Pharm.Bull.40. 279-281 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Narita: "An Imroved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4045 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Narita: "Syntheses and Biological Activities of Chemically Stable Prostacyclin Mimics with cis-Bicyclo[4,3,0]nonene Ring System:The Novel Homo-isocarbacyclin Analogues" Bioorganic & Med.Chemistry. 1. 77-118 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Shibasaki, A.Takahashi, T.Aoki, H.Sato, S.Yamada, M.Kudo, K.Kogi, and S.Narita: "A Novel Homoisocarbacyclin Analog with Potent and Long-Lasting Activity"" Chem.Pharm.Bull. 40. 279-281 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Narita, A.Takahashi, H.Sato, T.Aoki, S.Yamada, and M.Shibasaki: "An Improved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4045 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Narita, A.Takahashi, T.Aoki, H.Sato, S.Satoh, S.Yamada, M.Kudo, T.Yamaguchi, K.Kogi, and M.Shibasaki: "Syntheses and Biological Activities of Chemically Stable Prostacyclin Mimics with cis-Bicyclo [ 4,3,0 ]nonene Ring System : The Novel Homoisocarbacyclin Analogues" Bioorganic & Med.Chemistry. 1. 77-118 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] S.Narita: "SYNTHESES AND BIOLOGICAL ACTIVITIES OF CHEMICALLY STABLE PROSTACYCLIN MIMICS WITH cis-BICYCLO[4.3.0]NONENE RING SYSTEM:THE NOVEL HOMOISOCARBACYCLIN ANALOGUES" Bioorganic & Med.Chemistry. 1. 77-118 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] M.Shibasaki: "A Novel Homoisocarbacyclin Analog with Potent and Long-Lasting Activity" Chem.Pharm.Bull.40. 279-281 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S.Narita: "An Improved Method for the Introduction of Carbon-Carbon Triple Bond at C-13 in PG Synthesis" Tetrahedron Lett.33. 4041-4044 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shoji Satoh: "Control of Ring-Junction Stereochemistry via Radical Cyclization.A New Construction of trans-Hydrindans" The Journal of Organic Chemistry. 56. 2278-2280 (1991)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi