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Genetical and biochemical characterizations of hemorrhagic fever with renal syndrome virus infection in mice.

Research Project

Project/Area Number 03558009
Research Category

Grant-in-Aid for Developmental Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionHokkaido University

Principal Investigator

ARIKAWA Jiro  Institute of Immunological Associate Science, Hokkaido University Professor, 免疫科学研究所, 助教授 (10142704)

Co-Investigator(Kenkyū-buntansha) ISEGAWA Yuji  Research Institute for Assistant Microbial Diseases, Osaka Professor University, 微生物病研究所, 助手 (20184583)
ISHIHARA Chiaki  School of Veterinary Professor Medicine, Rakuno Gakuen University, 獣医学科, 教授 (90082172)
YOSHIMATSU Kumiko  Institute of Immunological Research Science, Hokkaido University Assistant, 免疫科学研究所, 教務職員 (90220722)
ITAKURA Chitoshi  Faculty of Veterinary Professor Medicine, Hokkaido University, 獣医学部, 教授 (30021695)
HASHITOMO Nobuo  Faculty of Veterinary Professor Medicine, Hokkaido University, 獣医学部, 教授 (60082103)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥15,400,000 (Direct Cost: ¥15,400,000)
Fiscal Year 1993: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1992: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1991: ¥7,400,000 (Direct Cost: ¥7,400,000)
KeywordsHemorrhagic fever with renal syndrome / Hantavirus / Animal model / Scid mouse / PCR / Virus infection / Animal experiment / Clinical biochemistry / Scidマウス
Research Abstract

1. SCID mice inoculated i.p. with Hantaan virus and Seoul virus developed systemic infection and died after 32 to 38 days post infection.
2. Viral antigen was detected from various organs including kidney. Although no hemorrhagic manifestations was seen in kidney, the SCID mice showed increased level of BUN after infection.
3. RT-PCR followed by Nested-PCR method was established for detecting Hantaan virus genome in various organs in infected mice.
4. SCID mice (21 days post infection) were passively administered with spleen cells which were prepared from normal BALB/c mice. Seven days after the cell transfer, SCID mice began to produce serum antibody to Hantaan virus. In accordance with the appearance of antibody, BUN levels transiently increased. These results suggest the immune response mediated pathology of Hantavirus infection.
These results suggest the possible application of SCID mice as the model for hemorrhagic fever with renal syndrome in human. However, the infected SCID mice did not show any hemorrhagic manifestation nor pathologic changes. Further characterizations with the transfer of immune spleen cells and measurement of cytokines in serum will be required.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (79 results)

All Other

All Publications (79 results)

  • [Publications] Yao,J.-S.: "Antibody-dependent enhancement of hantavirus ifection in macrophge cell lines." Archives of Virology. 122. 107-118 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kobayashi,K.: "Renal lesions in rats infected with Rattus serotype hantavirus (SR-11 strain)." Journal of Veterinary Medicine. B38. 657-664 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mori,F.: "Pathological studies on central nervous tissues of rats infected with Rattus serotype hantaviruses." Journal of Veterinary Medicine. B38. 665-672 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kawamura,K.: "Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses." Acta Virologica. 35. 54-63 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 苅和宏明: "ドブネズミにおける腎症候性出血熱ウイルス感染の疫学的研究" 北海道獣医師会誌. 35. 69-74 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa,J.: "Protective role of antigeni sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa,H.: "Development and application of protein G antibody assay for the detection of antibody to hantavirus." Journal of Virological Methods. 37. 345-354 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yao,J.-S.: "Effect of neutralizing monoclonal antibodies on Hantaan virus infection of the macrophage P388D1 cell line." Japanese Journal of Veterinary Research. 40. 87-97 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Azuma,I.: "Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice." Microbial Infections. 19. 253-263 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isegawa,Y.: "Selective amplification of cDNA sequence from total RNA by cassette-ligation mediated polymerase chain reaction(PCR):Application to sequencing 6.5 kb genome segment of hantavirus strain B-1." Molecular and Cellular Probes. 6. 467-475 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa,J.: "Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大島淳: "PCR法による腎症候性出血熱ウイルスHantaan株の微量検出法" 日本臨床. 50. 305-309 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishihara,C.: "Anti-viral activity of sulfated chitin derivatives against Friend Leukemia and herpes simplex type-1 viruses." Vaccine. 11. 670-673 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimatsu,K.: "Protective immunity of Hantaan virus nucleocapsid protein studied using the baculovirus-expressed proteins." Archives of Virology. 130. 365-376 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoo,Y.-C.: "Comparison of virulence between Seoul type virus strain SR-11 and Hantaan type virus strain 76-118 of hantaviruses in suckling mice." Microbiology and Immunology. 37. 557-562 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimatsu,K.: "Application of recombinant baculovirus expressed hantavirus nucleocapsid protein as a diagnostic antigen inIFA test" Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 有川二郎: "特集腎症候性出血熱(HFRS);最近の話題,免疫学的・診断学的立場から." アニテックス. 5. 277-281 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 伊勢川裕二: "特集腎症候性出血熱(HFRS);最近の話題,腎症候性出血熱ウイルス." アニテックス. 5. 273-276 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa,J.: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido,Japan" Journal of Veterinary Medical Science. 56. 27-32 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa,H.: "Enhancement of infectivity of hantavirus in cell culture by centrifugation." Journal of Virological Method. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa,H.: "Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastern Asia." Virus Research. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kobayashi, K., Itakura, C., Arikawa, J.and Hashimoto, N.: "Renal lesions in rats infect-ed with Rattus serotype hantavirus(SR-11 strain)." Journal of Veterinary Medicine. B38. 657-664 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mori, F., Kobayashi, K., Itakura, C., Arikawa, J., Hashimoto, N.: "Pathologic studies on central nervous tissues of rats infected with Rattus serotype hantavirus(SR-11 strain)." Journal of Veterinary Medicine. B38. 665-672 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kawamura, K., Zhang, X.-K., Arikawa, J., Takashima, I., Dempo, K.and Hashimoto, N.: "Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type Hantaviruses." Acta virologica. 35. 54-63 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa, H., Arikawa, J., Yao, K.-S., Takashima, I., Hashimoto, N.: "Epidemiological studies on wild rats" Hokkaido Jyuishikai Zasshi (in Japanese). 35(3). 69-74 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa, J., Yao, J.-S., Yoshimatsu, K., Takashima, I.and Hashimoto, N.: "Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Azuma, I., Ishihara, C., Iida, J., Yoo, Y.C., Yoshimatsu, K.and Arikawa, J.: "Stimu- lation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice." Microbial Infections Friedman (eds). 253-26.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa, H., Arikawa, J., Takashima, I.and Hashimoto, N.: "Development and application of protein G antibody assy for the detection of antibody to hantavirus." Journal of Virological Methods. 37. 345-354 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yao, J.-S., Kariwa, H., Takashima, I., K., Yoshimatsu, Akikawa, J.and Hashimoto, N.: "Antibody dependent enhancement of Hantavirus infection in macrophage cell lines." Archives of Virology. 122. 107-118 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yao, J.-S., Akikawa, J., Kariwa, H., Yoshimatsu, K., Takashima, I.and Hashimoto, N.: "Effect of neutralizing monoclonal antibodies on Hantaan virus intection of the macrophage P388D1 cell line." Japanese Journal of Veterinary Research. 40. 87-97 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa, J., Yao, J.-S., Yoshimatsu, K., Takashima, I., Hashimoto, N.: "Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ohshima, A., Isegawa, Y.: "Detection of HFRS Hantaan virus RNA sequence by PCR." Nippon Rinsho (in Japanese). 50. 305-309 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isegawa, Y., Sheng, J., Sokawa, Y., Yamanishi, K., Nakagomi, O., Ueda, S.: "Selective amplification mediated polymerase chain reaction (PCR) : Application to sequencing 6.5Kb genome segment of hantavirus strain B-1." Molecular and Cellular Probes. 6. 467-47

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ishihara, C., Yoshimatsu, K., Tsuji, M., Arikawa, J., Saiki, I.and Azuma, I.: "Anti- viral activity of sulfated chitin derivatives against Friend Leukemia and herpes simplex type-1 viruses." Vaccine. 11. 670-673 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimatsu, K., Yoo, Y.-C., Yoshida, R., Ishihara, C., Azuma, I.and Arikawa, J.: "Protective immunity of Hantaan virus necleocapsid and envelope protein studied using the baculovirus-expressed proteins." Archives of Virology. 130. 365-376 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoo, Y.-C., Yoshimatsu, K., Yoshida, R., Azuma, I.and Arikawa, J.: "Comparison of virulence between Seoul type virus strain SR-11 and Hantaantype virus strain 76-118 of hantaviruses in suckling mice." Microbiology and Immunology. 37. 557-562 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshimatsu, K., Arikawa, J.and Kariwa, H.: "Application of recombinant baculovirus expressed hantavirus uncleocapsid protein as a diagnostic antigen in IFA test : cross reactive among three different serotypes of hemorrhagic fever with renal syndrome (HFRS)." Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa, J.: "Hemorrhagic fever with renal syndrome (HFRS) ; Current topics, Immunological and diagnostic study." Laboratory Animal Technology and Science (in Japanese). 5(6). 277-281 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Isegawa, Y.: "Hemorrhagic fever with renal syndrome (HFRS) ; Current topics, Virology of the hemorrhagic fever with renal syndrome virus." Laboratory Animal Technology and Science (in Japanese). 5(6). 273-276 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Arikawa, J.: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido, Japan." Journal Veterinary Medical Science. 56. 27-32 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa, H., Arikawa, J., Takashima, I., Isegawa, Y., Yamanishi, K., Hashimoto, N.: "Enhancement of infectivity of hantavirus in cell culture by centrifugation" Journal of Virological Methods. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Kariwa, H., Isegawa, Y., Arikawa, J., Takashima, I., Ueda, S., Yamanishi, K., Hashimoto, N.: "Comparison of nucleotide sequence of M genome segments among Seoul virus strains isolated from Easten Asia." Virus Research. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yao,J.-S.: "Antibody-dependent enhancement of hantavirus ifection in macrophge cell lines." Archives of Virology. 122. 107-118 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kobayashi,K.: "Renal lesions in rats infected with Rattus serotype hantavirus(SR-11 strain)." Journal of Veterinary Medicine. B38. 657-664 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Mori,F.: "Pathological studies on central nervous tissues of rats infected with Rattus serotype hantaviruses." Journal of Veterinary Medicine. B38. 665-672 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kawamura,K.: "Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses." Acta Virologica. 35. 54-63 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] 苅和宏明: "ドブネズミにおける腎症候性出血熱ウイルス感染の疫学的研究" 北海道獣医師会誌. 35. 69-74 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Arikawa,J.: "Protective role of antigeni sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kariwa,H.: "Development and application of protein G antibody assay for the detection of antibody to hantavirus." Journal of Virological Methods. 37. 345-354 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yao,J.-S.: "Effect of neutralizing monoclonal antibodies on Hantaan virus infection of the macrophage P388D1 cell line." Japanese Journal of Veterinary Research. 40. 87-97 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Azuma,I.: "Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice." Microbial Infections. 19. 253-263 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Isegawa,Y.: "Selective amplification of cDNA sequence from total RNA by cassetteligation mediated polymerase chain reaction(PCR):Application to sequencing 6.5kb genome segment of hantavirus strain B-1." Molecular and Cellular Probes. 6. 467-475 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Arikawa,J.: "Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大島淳: "PCR法による腎症候性出血熱ウイルスHantaan株の微量検出法" 日本臨床. 50. 305-309 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ishihara,C.: "Anti-viral activity of sulfated chitin derivatives against Friend Leukemia and herpes simplex type-1 viruses." Vaccine. 11. 670-673 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshimatsu,K.: "Protective immunity of Hantaan virus nucleocapsid protein studied using the baculovirus-expressed proteins." Archives of Virology. 130. 365-376 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoo,Y.-C.: "Comparison of virulence between Seoul type virus strain SR-11 and Hantaan type virus strain 76-118 of hantaviruses in suckling mice." Microbiology and Immunology. 37. 557-562 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshimatsu,K.: "Application of recombinant baculovirus expressed hantavirus nucleocapsid protein as a diagnostic antigen inIFA test" Journal of Veterinary Medical Science. 55. 1047-1050 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 有川二郎: "特集腎症候性出血熱(HFRS);最近の話題,免疫学的・診断学的立場から." アニテックス. 5. 277-281 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 伊勢川裕二: "特集腎症候性出血熱(HFRS);最近の話題,腎症候性出血熱ウイルス." アニテックス. 5. 273-276 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Arikawa,J.: "Epizootiological studies of hantavirus infection among urban rats in Hokkaido,Japan" Journal of Veterinary Medical Science. 56. 27-32 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kariwa,H.: "Enhancement of infectivity of hantavirus in cell culture by centrifugation." Journal of Virological Method. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Kariwa,H.: "Comparison of nucleotide sequences of M genome segments among Seoul virus strains isolated from Eastern Asia." Virus Research. (in press). (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yao,J.-S.: "Antibody-dependent enhancement of hantavirus infection in macrophage cell lines." Archives of Virology. 122. 107-118 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kobayashi,K.: "Renal lesions in rats intected with Rattus serotype hantavirus(SR-11 strain)." Journal of Veterinary Medicine. B38. 657-664 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mori,F.: "Pathological studies on central nervous tissues of rats infected with Rattus serotype hantavirus(SR-11)." Journal of Veterinary Medicine. B38. 665-672 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kawamura,K.: "Susceptibility of laboratory and wild rodents to Rattus or Apodemus-type hantaviruses." Acta Virologica. 35. 54-63 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 苅和 宏明: "ドブネズミにおける腎症候性出血熱ウイルス感染の疫学的研究" 北海道獣医師会誌. 35. 69-74 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arikawa,J.: "Protective role of antigenic sites onf the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. 126. 271-281 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kariwa,H.: "Develoment and application of protein G antibody assay for the detection of antibody to hantavirus." Journal of Virological Methods. 37. 345-354 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yao,J.-S.: "Effect of neutralizing monoclonal antibodies on Hantaan virus infection of the macrophage P388D1 cell line." Japanese Journal of Veterinary Research. 40. 87-97 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Azuma,I.: "Stimulation of host-defense mechanism with synthetic adjuvants and recombinant cytokines against viral infection in mice." Microbial Infections. 253-263 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Isegawa,Y.: "Selective amplification of cDNA sequence from total RNA by cassetteligation mediated polymerase chain reaction (PCR):Application to sequencing 6.5kb genome segment of hantavirus strain B-1." Molecular and Cellular Probes. 6. 467-475 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshimatsu,K.: "Protective immunity of Hantaan virus nucleocapsid protein studied using the baculovirus-expressed proteins." Archives of Virology. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ishihara,C.: "Anti-viral activity of sulfated chitin derivatives against Friend Murine Leukemia and herpes simplex type-1 viruses." Vaccine. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yao,J.S.: "Antibody dependent enhancement of hantavius infection in macrophage cell lines." Archives of Virology. 122. 107-118 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kobayashi,K.: "Renal lesions in rats infected with Rattus serotype hantarius (SR-11 strain)." Journal of Veterinary Medicine. B38. 657-664 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mori,F.: "Pathological studies on central nervous tissues of rats infected with Rattus serotype Hantavius (SR-11 strain)." Journal of Veterinary Modicine. B38. 665-672 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Arikawa,G.: "Protective role of antigenic sites on the envelope protein of Hantaan virus defined by monoclonal antibodies." Archives of Virology. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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