| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
1) Reaction of 2-(2-oxoalkylseleno)benzazoles 1(X = S, O, N-Me) with allylic Grignard reagents in the presence of BF_3・OEt_2 afforded the corresponding selenoalcohols 2(X = S, O, N-Me ; R^2 = H or Me)which were converted into 1,4-dienes 3 by treatment with bases.
2) The hydride reduction of selenoketones1(X = S,O)gave selenoalcohols4. Benzoxazole derivatives were found to afford syn-selenoalcohols(syn-4) in preference to anti-isomers, While reverse was found for benzthiazole derivatives. On treatment with base, anti-selenoalcohols(anti-4)and syn-selenoalcohols(syn-4)respectively gave E-olefins(E-5)and Z-olefins(Z-5).
3)The reaction of 2-(benzoylalkylseleno)azole 1(X = S or O ; R = R^1 = Ph)with alcohols(R^2OH)in the presence of tributylphosphine gave 2-alkylseleno-azoles 6 in moderate to good yields.
4) When 2-(3-hydroxyalkylseleno)benzoxazoles 7 were treated with KH, selenetanes 8 or spiro compounds 9, the precursor of selenetane, were isolated, depending on the reaction conditions.
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