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Studies on Specialty Biomaterials Carrying Glycochains as Biological Ricognition Signals

Research Project

Project/Area Number 03650746
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 高分子合成
Research InstitutionNagoya University

Principal Investigator

KOBAYASHI Kazukiyo  Nagoya University, Faculty of Agriculture,, 農学部, 助教授 (10023483)

Co-Investigator(Kenkyū-buntansha) OKADA Masahiko  Nagoya University, Faculty of Agriculture, Professor, 農学部, 教授 (20023103)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsSynthetic Polysaccharides / Glycopolymers / Dynamic Aspects of Natural Products Chemistry / Enzyme-Catalysed Synthesis / Fluorinated Polysaccharides / Fine Structure Recognition / Biomimetic Materials / Glycotechnology / 細胞表層多糖 / 糖質高分子化学 / 構造制御合成 / 糖質工学 / 細胞特異性高分子
Research Abstract

Well-defined polymers having carbohydrate chains have been synthesized and applied for cell-specific biomedical materials using the carbohydrates as the key participants in cell-cell recognitions.
(1)Regiosperfcifically fluorinated stereoregular polysaccharides, 3-deoxy-3- fluoro-(1*6)-alpha-D-glucopyranan was synthesized via ring-opening polymerization of anhydro sugar derivative.
(2)beta-Galactosidase-catalyzed synthesis followed by radical polymerization of macromonomer gave a new type of glycopolymers having biologically important N-acetyllactosamine derivatives.
(3)Graft copolymers consiting of synthetic polymer backbone and polysaccharide grafts have been synthesized by phosphorylase-catalyzed synthesis of amylose-substituted styrene derivative and its polymerization.
(4)Amphiphilic graft copolymers having clustered glucosides have been obtained via macromonomers of methacryloyloxyethel alpha-D-glucopyranoside.
(5)A new type of assemblies of liver cells containing hepatocytes, endothelial cells, and Kupffer cells have been constructed by co-culture on lactosecarrying polystyrene as substratum.
(6)Erythrocytes have been fond to attach strongly to a polystyrene derivative carrying reducing-glucose moieties. The dynamic recognition between glucose transporter molecules and reducing glucose moieties is suggested.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (53 results)

All Other

All Publications (53 results)

  • [Publications] M.Goto: "Model study of Hepatocyte Targeting Polymeric Super Molecular Assembly as Drug Carrier" Chem.Lett.1992. 123-126 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tobe: "Receptor-Mediated Formation of Multilayer Aggregates of Primary Cultured Adult Rat Hepatocytes on Lactose-Substituted Polystyrene" Biochem.Biophys.Res.Commun.184. 225-230 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] A.Kobayashi: "Control of Adhesion and Detachment of Parenchymal Liver Cells Using a Lactose-Carrying Polystyrene as Substrate" J.Bioaterials Sci.,Polymer Edn.3. 499-508 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tobe: "Stimulatory Effect of Nonparenchymal Liver Cells on Formation of Multilayer Aggregates of Adult Rat Hepatocytes Cultured on Lactose-Substituted Polystyrene" Commun.Applied Cell Biol.10. 14-21 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kugumiya: "Investigation of Dynamic Behaviors of Asialoglycoprotein Receptors of Hepatocytes Using a Latex Probe Whose Surface Was Coated with Lactose-Carrying Polystyrene" J.Bioactive Compatible Polymers. 7. 337-345 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tobe: "Tissue Reconstruction in Primary Cultured Rat Hepatocytes on Asialoglycoprotein Model Polymer" Artificial Organs. 16. 526-532 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] A.Kobayashi: "Regulation of Differentiation and Proferation of Rat Hepatocytes by Lactose-carrying Polystyrene" Artificial Organs. 16. 564-567 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Steric Control in Ring-Opening Polymerization of 1,6-Anhydro Galactose Derivatives by Neighboring Group Participation" Polymer J.25. 49-57 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Chemical Synthesis of a Comb-shaped Branched Polysaccharide,4-0-α-Mannopyranosyl-(1→6)-α-D-mannopyranan" Carbohydr.Res.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "An Application of Glycotechnology to a Hybrid-type Artificial Liver System" Abstracts of International Biosymposium 92 Nagoya. 231-240 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 小林 一清: "糖鎖高分子合成化学の展開" 海外高分子研究(「レビュー講演」特集号). 38. 108-113 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Biotechnology and Polymers" Plenum, 14 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Polymer Yearbook" Gordon & Breach, 7 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 小林 一清: "「糖質エンジニアリングと製品化技術」" サイエンスフォーラム, 10 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Goto: "Model Study of Hepatocyte Targeting Polymeric Super Molecular Assembly as Drug Carrier" Chem. Lett.1992. 123-126 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Tobe: "Receptor-Mediated Formation of Multilayer Aggregates of Primary Cultured Adult Rat Hepatocyted on Lactose-Substituted Polystyrene" Biochem. Biophys. Res. Commun.184. 225-230 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] A.Kobayashi: "Control of Adhesion and Detachment of Parenchymal Liver Cells Using a Lactose-Carrying Polystyrene as Substrate" J. Biomaterials Sci., Polymer Edn.3. 499-508 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tobe: "Stimulatory Effect of Nonparenchymal Liver Cells on Formation of Multilayer Aggregates of Adult Rat Hepatocytes Cultured on Lactose-Substituted Polystyrene" Commun. Applied Cell Biol.10. 14-21 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Kugumiya: "Investigation of Dynamic Behaviors of Asialoglycoprotein in Receptors of Hepatocytes Using a Latex Probe Whose Surface was Coated with Lactose-Carrying Polystyrene" J. Bioactive Compatible Polymers. 7. 337-345 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] S.Tobe: "Tissue Reconstruction in Primary Cultured Rat Hepatocytes on Asialoglycoprotein Model Polymer" Artificial Organs. 16. 526-532 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] A.Kobayashi: "Regulation of Differentiation and Proliferation of Rat Hepatocytes by Lactose-Carrying Polystyrene" Artificial Organs. 16. 564-567 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Steric Control in Ring-Opening Polymerization of 1,6-Anhydro Galactose Derivatives by Neighboring Group Participation" Polymer J.25. 49-57 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Chemical Synthesis of a Comb-shaped Branched Polysaccharide, 4-0-alpha-Mannopyranosyl-(1(] SY.tautm.[)6)-alpha-D-mannopyranan" Carbohydr. Res.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "An Application of Glycotechnology to a Hybrid-type Artificial Liver System" Abstracts of International Bio Symposium 92 Nagoya. 231-240 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Structure-Controlled Synthesis of Regiospecifically Modified Polysaccharides Starting from Pyrolysis Product of Cellulose" Biotechnology and Polymers. 167-180 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Kobayashi: "Biological and Related Polymers" Polymer Yearbook. 9. 207-213 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M. Goto: "Model Study of Hepatocyte Targeting Polymeric Sugar Molecular Assembly as Drug Carrier" Chem. Lett.1992. 123-126 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S. Tobe: "Receptor-Mediated Formation of Multilayer Aggregates of Primary Cultured Adult Rat Hepatocytes on Lactose-Substituted Polystyrene" Biochem. Biophys. Res. Commun.184. 225-230 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A. Kobayashi: "Controll of Adhesion and Detachment of Parenchymal Liver Cells Using a Lactose-Carrying Polystyrene as Substrate" J. Biomaterials Sci., Polymer Edn.3. 499-508 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S. Tobe: "Stimulatory Effect of Nonparenchymal Liver Cells on Formation of Multilayer Aggregates of Adult Rat Hapato-cytes Cultured on Lactose-Substituted Polystyrene" Commu. Applied Cell Biol.10. 14-21 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T. Kugumiya: "Investigation of Dynamic Behaviors of Asialoglyco-protein Receptors of Hepatocytes Using a Latex Probe Whose Surface Was Coated with Lactose-Carrying Poly-styrene" J. Bioactive Compatible Polymers. 7. 337-345 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] S. Tobe: "Tissue Reconstruction in Primary Cultured Rat Hepato-cytes on Asialoglycoprotein Model Polymer" Artificial Organs. 16. 526-532 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] A. Kobayashi: "Regulation of Differentiation and Proferation of Rat Hepatocytes by Lactose-carrying Polystyrene" Artificial Organs. 16. 564-567 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K. Kobayashi: "Steric Control in Ring-Opening Polymerization of 1,6-Anhydro Galactose Derivatives by Neighboring Group Participation" Polymer J.25. 49-57 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K. Kobayashi: "Chemical Synthesis of a Comb-Shaped Branched Poly-saccharide, 4-0-α-Mannopyranosy1-(1→6)-α-D-mannopyranan" Carbohydr. Res.

    • Related Report
      1992 Annual Research Report
  • [Publications] K. Kobayashi: "An Application of Glycotechnology to a Hybrid-type Artificial Liver System" Abstracts of International BioSymposium 92 Nagoya. 231-240 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小林 一清: "糖鎖高分子合成化学の展開" 海外高分子研究(「レビュー講演」特集号). 38. 108-113 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kobayashi: "Biotechnology and Polymers" Plenum, 14 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] K.Kobayashi: "Polymer Yearbook" Gordon & Breach, 7 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小林 一清: "糖質エンジニアリングと製品化技術" サイエンスフォーラム, 10 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 戸辺 成四郎: "人工マトリックス材料上での肝細胞多層集合体の形成機構と機能性評価" 人工臓器. 20. 150-155 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 戸辺 成四郎: "人工基質材料(PVLA)の設計による肝細胞多層集合体の形成制御ーハイブリッド型人工肝臓の開発に向けてー" バイオインダストリ-. 8. 90-101 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 戸辺 成四郎: "人工臓器高機能化へのチャレンジーハイブリッド型人工肝臓ー" 繊維学会誌(「医用材料の最近の進歩」特集号). 47. 133-141 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小林 一清: "ラクト-ス誘導体を側鎖にもつポリペプチド" 高分子論文集(生体機能材料特集号). 48. 253-256 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "OligosaccharideーSubstituted Polystyrene as a Model System of LigninーCarbohydrate Conjugates" Proceedings of 6th International Symposium on Wood and Pulping Chemistry. 1. 27-31 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小林 一清: "長鎖アルキル基をもつ多糖の合成と機能" 油化学(「糖脂質」小特集号). 40. 379-383 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M. Goto: "Model Study of Hepatocyte Targeting Polymeric Super Molecular Assembly as Drug Carrier" Chem. Lett.1992. 123-126 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "An Application of Glycotechnology to a Hybridーtype Artificial Liver System" Abstracts of International Bio Symposium 92 Nagoya. 231-240 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 小林 一清: "「新しい機能性高分子の分子設計」" シ-エムシ-, 20 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "Polymer Yearbook" Gordon and Breach,Science Publishers,Inc., 6 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "Polymer Yearbook" Gordon and Breach Science Publishers,Inc., 8 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "Biotechnology" Plenum,

    • Related Report
      1991 Annual Research Report
  • [Publications] K. Kobayashi: "Polymer Yearbook" Gordon and Breach Science Publishers,Inc., (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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