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Active Transport and Enzyme Activities in Various Metabolic Disorder of Herbivorous voles

Research Project

Project/Area Number 03660314
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionNippon Veterinary and Animal Science University

Principal Investigator

OKI Yoshio  Nippon Vet.Anim.Sci.Univ., Dept.Vet.Biochem., Professor, 獣医畜産学部, 教授 (30120760)

Co-Investigator(Kenkyū-buntansha) ARAI Toshiro  Nippon Vet.Anim.Sci.Univ., Dept.Vet.Biochem., Lecturer, 獣医畜産学部, 講師 (70184257)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Keywords^<42>Ar-^<42>K generator / active transport / Na^+, K^+-ATPase / glucokinase / ATP-citrate lyase / acetly CoA carboxylase / diabetes / voles / Na^+-K^+ ATPase / NaーK ATPase / ヘキソキナ-ゼ / ATPークエン酸リア-ゼ / アセチルCoAカルボキシラ-ゼ
Research Abstract

1. Active Transport and Na^+, K^+-ATPase in Herbivorous Voles
(a)Active transport : Radioisotope ^<42>K produced by ^<42>Ar-^<42>K generator was orally injected into the voles. After 30 to 60 minutes. the ^<42>K was absorbed mainly from the forestomach and duodenum. The potassium ion was taken into the liver, kidney, heart and adipose tissues, but the uptake activities for ^<42>K were highest in the liver.
(b)Na^+,K^+-ATPase : Na^+, K^+-ATPase activity was investigated in plasma membrane rich fractions from erythrocytes, liver, kidney and skeletal muscle of herbivorous voles. The activity of the ATPase in kidney was higher than those of other tissues. However, the Na^+,K^+-ATPase activities in plasma membranes of kidney in severe diabetic voles were lower than those in normal cases.
2. Hepatic Glycolytic Enzyme and Lipogenic Enzyme Activities in Voles and Mice
(a)Hepatic glycolytic enzyme : Hepatic glycolytic key enzyme, glucokinase in voles were considerablly lower than that in mice. In the monosodium aspartate (MSA)-treated voles, diabetes was induced. In the slight diabetic cases. the glucokinase activities increased about twice, but in the severe diabetic cases. the enzyme activities decreased about half.
(b)Hepatic lipogenic enzymes : Hepatic ATP citrate lyase an acetyl-CoA Carboxylase in voles were considerably lower than those in mice. In the MSA-treated voles and mice, the plasma insulin concentrations increased significantly. The MSA-treated mice showed remarkably obesity and increase of the lipogenic enzyme activities. In the MSA-treated voles, signs of obesity were not observed and hepatic ATP citrate lyase activity increased significantly, but acetyl-CoA carboxylase activity did not increase.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Sasaki,M.,Arai,T.,Shiomi,M.,Ikeda,H.and Oki,Y.: "Changes in plasmainsulin and glucagon conantratuns and hefatic engyme activities in diabetie Vales treated with monosodium asfartate." J.Vet.Med.Soi.53. 541-542 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hasegawa,Y.,Arai,T.,Shiomi,M.,Sasaki,M.and Oki,Y.: "Activities of hefatic ATP citrate lyase and acetyl CoA carbofylase in herbivorous vales and C57BL/6J mice," Exf.Anim.40. 565-567 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki,M.,Arai,T.,Usui,T.and Oki,Y.: "Immunahistochemical,ultrastructural,and hormonal studies on the endocrine hancreas of voles with monosodium asfartate-induced diabetes." Vet.Pathol.28. 497-505 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shibato,T.,Umebori,H.,Sakurai,M.,Arai,T.and Oki,Y.: "Measurement of A ctive Transfart in Bovine T Lymfhoma Cells Using Radioisotahe ^<42>K as a Tracer." Bull.Nippon Vet.Anim.Sci.Univ.40. 1-4 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arai,T.,Hasegawa,Y.and Oki,Y.: "Changes in hefatic lifagenic engyme activeties in voles and mice trealed with monosodium asfartate." Res.Vet.Sci.53. 247-249 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arai,T.,Shinofuji,T.,Ageto,H.,Sugawara,M.and Oki,Y.: "Na^+,K^+-ATPase activity in erythrocytes and certain tissves of bole and mouse" Bull.Nippon Vet.anim.Sci.Univ.41. 25-28 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki,M., Arai,T., Shiomi,M., Ikeda,H., and Oki,Y: "Changes in plasma insulin and glucagon concentrations and hepatic enzyme activities in diabetic voles treated with monosodium aspartate" J.Vet.Med.Sci. 53(3). 541-542 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hasegawa,Y., Arai,T., Shiomi,M., Sasaki,M. and Oki,Y: "Activities of hepatic ATP citrate lyase and acetyl CoA carboxylase in herbivorous voles and C57BL/6J mice" Experimental Animals. 40(49). 565-567 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sasaki,M., Arai,T., Usui,T. and Oki,Y: "Immunohistochemical, ultrastructural, and hormonal studies on the endocrine pancreas of voles (Microtus arvalis) with monosodium aspartate-induced diabetes" Veterinary Pathology. 28(2). 497-505 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arai,T., Sasaki,M., Shiomi,M., Nonoka,T., Ochiai,K and Oki,Y: "Alterations in acetly coenzyme A carboxylase activities in voles and mice treated with monosodium aspartate" J.Vet.Med.Sci. 54(1). 131-135 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arai,T., Hasegawa,Y. and Oki,Y: "Changes in hepatic lipogenic enzyme activities in voles and mice treated with monosodium aspartate" Res.Vet.Sci. 53(2). 247-249 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Arai,T., Shinofuji,T., Ageto,H. Sugawara,M and Oki,Y: "Na^+,K^+-ATPase activity in erythrocytes and certain tissues of vole and mouse" Bull.Nippon Vet.Ani.Sci.Univ. 41. 25-28 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 菅原 盛幸・新井 敏郎・ 大木 与志雄: "炭水化物・VFAおよび非蛋白態窒素の利用に関する草食性ハタネズミの栄養生理的特性" 栄養生理研究会報. 36. 67-87 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arai,T.,Hasegawa,Y. and Oki,Y.: "Changes in hepatic lipogenic enzyme actirities in voles and mice treated with monosodium aspartate." Res.Vet.Sci.53. 247-249 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Arai,T.,Shinoguji,T. Ageto,H., Sugawara,M. and Oki,Y.: "Na^+,K^+-ATPase activity in erythrocytes and certain tissues of vole and mouse." Bull. Nippon Vet.Anim. Sci. Univ.41. 25-28 (1992)

    • Related Report
      1992 Annual Research Report

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Published: 1992-04-01   Modified: 2016-04-21  

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