• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Tumor vascular system -scanning electron microscopic observation of resin casts-

Research Project

Project/Area Number 03660316
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 基礎獣医学
Research InstitutionAzabu University

Principal Investigator

NINOMIYA Hiroyoshi  School of Vet.Mod., Azabu University Professor, 獣医学部, 教授 (00063967)

Co-Investigator(Kenkyū-buntansha) OGIHARA  School of Enviro.Hgg.Assistant Prof., 環境保健学部, 講師 (50154381)
TSUCHIYA Hiroyoshi  School of Enviro.Hgg.Professor, 環境保健学部, 教授 (60063947)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
Keywordsrat fibrosarcoma / resin casts / SEM / vasculature / mammary tumor / degeneration / intra-arterial cushion / vascular wall / 血管 / 樹脂鋳型 / SEM / ラット / 血管の変性 / 血流調節能 / 乳癌 / 血管の変化
Research Abstract

A detailed knowledge of the vascular system of tumors is requisite to a clear understanding of tumor physiology and pathology. Accordingly, in this study, examination was made of the vascular architecture of rat fibrosarcomas induced by 3-methyl choranthrene by scanning electron microscopy of resin casts to observe the three-dimensional vascular pattern of the sarcoma. The results were compared with those of corresponding serial sections of India ink-injected tissue. The major arteries in and around tumors appeared devoid of intra-arterial cushions which regulate blood flow. The arterial lining of resin casts was smooth just at the site where it entered the tumor. This may possibly be indication of degeneration and loss of the smooth muscle layr in the vascular wall. Casts of capillaries were very thin from 4 to 6 mum in diameter and very few sprouts could be seen. Capillaries, frequently present in superficial regions of the tumor, formed a rich irregular fine polygonal network. In fi … More brous tissue in deeper regions of the tumor, this network was coarse. The absence of intra-arterial cushions and degeneration of muscle cells may thus possibly be the reason for the characteristic haemodynamics of tumors.
ABSTRACT.Scanning electron microscopy of resin casts was carried out on the vascular system of hepatoma in Chinese hamster. Casts of capillaries in the hepatoma were thin and fragmentary and formed a fine randomly arranged network in contrast to those in the liver with radial arrangement and central veins in centrilobular regions. Capillaries in the cancer merged into superficial venules corresponding to central veins while those in the border region merged into sinusoids of adjacent liver tissue. The superficial venules connected to tributaries of hepatic veins to drain into the posterior vena cava. Neovascularization did not occur by sprouting and anastomosing to form hair-pin loops of capillaries but by division of pre-existing vessels into smaller vessels, thus increasing the number of capillaries. The hepatic artery feeding the cancer was seemingly intact. There was no indication of arterio-portal shunts in the hepatoma. KEY WORDS : hepatoma.microvasculature.resin cast. Less

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (15 results)

All Other

All Publications (15 results)

  • [Publications] Hiroyoshi Nimomiya,Tomoh INOMATA,Kikumi OGIHARA: "Vascular architecture of 3-methiyl choranthrene-induced rat fibrosarcoma demonstrated by scanning electron microscopy of resin casts." EXP.Anim. 42(4). 593-599 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi Nimomiya,Tomoh INOMATA: "Fine Vasculakure of hepatoma in Chinese hamsters CCricetulus griceus);Scanning electron microscopy of resin casts of blood vessels." J.Vet.Med.Sci.56(6). 1195-1198 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA,Tomoh INOMATA: "Longitudinal sections of seminiferous tubules:A Simple technique for histological studies" EXP.Anim.44(1). 75-77 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi Ninomiya,Tomoh INOMATA,Yoshito WAKAO: "Intrahepatic Portal-Venous changes in dogs with Dirofildliasis:Scanning electron microscopy of resin casts of vasculature" J.Vet.Med.Sci.57(1). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA,Tomoh INOMATA,Takuo SIDA: "Vascular Pattern of a metastatic liver tumor in a dogi A scanning electron microscopic study of resin casts." J.Vet.Med.Sci.57(2). (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA,Tomoh INOMATA and Kikumi OGIHARA: "Vascular architecture of 3-methylchoranthrene- induced rat fibrosarcoma demonstrated by scanning electron microscopy of resin casts." Exp.Anim.42(4). 593-599 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA and Tomoh INOMATA: "Fine vasculature of hepatoma in Chinese hamster (Cricetulus griceus) ; Scanning electron microscopy of resin casts of blood vessels." J.Vet.Med Sci.56(6). 1195-1198 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA and Tomoh INOMATA: "Longitudinal sections of seminiferous tubules ; A simple technique for histological studies." Exp.Anim.44(1). 75-77 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA,Tomoh INOMATA and Yoshito WAKAO: "Intrahepatic portal-venous changes in dogs with Dirofilariasis ; Scanning electron microscopy or resin casts of vasculature." J.Vet.Med Sci. 57(1). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hiroyoshi NINOMIYA,Tomoh INOMATA and Takuo SIDA: "Vascular pattern of a metastatic liver tumor in a dog ; A scanning electron microscopic study of resin casts." J.Vet.Med Sci. 57(2). (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] HiroyoshiNinomiya,TomohInomata,KikumiOgihara: "Vascular architecture of 3-methyl choranthrene-induced rat fibrosarcoma demonstrated by scanning electron microscop of resin casts" Exp.Anim.42(4). 593-599 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Hiroyoshi,Ninomiya,Tomoh,Inomata: "Fine vasculature of hepatoma in Chinese hamster(cricetulus griceus):Scanning electron microscopy of resin casts of blood vessels" J.Vet.Med.Sci.(発表予定).

    • Related Report
      1993 Annual Research Report
  • [Publications] 二宮 博義 他: "Vascular architecture of 3-Methylchoran Threne-induced rat fibrosarcoma demonstrated by scanning electron microscopy of resin casts" 「実験動物」.

    • Related Report
      1992 Annual Research Report
  • [Publications] Ninomiya Hiroyoshi et al.: "Assessment of tumor sensitivity to anticancer aqents basecl on tumor graft vascutauzation on chick chorioallantioc membrane(CAM)" Atternatives to Animal Testing and Experimentation. 1(2). 79-83 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ninomiya Hiroyoshi et al.: "Vaswbr architecture of 3ーmetryl choranthreneーindued rat fibrosarcome demonstreted by Scanning electron mictoscopy of resim casts" The Journal of Veterinery Medical Science.

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi