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EFFECT OF HEAT EXPOSURE ON THE DIURNAL CHANGE OF BODY TEMPERATURE

Research Project

Project/Area Number 03670074
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKANAZAWA UNIVERSITY

Principal Investigator

SAKURADA Sortaro  KANAZAWA UNIV., SCH. MED., INSTRUCTOR, 医学部, 助手 (00215691)

Co-Investigator(Kenkyū-buntansha) TAKAHATA Toshinari  KANAZAWA INST. TECHNOLOGY, ASSOCIATE PROF., 助教授 (90159004)
NAGASAKA Tetsuo  KANAZAWA UNIV., SCH. MED., PROFESSOR, 医学部, 教授 (80023646)
TANABE Minoru  KANAZAWA UNIV., SCH. MED., INSTRUCTOR, 医学部, 助手 (20217110)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,600,000 (Direct Cost: ¥1,600,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsheat acclimation / body temperature / circadian rhythm / heat production / thyroid hormone / energy substrates / feeding / 寒冷馴化 / 熱平衡 / 摂食行動
Research Abstract

After the rats were exposed to heat loaded for about 5 h during the last half of the dark phase for 10 consecutive days, body temperature of the rats significantly decreased during the period corresponding to that of the previous heat exposure time (Shido et al., 1991). The objective of this project was to clarify the mechanism of characteristic fall in body temperature. The heat-exposed (HE) rats were subjected to 33.0゚C for about 5 h in the last half of the dark phase for more than 2 weeks and control (CN) rats were kept at 24゚C. After the completion of the schedule, the levels of hypothalamic temperature (Thy), heat loss, heat production, feeding activity (FA) and body movement were significantly lower in the HE than in the CN during the period when the HE rats had been exposed to heat. Even in fasting condition from 6 h before the start of the experiment, significant difference in Thy still existed. These results suggest that the characteristic fall in Thy is partly mediated by the decrease in FA, however, there are also another contributors. To investigate the contribution of plasma levels of thyroid hormones and energy substrates, plasma levels of triiodothyronine (T3), free T3 (FT3), thyroxin (T4), free T4 (FT4), triglyceride, non esterified fatty acid, total protein and glucose were measured at 3 h interval between 0000 and 1800 h (dark phase, 0300-1500 h). Plasma levels of T3 and FT3 during the previous heat exposure period were significantly higher in the HE than in the CN. Similar differences were observed in T4 and FT4 levels. Plasma levels of energy substrates did not differ between 2 groups. These results suggest minimum contributions of thyroid hormones to the characteristic falls in Thy in the HE rats. Farther studies are required to clarify the mechanisms of the characteristic fall in Thy.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] SHIDO,Osamu: "Shifts in the hypothalamic temperature of rats acclimated to direct internal heat load with different schedules." Journal of Thermal Biology. 16. 267-271 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHIDO,Osamu: "Effect of heat acclimation on diurnal changes in body temperature and locomotor activity in rats." Journal of Physiology(London). 433. 59-71 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHIDO,Osamu: "Temperature regulation during acute heat loads in rats after short-term heat exposure." Journal of Applied Physiology. 71. 2107-2113 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHIDO,Osamu: "Modification of nycthermal changes in body temperature by repeated cold exposure in rats."

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHIDO,Osamu: "Increase in plasma thyroid hormone levels during the previous heat exposure time in rats acclimated to heat loaded for hours at a fixed time daily."

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SAKURADA,Sohtaro: "Shivering and nonshivering thermogenic responses of rats subjected to different patterns of heat acclimation." Canadian Journal of Physiology and Pharmacology.(1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shido, O., Yoneda, Y. and Nagasaka, T.: "Shifts in the hypothalamic temperature of rats acclimated to direct internal heat load with different schedules." J. therm. Biol.16. 267-271 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shido, O., Sakurada, S. and Nagasaka, T.: "Effect of heat acclimation on diurnal changes in body temperature and locomotor activities in rats." J. Physiol. (London). 433. 59-71 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shido, O., Sakurada, S., Tanabe, M. and Nagasaka, T.: "Temperature regulation during acute heat loads in rats after short-term heat exposure." J. Appl. Physiol.71. 2107-2113 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shido, O., Sakurada, S., Fujikake, K. and Nagasaka, T.: "Modification of nycthemeral changes in body temperature by repeated cold exposure in rats."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shido, O., Sakurada, S., Hashimoto, T., Fujikake, K. and Nagasaka, T.: "Increase in plasma thyroid hormone levels during the previous heat exposure time in rats acclimated to heat for hours at a fixed time daily."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Sakurada, S. and Shido, O.: "Shivering and nonshivering thermogenic responses of rats subjected to different patterns of heat acclimation." Canadian P. Physiol. Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] SHIDO,Osamu: "Shifts in the hypothalamic temperature of rats acclimated to direct internal heat load with different schedules." Journal of Thermal Biology. 16. 267-271 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIDO,Osamu: "Effect of heat acclimation on diurnal changes in body temperature and locomotor activity in rats." Journal of Physiology(London). 433. 59-71 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIDO,Osamu: "Temperature regulation during acute heat loads in rats after short-term heat exposure." Journal of Applied Physiology. 71. 2107-2113 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIDO,Osamu: "Modification of nycthermal changes in body temperature by repeated cold exposure in rats." in preparation.

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIDO,Osamu: "Increase in plasma thyroid hormone levels during the previous heat exposure time in rats acclimated to heat loaded for hours at a fixed time daily." in preparation.

    • Related Report
      1992 Annual Research Report
  • [Publications] SAKURADA,Sohtaro: "Shivering and nonshivering thermogenic responses of rats subjected to different patterns of heat acclimation." Canadian Journal of Physiology and Pharmacology,. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] SHIDO,Osamu: "Changes in body temperature of rats acclimated to heat with different acclimation schedules." Journal of Applied Physiology. 67. 2154-2157 (1989)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIDO.Osamu: "Thermoregulatory responses to acute body heating in rats acclimated to continuous heat exposure." Journal of Applied Physiology. 68. 59-65 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIDO,Osamu: "Heat loss responses in rats acclimated to heat loaded intermittently." Journal of Applied Physiology. 68. 66-70 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIDO,Osamu: "Effect of heat acclimation on diurnal changes in body temperature and locomotor actibity in rats." Journal of Physiology(London). 433. 59-71 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SHIDO,Osamu: "Shifts in the hypothalamic temperature of rats acclimated to direct internal heat load with different schedules." Journal of Thermal Biology. 16. 267-271 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] SAKURADA,Sohtaro: "Mechanism of vasoconstriction in the rat's tail when warmed locally." Journal of Applied Physiology. 71. 1758-1763 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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