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Baroreflex control of arterial pressure under simulated micro gravity in dogs

Research Project

Project/Area Number 03670085
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

MIKI Kenju  Univ.Occup.and Environ.Health Dept.of Physiol.Assistant professor, 医学部, 講師 (80165985)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsArterial pressure / Baroreflex / Carotid sinus baroreceptors / Micro gravity / Sympathetic nerve acitivity / 頚動脈洞 / 頸動脈洞 / 微小重力 / 圧反射 / 交感神経活動
Research Abstract

The purpose of the present study was to evaluate an acute modification of baroreflex control of RSNA in conscious dogs. Simultaneous recordings of carotid sinus nerve activity (CSNA) and RSNA were made during raising and lowering systemic arterial pressure by administrations of phenylephrine (150 ug iv.) and nitroprusside (300 ug iv.), respectively, in 9 conscious dogs. Relationship between mean carotid arterial pressure (Pmca) and RSNA was analyzed by fitting obtained values to a sigmoidal equation ; Pmca=A1/(1+exp(A2(X-A3))+A4 ; where X is RSNA ; A1, a range of Pmca ; A2, a gain of Pmca-RSNA response ; A3, a midpoint pressure (Pmca at the maximum gain) ; A4, a minimum value of Pmca. WI induced an acute modification of carotid sinus baroreflex control of RSNA, because A2 increased by 84%, A3 decreased by 17 mmHg, whereas A1 and A4 were constant. These data indicate that WI results in a leftward shift of the Pmca-RSNA relationship. The Pmca-CSNA relationship was analyzed similarly to study nature of carotid sinus baroreceptors during WI. The Pmca-CSNA curve did not change during control, WI and recovery periods, indicating that the modification of Pmca-RSNA relationship was not attributed to changes in a nature of carotid sinus baroreceptors. It is concluded that WI induces an acute modification of baroreflex control of RSNA at site of the supra-carotid baroreceptors.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] MIKI,K.,HAYASHIDA,and K.SHIRAKI.: "Baroreflex control of renal sympatheitc nerve activity (RSNA)is modified acutely during water immersion (WI)in conscious dogs." Am.J.Physiol.264. R369-R375 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] MIKI,K.,HAYASHIDA,and K.SHIRAKI.: "Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension." The FASEB Journal. 6. A1176 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 三木 健寿,林田 嘉朗,白木 啓三: "圧受容器反射の急性リッセテイングは圧受容器の適応現象で説明されるか?" 日本生理学雑誌. 54. 23 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Miki, Y.Hayashida, and K.K.Shiraki: "Baroreflex control of renal sympathetic nerve activity (RSNA) is modified acutely during water immersion (WI) in conscious dogs" Am.J.Physiol. 264. R369-R375 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Miki, Y.Hayashida, and K.K.Shiraki: "Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension" The FASEB Journal. volume 6 Number 4. A1176 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Miki,K.,Y.Hayashida,and K.Shiraki.: "Baroreflex control of renal sympathetic nerve activity (RSNA) is modified acutely during water immersion (WI) in conscious dogs." Am.J.Physiol.264. R369-R375 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miki,K.,Y.Hayashida,and K.Shiraki.: "Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension." The FASEB Journal. 6. A1176- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 三木 健寿、林田 嘉朗、白木 啓三: "圧受容器反射の急性リッセテイングは圧受容器の適応現象で説明されるか?" 日本生理学雑誌. 54. 23- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Miki.,Hayashida,Y.and Shiraki K.: "Baroreflex control renal sympathetic nerve activity (RSNA)reset acutely at the supra-carotid site during water immersion (WI)in conscious dogs." The Japanese Journal of Physiology. 41. S85 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 三木 健寿,林田 嘉郎,白木 啓三: "圧受容器反射の急性リセッテイングは圧受容器の適応現象で説明されるか?" 第42回西日本生理学会予稿集、福岡大学. (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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