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Analysis of immunoregulatory anti-idiotypic antibodies during human schistosomiasis japonica.

Research Project

Project/Area Number 03670191
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 寄生虫学(含医用動物学)
Research InstitutionOkayama University

Principal Investigator

OHTA Nobuo  Associate Professor, Dept. of Parasitology Okayama University Medical School, 医学部, 助教授 (10143611)

Co-Investigator(Kenkyū-buntansha) ONO Toshiro  Res. Associate, Dept. of Parasitology Okayama University Medical School, 医学部, 助手 (50185641)
AJI Toshiki  Lecturer, Depr. of Parasitology Okayama University Medical School, 医学部, 講師 (10032905)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsSchistosoma japonicum / Soluble egg antigen / T cells / Anti-idiotypic antibody / Cytokines / ELISA / イディオタイプ / SEA
Research Abstract

We analyzed immunological roles of anti-idiotypic T cell responses during human schistosomiasis japonica. Sera of chronic patients induced significant proliferation of T cells from individuals of previous infection. The responding cells were positive for CD3 and CD4, but were CD8-negative. Those T cells produced IFN- in response to the infected sera, whereas no detectable IL-4 and IL-5 were produced. This suggested that Th1 cells were reactive to the sera, and those could be antagonistic to Th2 cells which were tightly involved in granulomatous hypersensitivity to schistosome eggs. The serum factor(s) was observed in IgG fraction, but was different from an anti-schistosome egg antibody. In some cases chronic sera induced responses of established T cell lines specific for Schistosoma japonicum egg antigen, and it was thus highly likely that the serum factor was anti-idiotypic IgG recognizing antibodies to anti-S. japonicum egg antigen.
Such anti-idiotypic antibodies were observed only in fresh patients, however, no activity was observed in individuals who had been treated more than 7 years before. When we compared the reactivities of "fresh" and "old" sera to the egg antigen fractionated by HPLC, a 400kD fraction(s) was recognized only by "fresh" patient sera. The difference in specificity of anti-schistosome IgG seemed to have influence on anti-idiotypic antibody responses in various infection phases during human infection of S. japonicum.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] OHTA N.et al.: "Regulation of the human T cell response to Schistosoma japonicum egg antigen by concomitant cellular and humoral mechanisms in vitro." Parasitology Research. 77. 54-58 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 太田 伸生他: "日本住血吸虫症の免疫病理学的研究:宿主T細胞の応答を通じた病因解析および寄生虫による宿主の発がん機構について" 岡山医学会雑誌. 103. 133-143 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 太田 伸生: "HLAと感染" Medical Immunology. 21. 207-214 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Min W.et al.: "Analysis of soluble egg antigen of Schistosoma japonicum Comparison of seroreactivities among schistosomiasis patients of different infection phases." Japanese Journal of Parasitology. 41. 401-407 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 太田 伸生: "微生物の抗原変異と病原性:シストゾーマ" 臨床と微生物. 19. 503-509 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta N. et al.: "Regulation of the human T cell response to Schistosoma japonicum egg antigen by concomitant cellular and humoral mechanisms in vitro." Parasitol Res. 77. 54-58 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta N. et al.: "Immunopathological analyses of schistosomiasis japonica : The role of T cells in the pathogenesis and carcinogenesis associated with parasitic infection. (Text in Japanese)" Okayama Igakkai Zasshi. 103. 133-143 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta N.: "HLA and infectious diseases." Medical Immunol. 21. 207-214 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Min W. et al.: "Analysis of soluble egg antigen of Schistosoma japonicum : Comparison of sero-reactivities among schistosomiasis patients of different infection phases." Jpn J Parasitol. 41. 401-407 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ohta N.: "Antigen variation and pathogenesis : Schistosoma. (Text in Japanese)" Clinical Microbiol. 19. 503-509 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Min W. et al.: "Analysis of soluble egg antigen of Schistosoma japonicum: Comparison of seroreactivities among schistosomiasis patients of different infection phases." Japanese Journal of Parasitology. 41. 401-407 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 太田 伸生: "微生物の抗原変異と病原性:シストゾーマ" 臨床と微生物. 19. 503-509 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ohta N,Song,Ishi A,Hosaka Y & Shimono K.: "Anlysis of parasite sntigens inducing suppressor T cell response during human chronic schistosomiasis japonica."

    • Related Report
      1991 Annual Research Report
  • [Publications] Min w,Aji T,Ono T & Ohta N.: "A syudy on antigen determinants between specific and nonspecific IgG reaction among fascioliasis,paragonimiasis and schistsomiasis in humans."

    • Related Report
      1991 Annual Research Report
  • [Publications] 太田 伸生: "HLAと感染" Medical Immunology. 21. 207-214 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 太田 伸生: "微生物の抗原変異と病原性、シストゾ-マ" 臨床と微生物. 19. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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