| Project/Area Number |
03670277
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
HIGASHI Toshiaki University of Occupational and Environmental Health, Japan, Department of Work Systems and Health, Professor, 産業生態科学研究所・作業病態学, 教授 (10119000)
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| Co-Investigator(Kenkyū-buntansha) |
HYAKUDO Toshihisa University of Occupational and Environmental Health, Japan, Department of Enviro, 産業生態科学研究所・労働衛生工学, 助手 (20228753)
FUJINO Akihiro University of Occupational and Environmental Health, Japan, Department of Health, 産業生態科学研究所・産業保健管理学, 助手 (00209074)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | ASBESTOS / EPIDEMIOLOGY / CHEST ROENTOGENOGRAPH / PNEUMOCONIOTIC / PLEURAL THICKENING / PLEURAL PLAQUE / EXPOSURE-RESPONSE RELATIONSHIP / 曝露量ー反応関係 |
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| Research Abstract |
A cross sectional study on chest roentogenographs of asbestos containing products manufacturing workers in order to evaluate the effect of relatively low exposure to asbestos. Among 1496 subjects, 1077 male (age 42 + 8.7) and 419 females (age 40 + 9.4), 92 cases (6.1%) had pnemoconiotic changes (PR1*) and 87 cases (5.8%) had pleural changes. The range of asbestos exposure was from 6 months to 29 years. The prevalence of pleural thickening (5.9%) was higher in asbestos exposed workers in comparison with referent group (3.4%) who had been engaged in a refractory plant with dust exposure other than mineral fibers, and the rate of that in workers
(10.8%) With over 15 years asbestos exposure was significantly (p<0.05) higher than that of the referent group (5.4%). Twelve cases of pleural plaques (0.8%) were observed in asbestos exposed group and the rate was slightly higher than the rates (0.03-0.6%) in public population reported by other researchers using similar diagnostic criteria. Age and cummulative asbestos exposure index (estimated environmental concentration in f/ml x exposure duration in years) were suggested to contribute the prevalence of pleural changes, analyzed by using a logistic regression model.
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