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Hepatitis C virus and cirrhosis and hapatocellular carcinoma.

Research Project

Project/Area Number 03670286
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionNagoya City University Medical School (1992-1993)
佐賀医科大学 (1991)

Principal Investigator

TOKUDOME Shinkan  Nagoya City University Medical School, Department of Public Health, Professor, 医学部, 教授 (00037441)

Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1993: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
KeywordsHepatitis C virus / Cirrhosis and hepatocellular carcinoma / Epidemiologic study / C型肝炎ウィルス / 感染ルート / 環境要因 / 疫学 / 追跡研究
Research Abstract

(1) Life style and environmental factors related to hepatitis C virus (HCV) infection are now investigated.
(2) Life style and enviromental factors associated with the onset of hepatocellular carcinoma (HCC) are now studied.
(3) Follow-up study of 3,237 asymptomatic HCV carriers was carried out. Average follow-up period was 2.7 years. The observed number of deaths was tabulated and compared with the expected numbers, which was calculated using the death rates of the general population of Japan. The ratio of observed/expected number of deaths was computed. The O/E ratio for all causes was decreased, which was explained by the selection bias or healthy donor effect, short observation period, and the expected numbers based on the general population instead of HCV-free population. The O/E ratio of hepatocellular carcinomawas elevated in males as well as in females. The risk of HCC among subjects with more than 36 of GPT was higher than that of those with 35 or less.
(4) Accurate analytic methods of HCV genotype are now developed for epidemiologic and clinical studies.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 徳留 信寛ほか: "無症候性HCVキャリアのフォローアップ" 日本衛生学雑誌. 50. 527- (1995)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ohno,T.,Tokudome,S.et al.: "Molecular evolutionary classification of hepatitis C virus isolated from Egyptian and Yemeni patients" J.Med.Virol.((submitted))

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tokudome, S.and Ohno, T.: "Follow-up study of asymptomatic HCV carriers." Jpn.J.Hygiene. 50. 527 (1995)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ohno, T., Tokudome, S.et al.: "Molecular evolutionary classification of hepatitis C virus isolated from Egyptian and Yemeni patients." J.Med.Virol.(submitted).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yonezawa,S.,Tokudome,S et al.: "Covalent coupling of a steroid to microwell plates for use in a competitive enzyme-linked immunosorbont assay." J.Immunol.Methods. 166. 55-61 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tokudome,S.et al.: "Smoking and adult T-cell leukemia/lymphoma." Eur.J.Cancer Prev.2. 84-85 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Tokunaga,O.,Tokudome,S.et al.: "Primary T-cell lymphoma of the gastrointestinal tract associated with human T-cell lymphotropic virus type I.An analysis using in situ hybridization and polymerase chain reaction." Cancer. 71. 708-716 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 徳留 信寛: "成人T細胞白血病・リンパ腫とHTLV-1関連脊髄症に関する疫学的研究" 癌の臨床. 38. 337-342 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maeda,Y.,Tokudome,S.et al.: "Time trends of HBsAg prevalence among blood donors in Fukuoka,Japan." Eur.J.Epidemiol.8. 88-92 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kamihira,S.,Tokudome,S.et al.: "Risk of adult T-cell leukemia developing in individuals with HTLV-I infection." Leukemia Lymphoma. 6. 437-439 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamaguchi,K.,Tokudome,S.et al.: "Declining trends of HTLV-I prevalence among blood donors in Kumamoto,Japan." J.AIDS. 5. 533-534 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Oguma,S.,Tokudome,S.et al.: "Accelerated declining tendency of human T-cell leukemia virus type I carrier rates among younger blood donors in Kumamoto,Japan." Cancer Res.52. 2620-2623 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tokudome,S.et al.: "HAM/TSP attributable to blood transfusion." J.Neurol.Neurosurg.Psychiat.55. 738- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Asakura,T.et al.: "Concomitant carriage of hepatitis B virus and human Tーlymphotropic virus type I among blood donors in Kitakyushu,Japan." J.Inf.23. 33-37 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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