| Project/Area Number |
03670331
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Sapporo Medical College |
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Principal Investigator |
IAMI Kohzoh Sapporo Med. College, Dept. of Int. Med., Assoc. Prof., 医学部, 助教授 (60117603)
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| Co-Investigator(Kenkyū-buntansha) |
YACHI Akira Sapporo Med. College, Dept. of Int. Med., Prof., 医学部, 教授 (50045324)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Amyloidosis / Amyloid-related protein gene / Alzheimer's disease / AA protein / New amyloid-related protein / アミロイド-シス / アミロイド蛋白 / モノクロ-ナル抗体 / AM34抗原遺伝子 |
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| Research Abstract |
Amyloidosis is a metabolic disease characterized by the deposition of amyloids in various organs. Several of the proteins involved in the deposition process have been identified recently. We found evidence of a novel protein in amyloid deposits in both secondary amyloidosis and Alzheimer's disease (AD) in experiments with monoclonal antibody (MoAb) AM34 in 1988. We recently succeeded in sequencing the AM34 molecule ; subsequently, a library search showed that this molecule has extensive homology with human complement factor H (Factor H). The exact role of this factor H in the AD brain remains to be defined. It is also of note, that this molecule is present in amyloid deposits of both secondary amyloidosis and Alzheimer's senile plaque, suggesting a crucial role of this particular molecule in the formation of amyloid deposits.
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