サイトカインによるIgE抑御機構にもとずくI型アレルギー疾患治療への試み
| Project/Area Number |
03670336
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Juntendo University School of Medicine |
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Principal Investigator |
HIRANO Takao Juntendo University Assistant Professor, 医学部, 講師 (10165186)
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| Co-Investigator(Kenkyū-buntansha) |
HIROSE Shunichi Juntendo University, Professor, 医学部, 教授 (70010147)
OKUMURA Ko Juntendo University, Professor, 医学部, 教授 (50009700)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | IgE / IL-2 / IL-4 / M.T.T / IgE supprossion / Gold therapy / RA / Immunotherapy / MTT / ILー4 / ILー2 |
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| Research Abstract |
(1) We demonstrated that IgE production induced IL-4 was suppressed by IL-2 invitro and invivo.
(2) We established sensitive methods to detect cytokine such as IL-2, IL-4, IL-6 by M.T.T.
(3) We showed a Gold thiomalate was a strong IL-2 inducer by human lymphocyte culture system in vitro.
(4) We found that IgE production of a patient with Rheumatoid Arthritis was decreased by Gold therapy, so that immunotherapy using IL-2, IL-2 inducer (Gold) was helpful for type I of allergic disease.
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Report
(3 results)
Research Products
(11 results)
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[Publications] Miyajima,H., Hirano,T., Hirose,S., Karasuyama,H., Okumura,K. and Ovary,Z.: "Suppression by IL-2 of IgE production by B cells stimulated by IL-4." J. Immunology. 146. 457-462 (1991)
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「研究成果報告書概要(欧文)」より
Related Report
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[Publications] Usui,M., Hirano,T., Miyajima,H., Ando,s., Kurimoto,M., Yamagi,C., Matsuhashi,T., Ovary,Z. and Okumura,K.: "Construction of a monoclonal antibody to Igh-7." Immunogenetics. 37. 301-304 (1993)
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[Publications] Takai,S., Tateno,M., Hirano,T., Kondo,N., Hirose,S. and Yoshiki,T.: "Increased IgE level as a marker of Host versus Graft disease : inhibition of this HVGD with a monoclonal antibody to IL-4." Cellular Immunology. (1993)
Description
「研究成果報告書概要(欧文)」より
Related Report
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