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Mechanism of primary biliary cirrhosis and free radicals

Research Project

Project/Area Number 03670342
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionAsahikawa Medica College

Principal Investigator

SEKIYA Chihiro  Asahikawa Med.Col., Internal Medicine III, Lecturer, 医学部, 講師 (30109384)

Co-Investigator(Kenkyū-buntansha) TANIGUCHI Naoyuki  Osaska University Med. School, Biochemistry, Professor, 医学部, 教授 (90002188)
ONO Minoru  Asahikawa Med.Col., Internal Medicine III, Assistant Professor, 医学部, 助手 (60185650)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsprimary biliary cirrhosis / free radicals / manganese-superoxide dismutase / Mn‐SOD / Mnーsuperoxide dismutase / 活性酸素 / フリ-ラジカル / サイトカイン
Research Abstract

Serum manganese-superoxide dismutase (Mn-SOD) was determined in patients with various liver diseases with an enzyme-linked immunosorbent assay using a specific monoclonal antibody.
The serum Mn-SOD level in patients with primary biliary cirrhosis (PBC) was significantly increased compared with those of other liver diseases, including chronic viral hepatitis, liver cirrhosis, autoimmune hepatitis, obstructive jaundice, fatty liver and idiopathic portal hypertension. Administration of ursodeoxycholic acid caused the significant decrease of serum Mn-SOD level in PBC patients. Immunostaining of a liver biopsy specimen from the patients with PBC revealed increased expression of the enzyme protein in damaged hepatocytes and degenerated epithelial cells of interlobular bile ducts.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Ono M: "Elevated level of serum Mn-superoxide dismutasse in patients with primarybiliary cirrhosis:Possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大平 基之: "原発性胆汁性肝硬変症とmanganese-superoxide dismutase" 日本消化器病学会雑誌. 89. 1474 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大平 基之: "PBC患者における血清Mn-SOD:UDCA投与による変動" 肝臓. 33. 811 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono M: "Induction of Mn-superoxide dismutase by tumor necrosis factor,interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commun. 182. 1100-1107 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 大平 基之: "肝臓病up date肝炎のA型からG型まで" 中外医学社, 6 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] ONO M.: "Elevated level of serum Mn-supweoxide dismutase in patients with primary biliary cirrhosis : Possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] OHHIRA M.: "Primary biliary cirrhosis and manganese-superoxide dismutase." Jpn J Gastroenterol. 89. 1474 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] OHHIRA M.: "Serum Mn-SOD levels in primary biliary cirrhosis : Effects of UDCA administration." Acta Hepatol Jpn. 33. 811 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] ONO M.: "Induction of Mn-superoxide dismutase by tumor necrosis factor, interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commum. 182. 1100-1107 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ono M: "Elevated level of serum Mn-superoxide dismutasse in patients with primary biliary cirrhosis:Possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大平基之: "原発性胆汁性肝硬変症とmanganese-superoxide dismutase" 日本消化器病学会雑誌. 89. 1474 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大平基之: "PBC患者における血清Mn-SOD:UDCA投与による変動" 肝臓. 33. 811 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ono M: "Induction of Mn-superoxide dismutase by tumor necrosis factor,interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commun. 182. 1100-1107 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] 大平基之: "肝臓病up date肝炎のA型からG型まで" 中外医学社, 6 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ono M: "Elevated level of serum Mn-superoxide dismutasse in patients with primary biliary clrrhosis : possible involvement of free radicals in the pathogenesis in primary biliary cirrhosis." J Lab Clin Med. 118. 476-483 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大平 基之: "原発性胆汁性肝硬変症とmanganese-superoxide dismutase" 日本消化器病学会雑誌. 89. 1474- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大平 基之: "PBC患者における血清Mn-SOD:UDCA投与による変動" 肝臓. 33. 811- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ono M: "Induction of Mn-superoxide dismutase by tumor necrosis factor,interleukin-1 and interleukin-6 in human hepatoma cells." Biochem Biophys Res Commun. 182. 1100-1107 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Ono M,et al.: "Induction of Mnーsuperoxide dismutase by tumor necrpsis factpr,interleukinー1 and interleukinー6 in human hepatoma cells.Biochem Biophy Res Commun 182;1100ー1107,1992." Biochem Biophys Res Commun. 182. 1100-1107 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Ono M,et al.: "Elevated level of serum Mnーsuperoxide dismutase in patients with primary biliary cirrhosisーpossible involvement of free radicals in the pathogenesis of primary biliary cirrhosis" J Lab Clin Med. 118. 476-483 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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