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IMMUNOMODULATORYEFFECTS OF URSODEOZXYCHOLIC ACID ON IMMUNE RESPONSES

Research Project

Project/Area Number 03670373
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNARA MEDICAL UNIVERSITY

Principal Investigator

TSUJII Tadasu  NARA MEDICAL UNIV. DEPT. OF 3RD INT. MED. PROFESSOR, 医学部, 教授 (30075064)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Masahide  NARA MEDICAL UNIV. DEPT. OF 3RD INT. MED. ASSISTANT PROFESSOR, 医学部, 助手 (50230701)
KUBO Ryouichi  NARA MEDICAL UNIV. DEPT. OF 3RD INT. MED. ASSISTANT PROFESSOR, 医学部, 助手 (20183311)
ISHIZAKA Shigeaki  NARA MEDICAL UNIV. DEPT. OF 3RD INT. MED. ASSOCIATE PROFESSOR, 医学部, 講師 (90159715)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥900,000 (Direct Cost: ¥900,000)
KeywordsUrsodexycholic acid / Immunoglobulin / Cytokine / Interleukin 2 / Interleukin 4 / Gamma interferon / Antigen presentation / ウルソデオキシコ-ル酸 / 免疫グロブリン産生 / サイトカイン産生 / PBC
Research Abstract

We investigated the direct effects of ursodeoxycholic acid(UDCA) on immunoglobulin(Ig) and cytokine production in vitro. UDCA suppressed the production of IgM, IgG and IgA induced by Staphylococcus aureus Cowan A in peripheral blood mononeclear cells(PBMCs) derived from healthy subjects and patients with PBC. The productions of IL-2, IL-4 and rIFN in PBMCs were also suppressed by UDCA. Then we investigated UDCA effects on antigen presentation using mouse T hybridoma cells as helper T cells(Th) and mouse B lymphoma cells as antigen presenting cells(APCs), both of which possessed defined antigen specificities. UDCA suppressed IL-2 production and cytotoxic function of Th. Antigen pulsed APCs were able to activate Th to produce IL-2, suggesting that UDCA might not affect the function of APCs. We conceive that UDCA may work as an immunomodulator in vivo, especially in liver where the concentration of UDCA could reach a level high enough to provoke immunonological effects.

Report

(2 results)
  • 1992 Final Research Report Summary
  • 1991 Annual Research Report

Research Products

(7 results)

All Other

All Publications (7 results)

  • [Publications] 吉川 正英.他: "ウルソデオキシコール酸の免疫系に及ぼす影響" 肝臓. 32. 125-126 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YOSHIKAWA M,et al: "IMMUNOMODULATORY EFFECTS OF URSODEOXYCHOLIC ACID ON IMMUNE RESPONSES" Hepatology. 16. 358-364 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YOSHIKAWA M, et al.: "Immunomodulatory effects of ursodeoxycholic acid on immune responses." Hepatology. 16. 358-364 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YOSHIKAWA M, et al.: "Effects of ursodeoxycholic acid on immune system." Acta Hepatology Japonica (in Japanese). 32. 125-126 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉川 正英、他: "ウルソデオキシコ-ル酸の免疫系に及ぼす影響" 肝臓. 32. 125-126 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉川 正英、他: "ウルソデオキシコ-ル酸の免疫グロブリン産生抑制効果ーPBC治療との関連においてー" 第6回肝臓病研究会論文集. 12-16 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Masahide Yoshikawa,et al: "Immunomodulatory effects of ursodeoxycholic acid on immune responses"

    • Related Report
      1991 Annual Research Report

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Published: 1991-03-31   Modified: 2016-04-21  

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