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Biochemical mechanism for the progression from hypertrophic cardiomyopathy into dilated cardiomyopathy-like features

Research Project

Project/Area Number 03670456
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionEhime University

Principal Investigator

HAMADA Mareomi  Ehime University, The 2nd Department of Internal Medicine, Associate Professor, 医学部, 助教授 (30127906)

Co-Investigator(Kenkyū-buntansha) SUMIMOTO Takumi  Ehime University The 2nd Department of Internal Medicine, Assisntant Professor, 医学部, 助手 (10187809)
SHIGEMATSU Yuji  Ehime University The 2nd Department of Internal Medicine, Assistant Professor, 医学部, 助手 (90206087)
松岡 宏  愛媛大学, 医学部・附属病院, 助手 (10238991)
岩田 猛  愛媛大学, 医学部, 助手 (10193749)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsHypertrophic Cardiomyopathy / Dilated Cardiomyopathy-like Feature / Creatinine Kinase / Lactate Dehydrogenase / Electrocardiography / Echocardiography / Thallium Myocardial Scintigraphy / Nyocardial Ischemia / 核磁気共鳴画像 / 冠状動脈 / 冠動脈-左室腔シャント / 乳酵脱水素酵素 / アイソエンザイム / タリウム‐201心筋シンチグラム / クレアチンキナ-ゼ / クレアチンキナ-ゼアイソフォ-ム / 心エコ-図
Research Abstract

In order to elucidate the mechanism for the change from typical hypertrophic cardiomyopathy to dilated cardiomyopathy-like features, biochemical parameters such as serum creatine kinase (CK), lactate dehydrogenase (LDH), their isoenzymes (CK-MB, LDH1) and CK-MM isoforms (MMa, MMb and MMc) were serially measured in 58 patients with hypertrophic cardiomyopathy. In addition, total 12-lead QRS amplitude on electrocardiogram, left ventricular end-diastolic dimension and thallium-201 myocardial scintigraphy were evaluated using the initial and the latest recordings. Mean follow-up period was 63.2 (〕SY.+-.〔) 26.2 months.
A significantly high value of CK-MB ranging 2.5% and 14%, LDH1 more than 30% and MMa/MMc ratio more than 0.5, which are higher than maximal values in normal controls and hypertensive patients, was observed in 70%, 62% and 68%, respectively. High values of CK-MB and LDH1 have persisted. Total QRS amplitude significantly decreased from 32.6 (〕SY.+-.〔) 10.8 to 25.2 (〕SY.+-.〔) 7.6mV, and left ventricular end-diastolic dimension significantly increased from 44.3 (〕SY.+-.〔) 7.6 to 50.6 (〕SY.+-.〔) 6.8mm. Thallium-201 uptake had been persistently and gradually decreased in almost all the patients with hypertrophic cardiomyopathy.
Our study indicates that many patients with hypertrophic cardiomyopathy may be associated with chronic cellular damage, and the progression from hypertrophic cardiomyopathy to dilated cardiomyopathy-like features is the natural course of hypertrophic cardiomyopathy.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Mareomi Hamada: "Serum creatine kinase MM isoforms in hypertrophic cardiomyopathy" Clinical Science. 81. 723-726 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasushi Fujiwara: "Scintigraphic.assessment of cardiac adrenergic innervation in patients with essential hypertension" Journal of Cardiovascular Pharmacology. 17(suppl2). s148-s150 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasushi Fujiwara: "Different myocardial distribution patterns between iodine-123 metaiodobenzylguanidine and thallium-201 in hypertrophic cardiomyopathy" American Journal of Noninvasive Cardiology. 6. 177-183 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Ohtani: "Morphological characteristics of hypertrophic cardiomyopathy estimated by left ventriculography" Japanese Circulation Journal. 57. 418-425 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 川上秀生: "Gd-DTPA造影MRIによる心筋障害の把握" 映像情報MEDICAL. 24. 69-74 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 濱田希臣: "肥大型心筋症から拡張型心筋症類似病態へ" 日本内科学会雑誌. 82. 26-31 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Mareomi Hamada: "New Aspect of Treatment of Failing Heart" Yasuda H & Kawaguchi H(Eds.)(Springer-Verlag), 3 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 濱田希臣: "《循環器NOW》シリーズ,No.6 心筋症・心筋炎" 和泉徹編集(南江堂) (印刷中), (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takashi Ohtani: "Morphological characteristics of hypertrophic cardiomyopathy estimated by left ventriculography" Japanese Circulation Journal. 54. 418-425 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 川上秀生: "Gd-DTPA造影MRIによる心筋障害の把握" 映像情報MEDICAL. 24. 69-74 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 濱田希臣: "肥大型心筋症から拡張型心筋症類似病態へ" 日本内科学会雑誌. 82. 26-31 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 濱田希臣 和泉徹 編集: "《循環器NOW》シリーズ,No.6心筋症・心筋炎" (印刷中)南江堂, (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Mareomi Hamada,et al.: "Serum creatine kinase MM isoforms in hypertrophic cardiomyopathy" Clinical Science. 81. 723-726 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mareomi Hamada,et al.: "Persistent elevation of serum creatine phosphokinase,lactic dehydrogenase and their isoenzymes in patients with hypertrophic cardiomyopathy" Lancet.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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