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Studies for gene on agammaglobulinemia B cells

Research Project

Project/Area Number 03670488
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionGifu University

Principal Investigator

KONDO Naomi  Gifu University School of Medicine, Associate professor, 医学部, 助教授 (50124714)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsCommon variable immunodeficiency / Bloom syndrome / Immunoglobulin gene / Class switching / B cell differentiation / C-myc gene / Common variable immunodeficietncy / Bloom症侯群 / C-myc遺伝子 / 無(低)ガンマグロブリン血症 / 遺伝子発現 / 刺激伝達機構 / B細胞 / RNAスプライス
Research Abstract

Immunological and genetical studies were carried out for agammaglobulinemia B cells.
Common variable immunodeficiency (CVI) is a heterogeneous group of diseases. Firstly, structure of immunoglobulin (Ig) gene was investigated using Ig probe and Southern blot analysis for germ line DNA of patients. No deletion and mutation was found in patients' IgH gene. Secondary, expression of Ig gene was investigated using northern blot analysis for lymphocytes of patients. In most patients, each class of Ig gene was not expressed. However, in a part of patients, C mu gene was expressed, but Cgamma gene was not expressed. B cell lines were prepared by EB virus. Rearrangement of Ig gene was investigated for patients' B cell lines. In some cases, Ig genes have been rearranged, whereas in the other cases Ig genes have not been rearranged. Moreover, there are abnormal chromatin structures in some common variale immunodeficiency.
Bloom syndrome patients have IgM deficiency. This was due to abnormal splicing in mu chain gene expression.
Selective IgA deficiency was due to abnormal class switching in immunoglobulin heavy chain genes.
Moreover, c-myc gene was expressed in some patients, but not in the other patients.
From our results, it became clear that there is heterogeneity in the pathogenesis of immunodeficiency (especially, a- or hypo-gammaglobulinemia).

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Naomi Kondo et al.: "Reduced secreted μmRNA synthesis in selective IgM deficiency of Bloom's syndrome." Clim Exp Immunol. 88. 35-40 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al.: "Long-term study of the immunodeficiency of Bloom's syndrome." Acta Paediatr. 81. 86-90 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Motoyoshi F,Kondo N,et al.: "Common variable immunodeficiency with increased surface IgM-positive double-bearing B cells." Scand J Immounol. 36. 21-26 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al.: "Accelerated expression of secreted α-chain gene in anaphylactoid purpura." J Clin Immunol. 12. 193-196 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Mori S,Kondo N,et al.: "Diversity in DNA rearrangements and in RNA expressions of immunoglobulin gene on common variable immunodediciency." E.J.Immunogenetics. 19. 273-285 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al.: "Failure of c-myc gene expression in B Cells of some patients with common variable immunodeficiencies." E.Clim Immunogenetics. 9. 109-116 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al.: "Expression of the immunoglobulin heavy chain(H)genes in selective immunoglobulin deficiencies.〔Molecular approaches〕" Elsevir Science Publishers, 560 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "Suppression of immunoglobulin production of lymphocytes by intravenous immunoglobulin." J Clin Immunol. 11. 152-158 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hideo Kaneko et al: "Expression of immunoglobulin genes in common variable immunodeficiency." J Clin Immunol. 11. 262-267 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "Insulin-dependent diabetes developed in a young man with Bloom's syndrome." Clinical Genetics. 40. 251-252 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Ryousuke Inoue et al: "Chediak-Higashi syndrome: report of a case with an ovarian tumor." Clinical Genetics. 39. 316-318 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shinji Shinoda et al: "Proliferative responses of CD4^+ T cell population to ovalbumin in patients with atopic dermatitis who are sensitive to hen's egg" Acta Paediatr. 81. 896-901 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "Failure of c-myc gene expression in Bcells of some patients with common variable immunodeficiency" Exp Clin Immunogenet. 9. 109-116 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "Reduced secreted mu mRNA synthesis in selective IgM deficiency of Bloom's syndrome" Clin exp Immunol. 88. 35-40 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "The role of T lymphocytes in patients with food-sensitive atopic dermatitis" J Allergy Clin Immunol. 91. 658-668 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hiroatsu Agata et al: "Effects of elimination diets on proliferative responses of lymphocytes in patients with atopic dermatitis who are sensitive to foods" J Allergy Clin Immunol. 91. 668-679 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al: "Expression on immunoglobulin heavy chain genes in selective immunoglobulin deficiency" Elsevir Science Pub. 131-137 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Naomi Kondo et al.: "Reduced secreted μmRNA synthesis in selective IgM deficiency of Bloom's syndrome." Clin Exp Immunol. 88. 35-40 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naomi Kondo et al.: "Long-term study of the immunodeficiency of Bloom's syndrome." Acta Paediatr. 81. 86-90 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Motoyoshi F,Kondo N,et al.: "Common variable immunodeficiency with increased surface IgM-positive double-bearing B cells." Scand J Immunol. 36. 21-26 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naomi Kondo et al.: "Accelerated expression of secreted α-chain gene in anaphylactoid purpura." J Clin Immunol. 12. 193-196 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Mori S,Kondo N,et al.: "Diversity in DNA rearrangements and in RNA expressions of immunoglobulin gene on common variable immunodediciency." E.J.Immunogenetics. 19. 273-285 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naomi Kondo et al.: "Failure of c-myc gene expression in B Cells of some patients with common variable immunodeficiencies." E.Clin Immunogenetics. 9. 109-116 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naomi Kondo et al.: "Expression of the immunoglobulin heavy chain (H) genes in selective immunoglobulin deficiencies." Elsevir Science Publishers, 560 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Naomi Kondo,et al: "Suppression of immunoglobulin production of lymphocytes by intravenous immunoglobulin" J Clin Immunol. 11. 152-158 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hideo Kaneko,Naomi Kondo,et al: "Expression of immunoglobulin genes in common variable immunodeficiency" J.Clin Immunol. 11. 262-267 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naomi Kondo,et al: "Insulinーdependent diabetes dereloped in a young man with Bloom´s syndrome" Clin Gene. 39. 251-252 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naomi Kondo,et al: "Longーterm study of the immunodeficiency of Bloom´s syndrome" Acta Paediatr(Scand). 81. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naomi Kondo,et al: "Reduced secreted μmRNA synthesis in selective IgM deficiency of Bloom's syndrome" Clin exp Immunol. 87. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Naomi Kondo,et al: "Failure of cーmyc gene expression in B cells of some patients with common variable immunodeficiencies" Exp Clin Immunogenetics. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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