• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of mechanism of desensitization of contact dermatitis

Research Project

Project/Area Number 03670521
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KATAYAMA Ichiro  Tokyo Medical & Dental Univ.Sch.Med.Asso.Prof., 医学部, 助教授 (80191980)

Co-Investigator(Kenkyū-buntansha) MATSUNAGA Tsuyoshi  Tokyo Medical & Dental Univ.Sch.Med., 医学部, 助手 (50239050)
YOKOZEKI Hiroo  Tokyo Medical & Dental Univ.Sch.Med., 医学部, 講師 (90210608)
西岡 清  東京医科歯科大学, 医学部, 教授 (20077647)
浅賀 洋一  東教医科歯科大学, 医学部, 助手 (40222567)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
KeywordsContact Dermatitis / Hapten amino acid / Desensitization / Macrophage / Langeshans cell / ClassII axtigless / Cell adhesion molecule / Mast cell / ハプチンアミノ酸 / パラフェニレンジアミン / 脱感作療法 / TNPーLysine / マウス
Research Abstract

Prophylaxis of occupational and uncontrolled contact dermatitis is one of the most important subjects in corrent clinical dematology. These include, induction of tolerance by feeding or intra-muscular administration of allergic substance, photochemotherapy or possible inhibition of efferent limb of contact sensitivity by administration of antibodies against cell adhesion molecules or of extracellular matrix peptides. However, mechanisms of these approach still remained unclear and their effects are cntrovercial.
For this purpose, we have studied the mechanism of desensitization, and have been trying to establish the in vivo model system using rodent contact sensitivity to simple chemical compounds by local administration of TNP-lysine or Oxasolone-glycine. This method induced longlasting desensitized state in murine contact sensitivity and raised the possibility of prophylaxis of contact dermatitis in clinical dermatology. Inhibition of T cell receptor and peptide binding groove on macrophage is thought to be the targets of this inhibition. Toxity, effect of other haptens and much precise mechanisms should be clarified in the future study.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Katayama I.Yokozeki H & Nishioka K.: "Mast cell derived mediators induce for lichenified skin lesion formation epidermal cell proliferation:Clue in atopic dermatitis." Int Arch Allerg 1992 Immunol.98:410-414.98. 410-414 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yokozeki H.Katayama I,Nishioka K.Kinoshita M & Nishiyama S.: "The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx" J Dermatol.1993 19:964-967.19. 964-967 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Katayama I.Yokozeki H & Nishioka K: "Induction and characterization of mast cell colonies byculture super-natant of retinoic acid treated mouse keratinocytes." Int Arch Allergy 1993 Immunol.100:328-332.100. 328-332 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 横関博雄,片山一朗,西岡清,西山茂夫: "歯科金属が原因と考えられた異汗性湿疹の5例" 日皮会誌1993 103:649-654.103. 649-654 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 横関博雄,片山一朗,西岡清,西山茂夫: "ハプテン結合Pam細胞を用いたIn vitroでのエフェクターTリンパ球の誘導" 日皮会誌1993 103:493-499.103. 493-499 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato T.Yokozeki H,Katayama I,Nishioka K: "Down regulation of murine contact sensitivity by hapten amino acid derivatives" Int Arch Allerg 1993 Immunol 102:94-100.102. 94-100 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Katayama, I.Yokozeki, H & Nishioka, K.: "Mast cell derived mediators induce epidermal cell proliferation : Clue ofr lichenified skin lesion formation in atopic dermatitis." Int Arch Allerg Immunol.98. 410-414 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yokozeki H., Katayama I., Nishioka K., Kinoshita M., & Nishiyama S.: "The role of metal allergy and local hyperhidrosis in the pathogeneses of pompholyx" J Dermatol.19. 964-967 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Katayama I., Yokozeki H.& Nishioka K.: "Induction and characterization of mast cell colonies byculture supernatant of retinoic acid treated mouse keratinocytes" Int Arch Allergy Immunol.100. 328-332 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yokozeki H., Katayama I., Nishioka K., Nishiyama S.: "Five cases of pompholyx induced by dental metals" Jap.J.Deim.103. 649-654 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yokozeki H.Katayama I.Nishioka K.Nishiyama S.: "Induction of effector T cells by hapten coujugates Pam sells in vitro" Jap.J.Deim.103. 493-499 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Sato T., Yokozeki H., Katayama I., Nishioka K.: "Down regulation of murine contact sensitivity by hapten amino acid derivatives." Int Arch Allerg Immonol.102. 94-100 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 横関博雄、片山一朗、西岡清: "ニッケルに陽性反応を呈した汗疱" 皮膚診療. 15. 511-514 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yokozeki H,Katayama I,Nishioka K,Kinoshita M&Nishiyama S.: "The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx" J Dermatol.19. 964-967 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Katayama I,Yokozeki H&Nishioka K: "Induction and characterization of mast cell colonies byculture supernatant of retinoic acid treated mouse keratinocytes." Int Arch Allergy Immunol.100. 328-332 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 横関博雄、片山一朗、西岡清、西山茂夫: "歯科金属が原因と考えられた異汗性湿疹の5例" 日皮会誌. 103. 649-654 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 横関博雄、片山一朗、西岡清、西山茂夫: "ハプテン結合Pam細胞を用いたIn vitroでのエフェクターTリンパ球の誘導" 日皮会誌. 103. 493-499 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Sato T,Yokozeki H,Katayama I,Nishioka K: "Down regulation of murine contact sensitivity by hapten amino acid derivatives" Int Arch Allerg Immunol. 102. 94-100 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 片山 一朗: "脱感作療法による接触皮膚炎の抑制機序の解析とその臨床応用" 病態生理. 11. 722-723 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 田中 厚: "メチレンビスアクリルアミド取り扱い者に見られた接触皮膚炎" 皮膚. 34増13. 161-164 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] I.Katayama: "Mast cell derived mediafors induce cpidermal cell proliferation:Clue for 1ichenified skin lesion formation in afopic dermatitis." International Archives Allergy and Immunalogy. 98. 410-414 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] I.Katayama: "Mechanims of desensitization in contact sensitivity" J.Dermafology.

    • Related Report
      1992 Annual Research Report
  • [Publications] Katayama I,Nishiyama S,Nishioka K: "Clinical and histological analysis of labial lip biopsy in Sjogren syndrome" J Dermatol. 18. 25-30 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katayama I,Asai T,Nishiyama S,Nishioka K.: "Lymphocyte response to staphylococcal enterotoxin B in patients with annular erythema associated with Sjogren syndrome." J Dermatol. 18. 63-68 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katayama I,Tanei R,Yokozeki H,Nishioka K,Doi Y: "Induction of eczematous skin reaction DNP IgE antibody:Possible implication in experimentally induced hyperplastic for skin lesion formation in atopic skin of Balb/C mice by monoclonal antiー dermatitis" Int Arch Allerg appl Immunol. 93. 148-154 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Katayama I,Hamada U,Otoyama K,Nishioka K,Nishiyama S: "Identification of antiphospholipid antibodies in systemic lupus erythematosus on thin layer chromatography and immunostaining" Arch Derm Res. 283. 411-413 (1991)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi