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Human Dermal melanocyte and dermal melanocytosis

Research Project

Project/Area Number 03670526
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionKumamoto Universiti School of Mediicine

Principal Investigator

ONO Tomomichi  KUMAMOTO UNIV., SCHOOL OF MEDIXINE, Professor, 医学部, 教授 (10040586)

Co-Investigator(Kenkyū-buntansha) HIRAI Syunji  KUMAMOTO UNIV., SCHOOL OF MEDIXINE, Instructor, 医学部, 助手 (10228760)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywordshuman dermal melanocyte / type VI collagen / late-onset dermal melanocytosis / IV型コラーゲン / メラノサイト / BrdU / VI型コラ-ゲン
Research Abstract

1) In the skin of the back of six adults, we have confirmed the persistence of dermal melanocytes light microscopically as well as electron microscopically. It has been assumed that a redution in the population dencity of dermal melanocytes due to the growth of the dermis both horizontally and vertically is responsible for the desappearance of Mongolian spots, and not the disappearance of dermal melanocyts.
2) The melanocytes in crab-eating monkeys exist in the sheath-like network of melanocytes around the veins. We also found dermal melanocytes around the veins in humans, especially in blue nevi.
3) For the identification of dermalmelanocytes, the presence of the extracellular sheath is important. We have discovered that the extracellular sheath contains type VI collagen immuno-electron microscopically, and this sheath sometimes encircles the elastic fibers.
4) We have studied late-onset dermal melanocytoses such as acquired Nevus-Ota like pigmentation clinicopathologically and discovered and proposed the concept of late-onset dermal melanocytosis characteristically appearing in the upper back of aged persons.( Late-onset upper back dermal melanocytosis)
5) We have discovered dermal melanocytes in the stroma of basal cell carcinoma for the first time, an interesting finding in view of the close relationships between collagen fibers and fibroblasts.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Tomomichi Ono: "Late Onset Dermal Melanocytosis:An Upper Back Variant" J.of Dermatol.18. 79-103 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takehiko Nakamura: "MALIGUNANT SCHWANNOMA ASSOCIATED WITH XERODERA PIGMENTOSUM" J.of American Academy of Dermatology. 25. 349-353 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 吉井章: "悪性黒色腫におけるType IVコラーゲン、ラミニンの存在様式についての免疫組織学的検討" 日皮会誌. 102. 471-478 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 山村文衛: "悪性黒色腫と鑑別を要した青色母斑-所属リンパ節に黒色病変を併発した1例-" Skin Cancer. 7. 197-199 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshiro Kageshita: "Analysis of expression and soluble form of intercellular adhesion molecule-1 malignant melanoma" J.Dermatol. 19. 836-840 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ichiro Kikuchi: "Regressing Novoid Nail Melanosis in Child hood" Dermatology. 186. 88-93 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 中島孝・石原和之: "腫瘍鑑別診断アトラス-色素性腫瘍-" 文光堂, 219 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Tomomichi Ono: "Late Onset Dermal Melanocytosis : An Upper Back Variant" J.of Dermatol. 18. 97-103 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takehiko Nakamura: "MALIGUNANT SCHWANNOMA ASSOCIATED WITH XERODERMA PIGMENTOSUM" J.of A.A.D. 25. 349-353 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Akira Yoshii: "Immunohistochemical Localization of Type IV Collagen and Laminin in Primary and Metastatic Malignant Melanoma" Jpn J Dermatol. 102. 471-478 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fumie Yamamura: "Regional Lymph Node Melanocytosis In A Patient With blue nevus" Skin cancer. 7. 197-199 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Toshiro Kageshita: "Analysis of expression and soluble form of intercellular adhesion molecule-1 maignant melanoma" J.Dermatol. 19. 836-840 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ichiro Kikuchi: "Regressing Nevoid Nail Melanosis in Child hood" Dermatology. 186. 88-93 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Ichiro Kikuchi: "Regressing Nevoid Nail Melanosis in child hood" Dermatology. 186. 88-93 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野友道: "基底細胞癌(I)-基底細胞癌の色素沈着について-" 西日皮膚. 55. 78-85 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野友道: "真皮メラノサイト" 皮膚科の臨床. 35. 675-682 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 小野友道: "皮膚悪性腫瘍の電顕所見-その見方と考え方第一歩-" 日本皮膚科学会雑誌:皮膚科専門医テキスト. 1-25 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Toshiro Kageshita: "Clinical relevance of ICAM-1 expression in primary lesions and serum of patients with malignant melanoma" Cancer Res.53. 4927-4932 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Toshiro Kageshita: "Analysis of the antigenic profile of mucous melanoma lesions with anti-melanoma associeataed antigen" Melanoma Res.3 Supplement. 1. 85-85 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 中島孝・石原和之: "腫瘍鑑別診断アトラス-色素性腫瘍-" 文光堂, 219 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Ichiro Kikuhci: "Regressing Nevoid Nail Melanosis in Childhood" Dermatology. 186. 88-93 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小野 友道: "基底細胞癌(1)-基底細胞癌の色素沈着について-" 西日本皮膚科. 55. 78-85 (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小野 友道: "真皮メラノサイト" 皮膚科の臨床. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tomomichi Ono: "Practical and Investigation Dermatology" JICA, 555 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 小野 友道: "カラー図説皮膚腫瘍" 金原出版, 452 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tomomichi Ono: "Late Onset Dermal Melanocytosis An Upper Back Variant" J.Dermatology. 18. 40-46 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Kenichi Kayashima: "Spontaneous Regression In Merkel's cell(Neuroendocrine)Carcinoma of the Skin" Arch.Dermatology. 127. 550-553 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Takehiko Nakamura: "Malignant schwannoma associated with xeroderma pigmentosum in a patient belonging to complementation group D" J.Am.Acad.Dermatology. 25. 349-353 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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