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Preliminary study of monochromatic X-ray CT with synchrotron radiation

Research Project

Project/Area Number 03670538
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEDA Tohoru  Institute of Clinical Med, Univ.of Tsukuba Assistant Prof., 臨床医学系, 講師 (10197311)

Co-Investigator(Kenkyū-buntansha) AKATSUKA Takao  Dept.Electr.and Informat Egn, Yamagata University Prof., 工学部, 教授 (80091875)
ISHIKAWA Nobuyoshi  Institute of Clinical Med, Univ.of Tsukuba Associate Prof., 臨床医学系, 助教授 (10026932)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1992: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1991: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordssynchrotron radiation / computed tomography / monochromatic X-ray / biomedical diagnosis / high resolution / functional analysis / synchrotoron radiation / computed tomography / biomedical diagnosis / cerebral blood flow / nuclear medicine / functional analysis
Research Abstract

From 1990, a biomedical SR-CT to detect tracer material up to a few mug iodine/ml is being developed for functional evaluations of regional blood flow and metabolism of the organs corresponding to their anatomical structures. The feasibility test of our SR-CT system is performed on phantom and rats.
[Methods and material] SR-CT system consists of a rotating X-ray shutter, a silicon (111) channel-cut monochromator, a sample rotating system, X-ray slits and a detector system. Energy of monochromatic X-rays is set at 33.28 keV.Exposure time of each projection is set at 25 msec. The number of projection is 90. Experiment beam line is BLNE 5A of Tristan Accumulation Ring in Tsukuba. Imaging plate(IP) is used as the X-ray detector. The IP data is read by laser beam and digitized by 10 bit analog-to-digital converter (BAS-2000). The spot size of laser is 100 mum^2 with a 10 bit depth. CT image is reconstructed by the post-processing computer(HP 9000). Objects are small rod and brain phantom filled with an iodine, and rats.
[Results] The image of above iodine K-edge shows the hole and ditch of phantom filled with iodine clearly. The 44.8 mum/ml iodine can be detected faintly. This concentration corresponds well to the theoretical value (59.7 mug/ml iodine). But this detectable dose of iodine is about 10 times larger than that of our purpose (5 mug/ml iodine). Main reason is poor dynamic range of laser reading system of IP.So to improve the system for detecting very low contrast agent, the sensor with wide dynamic range(50000) is needed.
CT image of rat skull with 100 mum spatial resolution showed fine structures of nose, mandibular bone and skull. Final goal of this SR-CT is to detect 5 mug/ml iodine and to obtain less than 5 mm spatial resolution of the brain image like a PET study.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] Takeda T.: "High spatial resolution CT with a synchrotron radiation system." J.Computer Assisted Tomography. 18. 98-101 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 武田徹: "放射光を利用した微量元素分析型CT開発" 新医療. 230. 72-76 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Zeniya T: "Detectability of tracer materials in synchrotron radiation computed tomography" Medical Imaging Technology. 11. 405-406 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 武田徹: "放射光を用いた微量元素検出型単色X線CTの開発" INNER VISION. 8. 120-124 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 武田徹: "放射光CTの開発動向" Med.Imag.Tech.11. 621-627 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T: "Synchrotron radiation computed tomography for biochemical use" Photon Factory Activity Report. 10. 411 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T., Itai Y., Hayashi K., Nagata Y., Yamaji H., Hyodo K: "High spatial resolution CT with a synchrotron radiation system." J.Computer Assisted Tomography. 18. 98-101 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Itai Y,Takeda T: "Application of Synchrotron Radiation to Medicine Two-Dimensional Intravenous Caronary Arteriography and Monochromatic X-Ray Computed Tomography" INVESTIGATIVE RADIOLOGY. 28(3). 158-159 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Zeniya T,Takeda T,Hyodo K,Akatsuka T,Hiranaka Y,Yuasa T,Tamura A,Uchida A,Wu J,Ishikawa N,Itai Y: "Detectability of tracer materials in synchrotron radiation computedtomography" Medical Imaging Technology. 11. 405-406 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Zeniya T,Hyodo K,Akatuska T,Yuasa T,Hiranaka Y,Wu J,Ishikawa N,Itai Y: "Synchrotron radiation computed tomography for biochemical use" Photon Factory Activity Report. 10. 411 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Zeniya T,Hyodo K,Akatsuka T,Yuasa T,Hiranaka Y,Uchida A,Tamura Y,Wu J,Ishikawa N,Itai Y: "Development of a monochromatic X-ray computed tomography with synchrotron radiation to detect tracer materials. Peoceedings of the Workshop on Medical Apllications" Using Synchrotron Radiation. Sep.4-6th. 1-11 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Akatsuka T,Hyodo K,Itai Y,Hiranaka Y,Zeniya T,Yuasa T,Satoh M,Wu J,Ishikawa N,Nemoto H: "Synchrotron radiation computed tomography for biomedical use" Proc.of 4th International Conference on Biophysics and Synchrotron Radiation. 9. 336 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Itai Y,Umetani K,Ueda K,Akisada M: "SR Intravenous coronary arteriography by an iodine filter method" Proc.of 4th International Conference on Biophysics and Synchrotron Radiation. 9. 341 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Akatsuka T,Hyodo K,Hiranaka Y,Zeniya T,Yuasa T,Satoh M,Wu J,Ishikawa N,Itai Y: "Synchrotron radiation X-ray computed tomography to detect tracer material" Med.Imag.Tech.10(3). 299-300 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T,Akatsuka T,Hyodo K,Itai Y,Hiranaka T,Zeniya T,Yuasa T,Sato M,Ishikawa N,Yoshioka H,Nemoto H.: "Synchrotron radiation computed tomography for biomedical use preliminary report with phantom." Photon Factory Activity Report. 9. 312 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Takeda T.: "High spatial resolution CT with a synchrotron radiation system." J.Computer Assisted Tomography. 18. 98-101 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] 武田徹: "放射光を利用した微量元素分析型CT開発。" 新医療. 230. 72-76 (1994)

    • Related Report
      1993 Annual Research Report
  • [Publications] Zeniya T: "Detectability of tracer materials in synchrotron radiation computedtomography" Medical Imaging Technology. 11. 405-406 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 武田 徹: "放射光を用いた微量元素検出型単色X線CTの開発" INNERVISION. 8. 120-124 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 武田 徹: "放射光CTの開発動向" Med.Imag.Tech.11. 621-627 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeda T: "Synchrotron radiation computed tomography for biochemical use" Photon Factory Activity Report. 10. 411 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Takeda T.,Akatsuka T., et al;: "Synchrotron radiation computed tomography for biomedical use.:Preliminary report with phantom" PF Activity Report. 9. 312- (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takeda T,et al: "Synchrotron radiation computed tomography to detect tracer material." Medical Imaging Technology. 10. 299-300 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takeda T,et al: "Synchrotron radiation CT for biomedical use." Proceeding of 4th Intemational Congress on Biophysics and Synchrotron Radiation. 336- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 銭谷 勉、武田 徹、他: "生体機能分析のための微量標織物質検出ー放射光単色X線CT装置の試作ー" 計測自動制御学会東北支部第136回研究集会資料. 136-1. 1-10 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 武田 徹、板井 悠二、他: "放射光CTを利用した生体機能画像作製および実験的検討" INNERVISION. 7. 19-20 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Takeda T,et al: "Synchrotron radiation computed tomography for biomedical use" PF activity report. 8. 348 (1990)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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