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The role of neural transplantation on the cholinergic neuron denavated Alzheimer's disease model

Research Project

Project/Area Number 03670566
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionKagawa Medical School

Principal Investigator

HOSOKAWA Kiyoshi  Kagawa Med.Sch.Vice-President, 副学長 (70093698)

Co-Investigator(Kenkyū-buntansha) TOKUDA Masaaki  Kagawa Med.Sch., Med.Research Associate, 医学部, 助手 (10163974)
ITANO Toshifumi  Kagawa Med.Sch., Med.Research Associate, 医学部, 助手 (60145042)
MATSUI Hideki  Kagawa Med.Sch., Med Associate Professor, 医学部, 助教授 (30157234)
HATASE Osamu  Kagawa Med.Sch., Med.Professor, 医学部, 教授 (50033220)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsAlzheimer's disease / Neural Transplantation / Neurotrophic factors / 痴呆モデル / 脳神経細胞 / 移植 / コリン作動性ニューロン / アルツハイマ-病 / 脳神経細胞移植 / コリン作働性ニュ-ロン
Research Abstract

Alzheimer's disease is one of the most severe dementia with the neurodegeneration. However, it is still uncertain about its cause, etiology and progression. This disease have been mainly reported in western coutries, but, gradual and steady increase of this disorder are found in Japan. Two possible approaches are suggested. One is the analysis of cause and the other is the development of treatment. Some studies clearly showed that cholinergic neuron was degenerated significantly. According to the loss of these neurons, one of the possible treatment is the transplantation of cholinergic neurons. It is also suggested that the application of some neurotrophic factors(NTFs) must promote the regeneration of cholinergic neurons. Our studies were focused on the hippocampus which contains the cholinergic neurons and is closely related the memory and learning. We showed that two major NTFs (IGF-I and bFGF) have potent activities to repair the injury of the hippocampus. It is also proved that neural transplantation is very effective on the improvement of memory deficit. The conditions of garft and host are very important. Neural transplantation is also effective in theepileptic model that is called kindling. Proper neural transplantation and NTFs treatment are both effective to improve the amnesia. We sugested the possibility to apply these method to the clinicaltreatments.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Yamaguchi,Funimori: "Increase of extracellular insulin-like growth factor I(IGF-I)concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa,Mutsuo: "Effects of neurotrophic factors in brain injury." Advances in Neurotrauma Res.4. 42-46 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyamoto,Osamu: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat." Brain Research. 603. 143-147 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyamoto,Osamu: "Exogenous basic fibroblast growth factor enhance spouting of acetylcholinesterase posotive fibers in denervased rat hippocampus." Acta Medica Okayama. 47. 139-144 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa,Mutsuo: "Mutual interaction between host and Graft tissues in the embryonic neural transplantation." Neuro Report. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa,Mutsuo: "Recent Advance Neurotraumatology" Nakamura,N.,Hashimoto,T.,Yasue,M.(Eds.)Springer-Verlag, 4 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yamaguchi, Fuminori et al.: "Increase of extracellular insulin-like growth factor I(IGF-I) concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa, Matsuo et al.: "Effects of neurotrophic factors in brain injury" Advances in Neurotrauma Res.4. 42-46 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyamoto, Osamu et al.: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat." Brain Research. 603. 143-147 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Miyamoto, Osamu et al.: "Exogenous basic fibroblast growth factor enhance spouting of acetylcholinesterase posotive fibers in denervased rat hippocampus." Acta Medica Okayama. 47(3). 139-144 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa, Mutsuo et al.: "Mutual interaction between host and Graft tissues in the embryonic neural transplantation." NeuroReport. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Fujisawa, Mutsuo: Physiological roles of neurotrophic factors in brain injury.Recent Advance Neurotraumatology, Nakamura, N., Hashimoto, T., Yasue, M.(Eds.)Springer-Verlag., 236-239 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yamaguchi,Fuminori: "Increase of extracellular insulin-like growth factor I(IGF-I) concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fujisawa,Mutsuo: "Effects of neurotrophic factors in brain injury." Advances in Neurotrauma Res.4. 42-46 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyamoto,Osamu: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat." Brain Research. 603. 143-147 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Miyamoto,Osamu: "Exogenous basic fibroblast growth factor enhance spouting of acetylcholinesterase posotive fibers in denervased rat hippocampus." Acta Medica Okayama. 47. 139-144 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Fujisawa,Mutsuo: "Mutual interaction between host and Graft tissues in the embryonic neural transplantation." Neuro Report. (in press).

    • Related Report
      1993 Annual Research Report
  • [Publications] Fujisawa,Mutsuo: "Recent Advance Neurotraumatology" Nakamura,N.,Hashimoto,T.,Yasue,M.(Eds.)Springer-Verlag, 4 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] F. Yamaguchi: "Increase of extracellular insulin-like growth factor I (IGF-I) concentration following electrolytical lesion in rat hippocampus" Neuroscience Letters. 128. 273-276 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] M. Kagawa: "Treatment of brain edema with arginine vasopressin receptor antagonist." Advances in Neurotrauma Research. 3. 75-79 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Y. Minamoto: "In vivo microdialysis of amino acid neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Research. 573. 345-348 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] N. A. Janjua: "Famillial increase in plasma glutamic acid in epilepsy" Epilepsy Research. 11. 37-44 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] L. J. M. P. Moia: "Identification of a src family protein specifically expressed in rat astrocytes by immunohistochemistry and double immunofluorescent study" Brain Research. 585. 283-286 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] O. Miyamoto: "Effect of embryonic hippocampal transplantation in amygdaloid kindled rat" Brain Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Fuminori Yamaguchi: "Increase of extracellular insulinーlike growth factor I(IGFーI) concentration following electrolytical lesion in rat hippocampus." Neuroscience Letters. 128. 273-276 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Mikio Sugimoto: "Isolation and Sequence of rat testis cDNA for a calcium binding polypeptide similar to regulatory subunit of calcineurin." Biochem.Biophys.Res.Commun.180. 1476-1482 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Hajime Nishio: "Indentification of testis specific calcineurin β subunit isoform by a monoclonal antibody and detection of specific six amino acid sequence." Biochem.Biophys.Res.Commun.182. 34-38 (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yuichiro Minamoto: "In vivo microdialysis of amino neurotransmitters in the hippocampus in amygdaloid kindled rat." Brain Research. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] HeungーChin Cheng: "A Synthetic peptide derived from p34^<cdc2> is a specific substrate of srcーfamily tyrosine kinases." Journal of Biological Chemistry. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Osamu Miyamoto: "Exogenous basic fibroblast growth factor and growth factor enhance sprouting acetylcolinesterase positive fibers in denervated hippocampus." Neuroscience Letters.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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