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SIGNIFICANCE OF NEUROPEPTIDE Y IN EARLY DIAGNOSIS AND AS A PROGNOSTIC FACTOR OF NEUROBLASTOMA

Research Project

Project/Area Number 03670577
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

HAYASHI Yutaka  TOHOKU UNIVERSITY SCOOL OF MEDICINE, DEPARTMENT OF PEDIATRIC SURGERY, ASSOCIATE PROFESSOR, 医学部, 助教授 (40125638)

Co-Investigator(Kenkyū-buntansha) TOTUNE Kazuto  TOHOKU UNIVERSITY SCOOL OF MEDICINE, SECOND DEPARTMENT OF INTERNAL MEDICINE, ASS, 医学部・附属病院, 助手 (10217515)
MURAKAMI Osamu  TOHOKU UNIVERSITY SCOOL OF MEDICINE, SECOND DEPARTMENT OF INTERNAL MEDICINE, ASS, 医学部・附属病院, 助手 (00157744)
OHI Ryoji  TOHOKU UNIVERSITY SCOOL OF MEDICINE, DEPARTMENT OF PEDIATRIC SURGERY, PROFESSOR, 医学部, 教授 (50004734)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsNEUROBLASTOMA / NEUROPEPTIDE Y / TUMOR MARKER / MASS SCREENING / ニュー ペプチドY / マス発見群 / ニュ-ロペプチドY / 腫瘍マ-カ- / マススクリ-ニング
Research Abstract

Plasma neuropeptide Y(NPY) concentrations were detected in 44 cases with neuroblastoma (NB) and 48 cases without NB.Sensitivity and specificity of NPY on the diagnosis of NB were 84% and 92%, respectively. NPYs in NB cases were significantly lower in cases of younger than 1-year-old than in older cases, in granglioneuroma than in neuroblastoma, in favorable histology (FH) than in unfavorable histology (UH), in cases detected by mass screening than in mass screening negative cases, in early staged cases than in advanced cases, respectively. NPYs did not correlated with any other tumor markers including VMA and HVA in urine, plasma NSE, LDH and ferritin. NB cases were divided by the plasma NPY concentrations (Group 1 : < 1,000 pg/ml, Group 2 : 1,000-3,000 pg/ml, Group 3 : > 3,000 pg/ml) to analyze the relationship between NPYs and prognosis. Survival rate of Group 1 was significantly better than those of Group 2 and 3. All of the patients of Group 1 survived without any evidence of disease. The prognosis of FH cases in Group 1 was excellent but the prognoses of FH in Group 2 and 3 were not good. Four patients with amplified N-myc were classified in Group 2 or 3.
Urinary NPY was measured and NPY like immunoreactivity from 40 to 200 pg/ml in concentration was detected. It was found that major component of NPY in urine shifted to low molecular wieght area. It was considered NPY to be metabolized at the urinary system and to be possible to measure urinary NPY concentrations.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] Yutaka Hayashi: "Further analysis of significance of neuropeptide Y in neuroblastoma" Abstract of the 26th pacific association of pediatric surgeons. 26. 131 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Hayashi Y, Ohi R, Takahashi K et al: "Further analysis of significance of neuropeptide Y in neuroblastoma" Proceeding of the 26th annual meeting of Pacific Association of Pesiatric Surgeons.26. 131 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yutaka Hayashi: "Further analysis of significance of neuropeptide y in neuroblastoma" Abstract of the 26th pacific association of pediatric surgeons. 26. 131 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 林 富: "神経芽腫の予後因子としての血漿neuropeptideyの有用性" 小児外科. 23. 392-398 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yutaka Hayashi: "Significance of plasma Neuropeptide y(NPY) in Diagnosis and Prognosis of Neuroblastoma" Progress in Clinical and Biological Research. 366. 359-365 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 林 富: "神経芽腫の腫瘍マーカー及び予後因子としての血漿NPy濃度の意義 特に嶋田分類との比較検討" 小児がん. 29. 306-309 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 林 富: "神経芽腫の予後因子としての血漿neuropeptide Yの有用性" 小児外科. 23. 392-398 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yutaka Hayashi: "Significance of Plasma Neuropeptide Y(NPY)in Diagnosis and Prognosis of Neuroblastoma" Progress in Clinical and Biological Reseerch. 366. 359-365 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 林 富: "神経芽腫の腫瘍マ-カ-及び予後因子としての血漿NPY濃度の意義特に嶋田分類との比較検討" 小児がん.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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