| Project/Area Number |
03670587
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
KAMIKAWA Yasuaki Okayama University Medical School, First Department of Surgery Assistant Professor, 医学部附属病院, 講師 (00152851)
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| Co-Investigator(Kenkyū-buntansha) |
NAOMOTO Yoshio Okayama University Medical School, First Department of Surgery Instructor, 医学部附属病院, 助手 (00237190)
INOUE Fumiyuki Okayama University Medical School, First Department of Surgery Instructor, 医学部附属病院, 助手 (90223271)
ORITA Kunzo Okayama University Medical School, First Department of Surgery Professor, 医学部, 教授 (20033053)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | monoclonal antibody / metastasis / cancer / 血管内皮 / 拒絶反応 |
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| Research Abstract |
Recently monoclonal antibodies (MAbs) capable of recognizing metastatic tumors have been reported. In order to obtain such monoclonal antibodies, BALB/c mice were immunized with highly metastatic tumor cell line. MAb II-28 and 243-5 obtained by immunization with metastatic LoVo-N3 inhibited the lung metastasis of RPMI4788 and the liver metastasis of LoVo-N3. The MAbs did not affect the cell growth in vitro. The metastasis inhibitory effect was supposed not due to cell damage mediated by ADCC and complement-dependent cytotoxicity. The 40kDa and 50kDa molecules recognized by MAb II-28 and 243-5 respectively are considered to play an important role in metastasisi of the cells.
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