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Metabolic Alterations associated with Cancer Cachexia An analysis of mechanisms from microstructure and molecular biology-

Research Project

Project/Area Number 03670593
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionYokohama City University

Principal Investigator

NOGUCHI Yoshikazu  横浜市立大学, 医学部, 講師 (50180724)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Akihiko  横浜市立大学, 医学部, 教授 (20045975)
ITO Takaaki  横浜市立大学, 医学部, 講師 (70168392)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Keywordsinsulin resistance / lipoprotein lipase / phosphoenolpyruvate carboxykinase / TNF alpha / Interleukin-2 / Bezafibrate / TNFα / InterCoukin-2 / Bazafibrate / MCA sarcoma / cancer cachexia / morphometry / phosphenolpyruvate cavboxylcinase
Research Abstract

1.糖新生系の律速酵素であるphosphoenolpyruvate carboxykinaseの変化におよぼずinsulin,glucose濃度の影響とtriglyceride clearanceのkey regulatory enzymeであるlipoprotein lipaseのinsulinに対する反応を細胞レベルで検討した。
LPL活性値低下は、high physiologic insulin concentrationにも、super-physiologic insulin concentrationでも反応性が低下しておりinsulin sensitivityと共に、responsivenessも低下していることが判明した。(AACR 1994 in Floridaにて発表、日本外科学会雑誌速報94:131,1994)。
molecular levelでの検討は継続中である。
2.悪液質に関与するmediatorの研究
Fisher 344 ratにTNF aipha,IL-2を投与、各種代謝変動におよぼす影響を malic enzyme,phosphoenolpyruvate carboxykinase,lipoprotein lipaseの活性値の変化より検討した。
TNF alphaおよびIL-2のKey regulatory enzymeに及ぼす効果は、担癌時に認められるそれらとは明らかに異なっており、これらcytokineがcancer cachexiaのmediatorとして作用している可能性は少ないと考えられた。(Surgery Today23:621-625-1993).
3.担癌ラットにおけるLPL活性値刺激の効果、prostagrandin cascadeの関与、インダシンによる遮断担癌時にみとめられるLPL活性値の低下は高脂症治療薬であるbezafibrateにより上昇させる事が可能であることが判明した。(日本外科学会雑誌速報93:759,1993)。
インダシンによる効果は、著明では無かった。

Report

(4 results)
  • 1994 Annual Research Report
  • 1993 Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] YOSHIKAWA T: "Effects of tumor vemovel and body weight loss on insulin vesistance in cancer pgtients" Surgery. (予定). (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野口芳一: "担癌時の脂質代謝に及ぼすインスリン抵抗性の影響" 日本外科学会雑誌. 94. 131- (1994)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野口芳一: "担癌生体におけるinsulin resistance" Japanese Jornal of Parentard 〓 Enterd Num'fion. 15. 609-614 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] NOGUCHI Y.: "Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity" Jornal of Surgical Research. 55. 357-363 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] NOGUCHI Y.: "The Effects of a Biological Respomse Modifier,OK-432,on Tumor-Induced AHerations in the Host Metabolism" Surgery Today. 23. 621-625 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] 野口芳一: "分子生物学レベルから見た担癌時に煮起される代謝異常" Medical Postgraduates. 31. 74-80 (1993)

    • Related Report
      1994 Annual Research Report
  • [Publications] YOSHIKAWA T: "Effects of tumor removal and body weight loss on insulin resistance in cancer patients" Surgery. (予定). (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 野口芳一: "担癌時の脂質代謝に及ぼすインスリン抵抗性の影響" 日本外科学会雑誌. 94. 131 (1994)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 野口芳一: "担癌生体におけるinsulin resistance" Japanese Journal of Parenterd Enterd Nutrition. 15. 609-614 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] NOGUCHI Y.: "Tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity" Journal of Surgical Research. 55. 357-363 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] NOGUCHI Y.: "The Effects of a Biological Response Modifier,OK-432,on Tumor-Induced A Herations in the Host Metabolism" Surgery Today. 23. 621-625 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 野口芳一: "分子生物学レベルから見た担癌時に惹起される代謝異常" Medical Postgraduates. 31. 74-80 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] YOSHIKAZU NOGUCHI et al: "Metabolic alterations in totally gaotreceomized patients-caloric intake and energy consumption-" Asian Journal of Surgery. 15. 97-102 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 野口 芳一他: "上部消化器癌患者における組織lipeprotein lipase活性値からみた術前高カロリー輸液の意義" 日本外科学会雑誌(速報). 93. 868- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉川 貫己 野口 芳一他: "癌の進展に伴う担癌患者の免疫能の変化-precachectos stateにおけるリンパ球サブセットの変動-" 外科と代謝.栄養. 26. 356-360 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 福沢 邦康 野口 芳一他: "核DNA量解折からみた残胃吻合部半石膜の特異性-残胃癌発生母他に関する検討-" 日本外科学会雑誌(速報). 93. 336- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Akira Tsuburaya YOSHIKAZU NOGUCHI et al: "C-erbB2 oncoprotein in relatively early stages of gantric carcinona-An innunohis to chemical study" Asian Journal of Surgery. 15. 164-167 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yoshikazu NOGUCHI at al: "Tumorーinduced Alterations in Tissue Lipoprotein Lipase Activity and mRNA" Cancer Research. 51. 863-869 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yoshikazu NOGUCHI at al: "Metabdic Alterations in Totally Gastredomized PationtsーCaloric lntake and Energy Consumptionー" Asian Journal of Surgery. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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