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Improvements for clinical application of radioimmunoscintigraphy

Research Project

Project/Area Number 03670614
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionFujita Health University (1992)
Nagoya University (1991)

Principal Investigator

WATANABE Tadashi  Fujita Health Univ., Medicine, Professor, 医学部, 教授 (20144157)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
KeywordsImmunoscintigraphy / CEA / Monoclonal antibody / Colon cancer / モノクロ-ナル抗体
Research Abstract

Imaging using radiolabeled monoclonal antibody(MAb) to tumorassociated antigen is potentially specific approach to qualitative diagnosis. We Produced MAbCEA102 against CEA by immunization with purified CEA, and applied to 20 cases with colorectal cancer. This method was useful to distinguish postoperative fibrosis from local recurrence. Another experiment was performed to investigate the specific accumulation of radiolabeled CEA102 using Fuji Computed Radiography(FCR). Autoradiogram by FCR showed predominant localization of ^<131>I-CEA102 in primary tumor and even small liver metastases. Although the above results demonstrated that radioimaging was useful to qualitative diagnosis, many technical problems confront its clinical application. In this study, we compared F(ab')2 fragments with whole lgG, and used ^<111>In as a radiotracer, and Emission CT as an extra scanner. F(ab')2 were eliminated from the circulation twice as fast as whole IgG, and demonstrated clear image on the 1st day after injection, but 3rd to 4th day in whole IgG. ^<111>In was accumulated in liver more than 1 week, but suitable tools to diagnose local recurrence of rectal cancer using Emission CT.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] I.YOKOYAMA: "Radioimmunoscintigraphy of human gastric carcinoma xenografts with ^<125>I-labled monoclonal antibody" Jpn.J.Cancer.Res.(Gann). 77. 1114-1121 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 村山 浩基: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断" 日外会誌. 90. 1732-1741 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 渡辺 正: "^<131>I標識抗CEAモノクローナル抗体の投与により診断しえた直腸癌局所再発I例" 日本大腸肛門病会誌. 42. 1272-1277 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 坂本 純一: "モノクローナル抗体を用いた大腸癌肝転移および局所再発に対する腫瘍画像診断" 日消外会誌. 23. 1001-1005 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 和田 喜美夫: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断-第2報:モノクローナル抗体CEA102のwhole lgGとF(ab')_2の比較" 日外会誌. 93. 266-273 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.SATOH: "Autoradiographic analysis of radiorabled anti-carcinoembrynic monoclonal antibody CEA102 colorectal cancer using computed radiography" Jpn.J.Cancer.Res.83. 379-386 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J.SAKAMOTO: "Detection of locally recurrent colorectal cancer with radiolabled monoclonal antibody H-15" Jpn.J.Cancer.Res.83. 1373-1381 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 村上 和之: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断-第3報:臨床症例20例の経験" 日外会誌. 94. 119-127 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 渡辺 正: "直腸肛門の外科・局所再発の対策と手術" 医学書院, 363 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] H.Murayama, T.Watanabe, M.Tadokoro, et al: "Radioimmunodetection of colorectal cancer using anti-CEA monoclonal antibodies" J.Jpn.Surg.Soc. 90. 1732-1741 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Watanabe, K.Murayama, K.Wada, et al: "Radioimmunodetection of a local recurrence of rectal carcinoma by 131I-labeled anticarcinoembryonic antigen monoclonal antibody CEA102" J.Jpn.Soc.Colo- proctol. 42. 1272-1277 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] K.Wada, T.Watanabe, M.Tadokoro, et al: "Radioimmunodetection of colorectal cancer using anti-CEA monoclonal antibody CEA102 ; whole IgG versus F(ab')2 fragments" J.Jpn.Sug.Soc. 93. 266-273 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] T.Satoh, T.Watanabe, M.Tadokoro, et al: "Autoradiographic analysis of radiolabeled antiCEA monoclonal antibody CEA102 in colorectal cancer using computed radiography" Jpn.J.Cancer Res. 83. 379-386 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J.Sakamoto, T.Kato, T.Watanabe, et al: "Detection of locally recurrent colorectal cancer with radiolabeled monoclonal antibody H-15" Jpn.J.Cancer Res. 83. 1373-1381 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] M.Murakami, T.Watanabe, T.Tadokoro, et al: "Radioimmunodetection of colorectal cancer, using anti-CEA monoclonal antibody CEA102 ; Experience of 20 cases" Jpn.J.Surg.Soc. 94. 119-127 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] J.Sakamoto: "Detection of locally recurrent colorectal cancer with radiolabled monoclonal antibody H-15" Jpn.J.Cancer.Res.83. 1373-1381 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 村上 和之: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断ー第3報:臨床症例20例の経験"

    • Related Report
      1992 Annual Research Report
  • [Publications] I.Yokoyama: "Radioimmunoscintigraphy of human gastric carcinoma xenografts with ^<125>I-labled monoclonal antibody" Jpn.J.Cancer.Res(Gann). 77. 1114-1121 (1986)

    • Related Report
      1992 Annual Research Report
  • [Publications] 村山 浩基: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断" 日外会誌. 90. 1732-1741 (1989)

    • Related Report
      1992 Annual Research Report
  • [Publications] 渡辺 正: "^<131>I標識抗モノクローナル抗体の投与により診断しえた直腸癌局所再発1例" 日本大腸肛門病会誌. 42. 1272-1277 (1989)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坂本 純一: "モノクローナル抗体を用いた大腸癌肝転移および局所再発に対する腫瘍画像診断" 日消外会誌. 23. 1001-1005 (1990)

    • Related Report
      1992 Annual Research Report
  • [Publications] 和田 喜美夫: "抗CEAモノクローナル抗体を用いた大腸癌の画像診断ー第2報:モノクローナル抗体CEA102のwhole IgGとF(ab')_2の比較" 日外会誌. 93. 266-273 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] T.Satoh: "Autoradiographic analysis of radiolabled anti-carinoembryonlc antigen monoclonal antibody CEA102 in colorectal cancer using computed radiography" Jpn.J.Cancer.Res.83. 379-386 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Tsuyoshi Sato: "Autoradiographic Analysis of radiolabeled anti CEA monoclonal antibody CEA102 in colorectal cancer using Computed Radiography" Jpn.J.Cancer Res.(Gann). (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 和田 喜美夫: "抗CEAモノクロ-ナル抗体を用いた大腸癌の画像診断ー第2報モノクロ-ナル抗体CEA102のwhole IgGとIgG F(ab')_2の比較" 日外会誌. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 村上 和之: "抗CEAモノクロ-ナル抗体を用いた大腸癌の画像診断ー第3報臨床例20例の経験" 日外会誌. (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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