| Project/Area Number |
03670615
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
SUZUKI Hiroshi Mie University, Faculty of Medicine, Professor, 医学部, 教授 (20004632)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Koichi Mie University, University Hospital, Assisutant Professor, 医学部附属病院, 講師 (80024694)
塚本 能英 三重大学, 医学部・附属病院, 助手 (30179981)
寺西 正 三重大学, 医学部, 助手 (60172102)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1993: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | Colorectal Cancer / Oncoprotein / Ki-67 Antibody / Immunohistochemikal Staining / 免疫組織化学染色 / Kiー67標識率 / 免疫組識化学染色 |
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| Research Abstract |
Ki-67 labeling index of 58 colorectal carcinomas and 10 normal mucosa samples was determined by the use of an immunohistochemical staining technique. The Ki-67 labeling index in colorectal carcinomas ranged from 15.7 to 63.3% (mean (〕SY.+-.〔) SD of 38.5 (〕SY.+-.〔) 10.5) and was significantly higher than the index for normal colon mucosa (mean (〕SY.+-.〔) SD of 14.1 (〕SY.+-.〔) 2.8). The mean Ki-67 labeling index was significantly higher in Dukes' B and Dukes' C tumors than in Dukes' A tumors, but the index did not correlate between the Ki-67 labeling index of the tumor and lymph node ivolvement. The present study disclosed that the Ki-67 labeling index correlated with local invasion of colorectal carcinoma, but not with metastasis of the tumor.
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