| Co-Investigator(Kenkyū-buntansha) |
IWAMOTO Takuya Kyushu University, Faculty of Medicine, Research Fellow, 医学部, 医員
HOTOKEZAKA Masayuki Kyushu University, Faculty of Medicine, Research Fellow, 医学部, 医員
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1991: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Research Abstract |
The effect of peptide YY (PYY) on the flow of splanchnic blood and bile was investigated in dogs. Under general anesthesia, the dogs received porcine PYY at a dose of 100, 400, or 800 pmol/kg/h for 1.5 hours. Before, during, and after PYY infusion, blood flow was measured in the subserosa of the jejunum, ileum, and colon as well as in the liver using the hydrogen gas clearance method. Choledochal bile was collected and its volume measured. Colonic blood flow was significantly inhibited by 100, 400, and 800 pmol/kg/h of PYY (p<0.05, p<0.05, and p<0.01, respectively). Jejunal blood flow was significantly decreased by 800 pmol/kg/h of PYY (p<0.01), while ileal blood flow was decreased only by 100 pmol/kg/h of PYY and not by lager doses (p<0.05). PYY did not change hepatic blood flow, but inhibited bile flow in a dose-dependent manner. These data demonstrate that PYY has an inhibitory effect on intestinal blood flow with variations in regional effect. PYY does not affect hepatic blood flow; its inhibitory effect on bile flow is therefore probably not the result of decreased hepatic perfusion.
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