| Project/Area Number |
03670637
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
HASHIMOTO Takashi Nagoya City University Medical School, assistant, 医学部, 助手 (10094393)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TANAKA Moritsugu Nagoya City University Medical School, assistant, 医学部, 助手 (10227184)
HANAI Takumi Nagoya City University Medical School, assistant, 医学部, 助手 (60164878)
|
|---|
| Project Period (FY) |
1991 – 1992
|
| Project Status |
Completed (Fiscal Year 1992)
|
| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
|
|---|
| Keywords | experimental liver cirrhosis / dimethyl nitrosamine / splenectomy / blood flow within the liver / 脾摘 / 肝血流 / 肝障害 / 免疫 / 動物実験 |
|---|
| Research Abstract |
This study describes the effect for the liver following splenectomy on the experimental liver cirrhosis using young rats. Sometimes splenectomy is performed for portal hypertention. But, we think it is not so good for the liver. In this study young rats with liver cirrhosis induced by dimethynitrosamine (1000ppm/100g, 3times/w, oral) were used. We found there rats certainly have liver cirrhosis for macroscopic and microscopic pathological findings. And normal rats and rats with sham operation used as controls.
The results obtained indicated that splenectomy for rats with liver cirrhosis increase temporary the flow of the liver just after operation, but decrease the flow of the liver for 4 weeks after splenectomy. And the rates of decrease the flow of the liver was related with the degree of liver damage. Otherwise, we could not find that splenectomy caused the reason of the liver disfunction and immunodisfunction for 4weeks after operation.
Then present observation suggest that splenectomy may disturb the liver regeneration, because splenectomy decrease the blood flow of the liver.
|
