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Antitumor effects of anitiandrogen on experimental esophageal carcinoma induced by N-Amyl-N-methlnitrosamine(AMN) in rats.

Research Project

Project/Area Number 03670642
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTokai University

Principal Investigator

KONDOH Yasumasa  Department of Surgery, School of Medicine, Tokai University Assistant Professor, 医学部, 講師 (00130063)

Co-Investigator(Kenkyū-buntansha) OGOSHI Kyoji  Department of Surgery, School of Medicine Tokai University Assistant Professor, 医学部, 講師 (30112775)
MAKUUCHI Hiroyasu  Department of Surgery, School of Medicine, Tokai University Associate Professor, 医学部, 助教授 (80095645)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsandrogen / flutamide / esophageal cancer / AMN / experimental esophageal cancer / 男性ホルモン
Research Abstract

It is well known that incidences of esophageal carcinoma in men are higher than those in women. Human skin is an androgen target organ and the androgen binding capacity of human skin cytosol was measured. We speculated that androgen might play an important role in carcinogenesis of the esophageal mucosa. Male 7-week-old rats of Sprague-Dawlew(SD) strain were used. AMN was dissolved in drinking water at a concentration of 0.003% and Flutamide(SCH13521 Shering Corporation), nonsteroidal antiandrogen agent, was administered as mixed into the solid diet in a daily dose of 20mg. The esophageal tissue were prepared to examine histopathologically. The incidences of carcinoma in intact and castrated rats administered AMN with Flutamide were significantly lower than those of intact rats administered AMN alone, and the incidences of carcinoma in intact and castrated rats that were given Flutamide after administration of AMN were significantly lower than that of intact rats were not given Flutamide after administration of AMN.These findings suggest that Flutamide has antitumor effects in experimental esophageal carcinoma induced by AMN in rats.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 近藤泰理: "抗アンドロゲン剤のN-Amyl-N-methylnitrosamine(AMN)ラット実験食道癌における治療効果について" 第50回日本癌学会総会記事. 55 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 近藤泰理: "抗アンドロゲン剤の食道癌治療応用に関するN-Amyl-N-methyl-nitrosamine(AMN)ラット発癌実験を用いた基礎的研究" 日本癌治療学会誌. 26. 1903 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasumasa Kondoh: "Antitumor effects of antiandrogen on experimental esophageal carcinoma induced by N-Amyl-N-methylnitrosamine(AMN) in rats." The Journal of Japan Society for Cancer Therapy.27. 379 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 近藤泰理: "N-Amyl-N-methylnitrosamine(AMN)誘発ラット実験食道癌における抗アンドロゲン剤の発癌抑制効果" 第51回日本癌学会総会記事. 65 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 近藤泰理: "非ステロイド性抗アンドロゲン剤FlutamideのAMN(N-Amyl-N-methylnitrosamine)ラット実験食道癌における発癌抑制について" 第52回日本癌学会総会記事. 22 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yasumasa Kondoh, Kyoji Ogoshi, Hiroyasu Makuuchi, Tomoo Tajima and Toshio Mitomi: "Antitumor effets of antiandrogen on experimental esophageal carcinoma induced by N-Amyl-N-methl-nitrosamine(AMN) in rats." The Journal of Japan Society for Cancer Therapy.Vol.27, No.2. 379 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 近藤泰理: "非ステロイド性抗アンドロゲン剤FlutamideのAMN(N-Amy1-N-methylnitrosamine)ラット実験食道癌における発癌抑制について" 第52回日本癌学会総会記事. 22 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 近藤 泰理: "N-Auryl-N-wethyluitrosamine(AMN)誘発ラット実験食道癌における抗アンドロゲン剤の発癌抑制効果" 日本癌学会総会記事. 51. 65- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 近藤 泰理,上條 あけみ,生越 喬二,幕内 博康,田島 知郎,三富 利夫: "抗アレドロゲン剤のNーAmylーNーmethylnitrosamine(AMN)ラット実験 食道癌における治療効果について" 日本癌学会総会記事. 50. 55 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 近藤 泰理,生越 喬二,幕内 博康,田島 知郎,三富 利夫: "抗アンドロゲン剤の食道癌治療応用に関するNーAmylーNーmethylーmtrosamine(AMN)ラット発癌実験を用いた基礎的研究" 日本癌治療学会誌. 26. 1903 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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