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Microcirculatory disturbances in cerebral ischemia; Analysis of pathophysiology and therapeutic approach

Research Project

Project/Area Number 03670683
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionOsaka University

Principal Investigator

YOSHIMINE Toshiki  Osaka Univ., Med. School, Assistant, 医学部, 助手 (00201046)

Co-Investigator(Kenkyū-buntansha) KATO Amami  Osaka Univ., Med. School, Assistant, 医学部, 助手 (00233776)
HAYAKAWA Toru  Osaka Univ., Med. School, Professor, 医学部, 教授 (20135700)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordscerebral ischemia / microcirculation / superoxide / SOD / 赤血球 / 白血球 / 血小板
Research Abstract

1. Pathologic process of microcirculatory disturbance in focal cerebral ischemia.
Our previous study demonstrated that the length of plasma-per fused microvessels decreased in the ischemic foci during the several hours of rat focal cerebral ischemia. The aim of the present investigation is to elucidate the mechanism of this microcirculatory disturbance.
2. Effect of superoxide dismutase (SOD).
When SOD was administered continuously during the several hours of acute focal cerebral ischemia, the microvascular patency was significantly preserved. Those data suggests that the formation superoxide during the acute stage of cerebral ischemia may cause endothelial injury and facilitate intravascular clot formation. The application of SOD also decreased the size of histologically noticeable damage.
3. Protection of ischemic brain damage via preservation of microcirculation.
The present study demonstrated SOD could be a useful agent to protect the brain against ischemia. Although SOD has been expected to reduce tissue damage directly by eliminating free radicals that cause tissue injury, the present study suggested preservation of microcirculation by SOD may also contribute to protect brain injury against cerebral ischemia. Since recombinant human SOD is available for clinical trial for cardiac attacks, the use of this agent against cerebral ischemia is also expected.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] 吉峰 俊樹: "脳循環の特異性" 循環制御. 12. 195-201 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳虚血による微小循環障害と細胞傷害の発生" 日本救急医学会雑誌. 2. 233-234 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳虚血と神経細胞障害" Brain Medical. 4. 101-106 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YAMAMOTO,S: "Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayd neuronal death in gerbils." Neuroscience Letters. 141. 161-165 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "神経成長因子(nerve growth factor)による虚血性神経細胞死の防止" 神経病理学. 11. 135-139 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "神経移植とFGF" Clinical Neuroscience. 10. 1019-1022 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 竹本 理: "小動物における脳虚血モデル" 病態生理. 11. 696-702 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳虚血急性期の微小循環障害。微小血管内血栓およびラジカル産生の関与。" Therapeutic Research. 13. 3261-3269 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中島 伸: "実験的脳虚血急性期の微小循環障害に対する組織プラスミノゲン活性化因子の効果。" 脳卒中. 14. 613-618 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳虚血・再灌流と微小循環障害" nanoGIGA. (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "虚血と臓器障害-虚血によって何が起こるか?" へるす出版, 141 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "The characteristics of cerebral circulation" Circulation Regulation. 12. 195-201 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "The development of microcircuratory disturbance and tissue damage in cerebral ischemia" Jap J Acute Med. 2. 233-234 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "Ischemic organ damage. What happens by tissue ischemia?" Health Publishing Co. td. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "Cerebral ischemia and neuronal damage" Brain Medical. 4. 101-106 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamamoto S: "Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayed neuronal death in gerbils" Neurosci Lett. 141. 161-165 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yishimine T: "Protection of ischemic neuronal death by nerve growth factor" Neuropathol. 11. 135-139 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "Nerve transplantation and FGF" Clinical Neurosci. 10. 1019-1022 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Takemoto O: "Cerebral ischemia models in small animals" Pathophysiology. 11. 696-702 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "Microcirculatory disturbance in the acute syage of cerebral ischemia" Therapeutic Res. 13. 3261-3269 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakajima S: "Effect of tissue-type plasminogen activator on the microcirculatory distuebance in experimental acure cerebral ischemia" Jap J Stroke. 14. 613-618 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yoshimine T: "Microcirculatory disturbance in cerebral ischemia/reperfusion" nanGIGA. (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 吉峰 俊樹: "脳循環の特異性" 循環制御. 12. 195-201 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血による微小循環障害と細胞傷害の発生" 日本救急医学会雑誌. 2. 233-234 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血と神経細胞障害" Brain Medical. 4. 101-106 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamamoto,S: "Protective effect of NGF atelocollagen mini-pellet on the hippocampal delayed neuronal death in gerbils." Neuroscuence Letters. 141. 161-165 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "神経成長因子(nerve growth factor)による虚血性神経細胞死の防止" 神経病理学. 11. 135-139 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "神経移植とFGF" Clinical Neuroscience. 10. 1019-1022 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 竹本 理: "小動物における脳虚血モデル" 病態生理. 11. 696-702 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血急性期の微小循環障害。微小血管内血栓およびラジカル産生の関与。" Therapeutic Research. 13. 3261-3269 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中島 伸: "実験的脳虚血急性期の微小循環障害に対する組織ブラスミノゲン活性化因子の効果。" 脳卒中. 14. 613-618 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血・再潅流と微小循環障害" nanoGIGA. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "虚血と臓器障害-虚血によって何が起こるか?" へるす出版, 141 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳循環の特異性" 循環制御. 12. 195-201 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血による微小循環障害と細胞障害の発生" 日本救急医学雑誌. 2. 233-234 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉峰 俊樹: "虚血性神経細胞死" Brain Medical. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉峰 俊樹: "神経成長因子(nerve growth factor)による虚血性神経細胞死の防止" 神経病理. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉峰 俊樹: "脳虚血急性期の微小循環障害ー微小血管内血栓形成およびラジカル産生の関与" Therapeutic Research. 13. (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] 吉峰 俊樹: "虚血と臓器障害(宮崎正夫編)" ヘルス出版, 142 (1991)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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