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Intrinsic control of cerobro-vascular tone-role of central nor-advenergic system

Research Project

Project/Area Number 03670690
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionJuntendo University School of Medicine

Principal Investigator

MAEDA Minoru  Juntendo University, Dept. of Neurosurgery, Professor, 医学部, 教授 (40101430)

Co-Investigator(Kenkyū-buntansha) MORI Kentarou  Juntendo University, Dept. of Neurosurgery, Assistant Professor, 医学部, 講師 (30200364)
Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsCerebro-vascular tone / Central nor-adrenergic system / Locus Coeruleus Complex / Medullary Reticular Formation / Cholinoceptive Pontine Area / Plateau Wave / Increased ICP / 中枢性ノル・アドレナリン系 / 頭蓋内圧・圧波 / 脳腫脹 / 視床下部・中脳 / 脳幹網様体
Research Abstract

We have investigated the role of the central dorsal and rentral noradrenergic systems (Locus Coeruleus Complex, LC, Medullary Reticular Formation, MRF) and the cholinoceptive pontine area (CPA) in control of cerebral vasomotor tone. The experiments were performed on 30 chloralose-anesthetized cats with or without Kaolin induced hydrocephalus.
[I] Microinjection of glutamate or carbochol into the LC or the MRF induced decrease of ICP in association with a slight rise of BP.On the other hand microinjection of carbachol or Ach into the CPA produced "plateau wave" like ICP-variations.
[II] Tonic discharges of the LC neuron were gradually suppressed at 10 to 30 sec. prior to the onset of plateau waves, almost completely silenced during the plateau phase. Tonic MRF-neuron discharges were gradually suppressed about 30 sec. before onset o fplateau wave like ICP-variations and sharply suppressed during the plateau phase. Recovery began 10 to 30 sec. before the ICP decrease. On the other hand, the firing rate of the CPA-neuron was increased in phase with the plateau waves.
[III] Electrophysiological studies show that the CPA neurons suppress both the LC and MRF-neurons which make up the central noradrenergic system. Activation of the CPA neurons should suppress activity in the central noradrenergic system. The increase in CBV then occurrs in response to dilatation of cerebral vessels.
These results suggest that activity within the CPA, LC and MRF contributes to ICP changes and is the endogenous neuronal origin of plateau waves occurring in some conditions such as Kaolin induced hydrocephalus.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 前田 稔: "頭蓋内圧亢進と脳虚血" 循環制御. 12. 229-237 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Yabuki,H.Mishina and M.Maeda: "AVDO_2 and EEG as Indicators for Treatment of Post-traumatic Brain Swelling" Neurologia medico-chirurgica. 31. 568-574 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Maeda,M.Miyazaki and S.Ishii: "Control of ICP by The Medullary Reticular Formation" Intracranial Pressure. 8. 207-213 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] K.Mori,K.Nakajima and M.Maeda: "Theoretical and Experimental Assessment of the Kinetic Properties of N-isopropyl-P-〔^<123>I〕iodoamphetamine in the Human Brain" Neurologia medico-chirurgica. 33. 809-814 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 前田 稔、中島 啓次、酒井 保男、鈴木 茂樹: "頭蓋内圧力環境を知る新しい指標としてのヒステリシス面積率の検討" Progress in Research on ICP. 4. 13-19 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] B-Nan,XU,A.Yabuki,H.Mishina,M.Maeda: "Pathophysiology of Brain Swelling after Acute Experimental Brain Compression and Decompression" Neurosurgery. 32. 289-296 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Maeda.M: "The Head-Neck Sensory Motor Systems" Oxford University Press, 748 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Maeda.M,Miyazaki.M and Ishi.S: "Intracranial Pressure VIII" Springer-Verlag, 931 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] A.Yabuki, H.Mishina, M.Maeda: "AVDO_2 and EEG as indicators for Treatment of Post-Traumatic Brain Swelling" Neurologia medico-chirurgica. 31. 568-574 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Maeda, K.Nakajima, Y.Sasaki, S.Suzuki: "Analysis of a guantitative hysteresis area rate as an indicator for pathologicdal changes in intracranial components" Progrers in Research on ICP. 4. 13-19 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Maeda, M.Miyazaki, S.Ishi: "Control of ICP by Medullary Reticular Formation" Intracranial Pressure. 8. 207-213 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] B-N.Zu, A.Yabuki, H.Mishina, M.Maeda: "Pathophysiology of Brain Swelling after Acute Experimental Brain Compression and Decompression" Neurosurgery. 32. 289-296 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] M.Maeda,S.Ishi: "Control of ICP by the Medullary Reticular Formation" Intracranial pressure. 8. 207-213 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 前田 稔、中島 啓次: "頭蓋内圧力環境を知る新しい指標としてのヒステリシス面積率の検討" Progress in Research on ICP. 4. 13-19 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Bai-Nan Xu,Minoru.maeda: "Pathophysiology of Brain Swelling after Acute Experimental Brain Compression and Decompression" Neurosurgery. 32. 289-296 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 前田 稔: "脳血管床の調節機構と頭蓋内圧力環境" 局所脳血流懇話会誌. 24. 32-55 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] K.Mori,M.Maeda: "Theoretical and Experimental Assessment of the Kinetic Properties of ^<123>I-amphetamine in the Human Brain" Neurologia Medico chirurgica. 33. 809-814 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Maeda.M: "The Head-Neck Sensory Motor Systems" Oxford University Press, 748 (1992)

    • Related Report
      1993 Annual Research Report
  • [Publications] Maeda.M: "Intracanial Pressure VIII" Springer-Verlag, 931 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] 前田 稔,宮崎 正弘,石井 昌三: "頭蓋内圧の制御における延髄網様体の関与について" Neurologia medico-chirurgica. 76- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maeda,M.Miyazaki,M and Ishii: "Control of ICP by The Medullary Reticular Formation" Intracranial Pressure. 8. (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 森 健太郎、中島 啓次、前田 稔: "N-isopropyl-p-[^<123>I]Iodoamphetamine(IMP)の脳内動態の理論的実験的検討について" 脳循環代謝. 4. 77- (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maeda M: "The Head-Neck Sensory Motor System" Oxford University Press, 748 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Maeda,M.Miyazaki,M.,and Ishii,S: "Intracranial Pressure 8" Springer-Verlag, (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 前田 稔: "頭蓋内圧力環境の制御における脳幹の役割" Neurosurgeons. 10. 274-285 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 前田 稔: "頭蓋内圧亢進と脳虚血" 循環制御. 12. 229-237 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Maeda,M.,Miyazaki,M.,and Ishii,S.: "Control of ICP by The Medullary Reticular Formation" Intracranial Pressure. 8. 15 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yabuki,A.,Maeda,M.,Sato,K.,and Ishii,S.: "AVDO_2 and EEG as Indicators for Treatment of Postーtraumatic Brain Swelling." Neurologia medicoーchirurgica. 31. 568-574 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Maeda,M.,Miyazaki,M.and Ishii,S.: "Intracranial Pressure VIII" SpringerーVerlag, (1992)

    • Related Report
      1991 Annual Research Report
  • [Publications] Yabuki,A.,Mishina,H.and Maeda,M.: "Intracranial Pressure VIII" SpringerーVerlag, (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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