| Project/Area Number |
03670690
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Juntendo University School of Medicine |
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Principal Investigator |
MAEDA Minoru Juntendo University, Dept. of Neurosurgery, Professor, 医学部, 教授 (40101430)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Kentarou Juntendo University, Dept. of Neurosurgery, Assistant Professor, 医学部, 講師 (30200364)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Cerebro-vascular tone / Central nor-adrenergic system / Locus Coeruleus Complex / Medullary Reticular Formation / Cholinoceptive Pontine Area / Plateau Wave / Increased ICP / 中枢性ノル・アドレナリン系 / 頭蓋内圧・圧波 / 脳腫脹 / 視床下部・中脳 / 脳幹網様体 |
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| Research Abstract |
We have investigated the role of the central dorsal and rentral noradrenergic systems (Locus Coeruleus Complex, LC, Medullary Reticular Formation, MRF) and the cholinoceptive pontine area (CPA) in control of cerebral vasomotor tone. The experiments were performed on 30 chloralose-anesthetized cats with or without Kaolin induced hydrocephalus.
[I] Microinjection of glutamate or carbochol into the LC or the MRF induced decrease of ICP in association with a slight rise of BP.On the other hand microinjection of carbachol or Ach into the CPA produced "plateau wave" like ICP-variations.
[II] Tonic discharges of the LC neuron were gradually suppressed at 10 to 30 sec. prior to the onset of plateau waves, almost completely silenced during the plateau phase. Tonic MRF-neuron discharges were gradually suppressed about 30 sec. before onset o fplateau wave like ICP-variations and sharply suppressed during the plateau phase. Recovery began 10 to 30 sec. before the ICP decrease. On the other hand, the firing rate of the CPA-neuron was increased in phase with the plateau waves.
[III] Electrophysiological studies show that the CPA neurons suppress both the LC and MRF-neurons which make up the central noradrenergic system. Activation of the CPA neurons should suppress activity in the central noradrenergic system. The increase in CBV then occurrs in response to dilatation of cerebral vessels.
These results suggest that activity within the CPA, LC and MRF contributes to ICP changes and is the endogenous neuronal origin of plateau waves occurring in some conditions such as Kaolin induced hydrocephalus.
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