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The Induction of the Heat Shock Protein under the Hypoxic Condition

Research Project

Project/Area Number 03670721
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

ITO Yusuke  Medicine,Anaesthesiology, Professor, 医学部, 教授 (70018307)

Co-Investigator(Kenkyū-buntansha) MASUDA Toru  Medicine,Anaesthesiology, research associate, 医学部, 助手 (20173750)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1992: ¥200,000 (Direct Cost: ¥200,000)
Fiscal Year 1991: ¥2,100,000 (Direct Cost: ¥2,100,000)
KeywordsHYPOXIA / HEAT SHOCK PROTEIN / 熱ショック蛋白質
Research Abstract

It is known that heat shock protein (HSP) is induced responding to various stresses not only a heat shock which is the origin of a name of this protein. One of inducible stresses is the ischemic condition. In this study we investigate the locality of HSP induction under the low oxygen condition using a hypoxic model of 5 % oxygen inhalation that we have used since before in this research and 2 min anoxia model suspending the ventilator. Additionally, we persuaded the fluctuation of HSP induction quantitatively by the method of immunoblotting technique. In the ischemic model of gerbil the HSP was induced strongly in our experiment as well as previously reported. On the other hand, the induction of HSP was slight in the rat hypoxic model and even in the rat ischemic model. Two reasons are conceivable to this result. There are some reports since before that rat is a comparatively strong animal species in the low oxygen condition. Therefore,HSP induction was small in hypoxic rat's brain. A … More nother reason is that our experiment model of low oxygen condition accompanies a decrease of the heart rate unlike a brain ischemic model. Therefore an influence is exerted on a whole body. The incomplete ischemic condition like this becomes a fatal blow for a digestive organ system particularly the small intestine. Acker et al reported that in the case of a decreased blood flow a blood flow circulates to a brain and a heart preferentially. Therefore,these organs were protected in the incomplete ischemia. When an extent of a hypoxic load is strong,the induction of HSP increased. It peaked in a day or two. The phenomenon of ischemic tolerance well known if it gets weak ischemia done before severe ischemia is suffered. We tried to apply the 2nd load in a day after a mild hypoxic event. Surely the HSP was induced, but the injury was accumulative rather than the acquisition of tolerance. Although congestion and bleeding were seen at the small intestine and the cecum,there was not a change especially in a nerve cell of the nerve terminals which distributes to intestines even in such a case. The acquisition of ischemic tolerance by the HSP may limit to a nerve cell only. Less

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] HIROTA K,ITO Y,KUZE S,and Momose Y: "Effects of halothane on electrophysiologic properties and cycle adenosine 3',5'-monophosphate content in isolated guinea pig hearts." Anesth.Analg.74. 564 569 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YAMAZAKI M,MASUDA T,ITO Y,KUZE S,and MOMOSE Y: "Changes in rat striatum catecholamine during hypoxia with reference to protective effects of flunarizine." Pharmacol.Toxicol.70. 294 298 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] YAMAZAKI M,ITO Y,KUZE S,SHIBUYA N,and MOMOSE Y: "Effects of ketamine on voltage-dependent Ca2+ currents in single smooth muscle from rabbit portal vein." Pharmacol.45. 162 169 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KUZE S,NARUSE T,YAMAZAKI M,HIROTA K,ITO Y,and MIYAHARA T: "Effects of sodium L-Lactate and sodium racemic lactate on intraoperative acid-base status." Anesth.Analg.75. 702 707 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 久世 照五,藤村 純子,浜田 富美男,成瀬 隆倫,岩瀬 久美,釈永 清志,窪 秀之,畠山 登,増田 達,広田 弘毅,桐山 昌子,山崎 光章,増田 明,伊藤 祐輔,渋谷 伸子,佐藤 根敏彦,小泉 保: "薬物動態から見た乳酸代謝" 臨床麻酔. 16. 873-879 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 久世 照五,畠山 登,伊藤 裕輔,中丸 勝人,奥野 政一,佐藤 根敏彦,林 隆一: "本院における手術申し込みシステムとその活用「麻酔・集中治療とテクノロジー1992」盛生倫夫、風間富栄、池田和之、尾山力 編" 克誠堂出版 、東京, 5 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirota K., Ito Y., Kuze S., and Momose Y.: "Effects of halothane on electrophysiologic properties and cyclic adenosine 3', 5'- monophosphate content in isolated guinea pig hearts." Anesth. Analg.74. 564-569 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamazaki M., Masuda T., Ito Y., Kuze S., and Momose Y.: "Changes in rat striatum catecholamine during hypoxia with reference to protective effects of flunarizine." Pharmacol. Toxicol.70. 294-298 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamazaki M., Ito Y., Kuze S., Shibuya N., and Momose Y.: "Effects of ketamine on voltage-dependent Ca2+ currents in single smooth muscle cells from rabbit portal vein." Pharmacol.45. 162-169 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kuze S., Naruse T., Yamazaki M., Hirota K. Ito Y., and Miyahara T.: "Effects of sodium L-Lactate and sodium racemic lactate on intraoperative acid-base status." Anesth. Analg.75. 702-707 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hirota K.,Ito Y.,Kuze S.,and Momose Y.:"Effects of halothane on electrophysiologic properties and cyclic adenosine 3',5'-monophosphate content in isolated guinea pig hearts." Anesth.Analg.74. 564-569 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamazaki M.,Masuda T.,Ito Y.Kuze S.,and Momose Y.:"Changes in rat striatum catecholamine during hypoxia with reference to protective effects of flunarizine." Pharmacol.Toxicol.70. 294-298 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Yamazaki M.,Ito Y.,Kuze S.,Shibuya N.,and Mmose Y.:"Effects of ketamine on voltage-dependent Ca^<2+> currents in single smooth muscle cells from rabbit portal vein." Pharmacol.45. 162-169 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kuze S.,Naruse T.,Yamazaki M.Hirota K.Ito Y.,and Miyahara T.: "Effects of sodium L-Lactate and sodium racemic lactate on intraoperative acid-base status." Anesth.Analg. 75. 702-707 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 久世 照五、藤村 純子、浜田 富美男、成瀬 隆倫、岩瀬 久美、釈永 清志、窪 秀之、畠山 登、増田 達、広田 弘毅、桐山 昌子、山崎 光章、増田 明、伊藤 祐輔、渋谷 伸子、佐藤根 敏彦、小泉 保: "薬物動態から見た乳酸代謝." 臨床麻酔. 16. 873-879 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 久世 照五、畠山 登、伊藤 祐輔、中丸 勝人、奥野 政一、佐藤根 敏彦、林 隆一: "本院におれる手術申込システムとその活用「麻酔・集中治療とテクノロジー1992」盛生倫夫、風間富栄、池田和之、尾山力編" 克誠堂出版、東京, 5 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 増田 達,伊藤 祐輔: "低酸素負荷時の、遊離脂肪酸の放出と形態学的変化" 日本麻酔、薬理学会誌. 第4巻. 29-30 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] M.Yamazaki T.Masuda S.Kuze Y.Ito: "Changes in the Rat Striatum Catecholamine during Hypoxic Hypoxia with Reference to Protective Effect of Flunarizine" Pharmacology and Toxicology.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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