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Study of vasoconstrictire protein in renal artery

Research Project

Project/Area Number 03670744
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionYamagata University

Principal Investigator

NAKADA Teruhiro  Yamagata University Sch of Med, Professor, 医学部, 教授 (50009495)

Co-Investigator(Kenkyū-buntansha) ISHIGOOKA Manabu  Yamagata University Sch of Med, Assistant, 医学部, 助手 (20202989)
山口 寿功  山形大学, 医学部, 助手 (70230365)
川村 俊三  山形大学, 医学部, 助教授
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsSHR, SHRSP / non-collagen protein / collagen / renovascular hypertension / phenoxybenzamine / hypertension / norepinephrine / neural factor / pnenoxybenzamine / 非コラ-ジェン蛋白質 / コラ-ジェン / エラスチン / 高血圧症 / 腎動脈
Research Abstract

Synthesis of vascular protein was investigated in renal arteries of stroke-prone and-resistant spontaneously hypertensive rats (SHR, SHRSP). The effect of POB and surgical or pharmacological denervation of the root of the renal and/or mesenteric arteries prevented the development of hypertension of these animals. Incorporation of tritiated proline into the vessels described above were also decreased following the antihypertensive treatments. Positive correlations of ^3H-proline incorporation into the renal or mesenteric artery and systolic blood pressure were remarkably noted.
However, in chronic hypertensive stages, these relationship were not observed.
Based on these findings, vasoconstractive protein, especially non-collagenous protein and collagen appear to possess a vasoconstractive capability. These connective tissue protein was probably mediated neural factors.
In clinical patients, contents of non-collagenous protein and collagen revealed to be high in hypertensive patients.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] YAMAGUCHI,T. & NAKADA,T.: "Catecholamine metabolism in the vas deferense and the adrenal gland with special reference to central catecholamine depleted status." Experientia. 48. 667-671 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] NAKADA,T.,SASAGAWA,I.,YAMAGUCHI,T., et al.: "Xanthofibroma of the adrenal gland." Internat.Urol.Nephrol.24. 337-343 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KANEKO,H. and NAKADA,T.: "Central catecholamine,sympathetic nerve and vascular protein in the acute phase of two-kidney,one clip renovascular hypertension." Internat.Urol.Nephrol.24. 531-540 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] WATANABE,M.,NAKADA,T. et al.: "Crossed ectopia of left vas deferens,leaving ipsilaterral seminal vesicle in normal position." J.Urol.148. 886-888 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 金子 尚嗣、中田 瑛浩: "ラットの2腎性腎血管性高血圧症の急性期における交感神経および血管蛋白質に関する研究" 腎移植血管外科. 3. 154-158 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中田 瑛浩、小池 宏: "リドル症候群" ホルモンと臨床. 3. 154-158 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中田 瑛浩: "内分秘外科・標準手術アトラス" インターメルク社, 252 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 中田 瑛浩: "血管収縮蛋白質と高血圧症" 第37回平成2年度社会事業助成研究報告書, 2 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamaguchi,T. and Nakada,T.: "Catecholamine metabolism in the vas deferens and the adrenal gland with special reference to central catecholamine depleted status." Experientia. 48. 667671 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakada,T. and Sasagawa,I.: "Xanthofibroma of the adrenal gland." Internat.Urol.Nephrol.24. 337-343 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaneko,H. and Nakada,T.: "Central catecholamine, sympathetic nerve and vascuprotein the acute phase of two-kidney, one clip renovascular hypertension." Internat.Urol.Nephrol.24. 531-540 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Watanabe,H., Nakada,T.et al.:"Crossed ectopia of left vas deferens, leaving ipsilateral seminal vesicle in normal position." J.Urol.148. 886-888 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Kaneko,H. and Nakada,T.: "Study of neural factor and vascular protein in acute phase of renovascular hypertension. (in Japanese)." Renal Transplantation and Vascular Surgery. 3. 154-158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakada,T.et al.: "Liddle's syndrome. (in Japanese)" Hormone and Clinics. 3. 154-158 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakada,T. et al.: "Adrenal Surgery (in Japanese)" Atlas of Endocrine Surgery. (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nakada,T.: "Vasoconstrictive protein and Hypertension (in Japanese)" 37th Shakaijigyo Kenkyu Jyosei.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Yamaguchi,T. & Nakada,T.: "Catecholamine metabolism in the vas deferense and the adrenal galnd with special reference to contral catecholamine depleted status." Experientia. 48. 667-671 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Nakada,T.,Sasagawa I.,Yamaguchi,T., et al.: "Xanthofibroma of the adrenal gland." Internat.Urol.Nephrol.24. 337-343 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kaneko,H. and Nakada,T.: "Central catecholamine,sympathetic nerve and vascular protein in the acute phase of two-kidney,one clip renovascular hypertension." Internat.Urol.Nephrol.24. 531-540 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Watanabe,M.,Nakada,T. et al.: "Crossed ectopia of left vas deferens,leaving ipsilateral seminal vesicle in normal position." J.Urol.148. 886-888 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 中田瑛浩: "血管収縮蛋白質と高血圧" インターメルク社, 2 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Kaneko,H.and Nakada,T.: "Central catecholamine,vascular protein and renin of acute phrase in twoーkindney,one clip renovascular hypertention." Internat.Urol.Nephrol.3. 154-158 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 金子 尚嗣,中田 瑛浩: "ラットの2腎性腎血管性高血圧症の急性期における交感神経および血管蛋白質に関する研究" 腎移植血管外科. 3. 154-158 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 中田 瑛浩,川村 俊三: "腎血管性高血圧症" 腎と透析. 29. 244-246 (1990)

    • Related Report
      1991 Annual Research Report
  • [Publications] Nakada,T.: "Ageーrelated differences in norepinephrine and nonーcollagenous protein in human vas deferens." Urology/Nephrology. 4. 20-21 (1990)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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