| Project/Area Number |
03670772
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tokyo |
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Principal Investigator |
MITSUHASHI Naoki FACULTY OF MEDICINE,UNIVERSITY OF TOKYO LECTURER, 医学部(病), 講師 (60114667)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | ESTROGEN RECEPTOR / PROGESTERONE RECEPTOR / ANDROGEN RECEPTOR / LONG CHAIN FATTY ACID / ARACHIDONIC ACID / DOCOSAHEXAENOIC ACID / PHOSPHOLIPID / PHOSPHATIDYL INOSITOL / フォスファチジルイノシトール / エストロゲンレセプタ- / プロゲスチンレセプタ- / 脂肪酸 |
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| Research Abstract |
Estrogen and progesterone receptors were obtained from rat uterus. Androgen receptor was obtained from rat prostate gland. The binding between progesterone receptor and R-5020 was inhibited by long chain unsaturated fatty acids,such as arachidonic acid or docosahexaenoic acid. This inhibitory effect was dose dependent. Estrogen receptor was also inhibited by long chain unsaturated fatty acids. Androgen receptor was also inhibited by long chain unsaturated fatty acids. However, saturated fatty acids had no effect on the steroid hormone receptors. Moreover, these inhibitory effects of long chain unsaturated fatty acids was not competitive one.
The effects of phospholipids on the steroid hormone receptors were investigated. Phosphatidyl inositol and phosphatidyl serine inhibited the binding between progesterone receptor and R-5020. On the estrogen receptor, phosphatidyl inositol, phosphatidyl serine, phospatidyl ethanol amine had inhibitory effect. Such inhibitory effect was dose dependent.
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