| Project/Area Number |
03670775
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE |
|---|
Principal Investigator |
KANAYAMA Naohiro HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部, 助手 (70204550)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUMIMOTO Kazuhiro 浜松医科大学, 医学部, 助手 (30126817)
|
|---|
| Project Period (FY) |
1991 – 1993
|
| Project Status |
Completed (Fiscal Year 1993)
|
| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
|
|---|
| Keywords | Zn-Coproporphyrin / Amniotic Fluid Embolism / Fluorometry / HPLC / 羊水 / 亜鉛コプロポルフィリン / 羊水塞栓症 / ショック / HPLC. |
|---|
| Research Abstract |
We measured the concentration of zinc coproporphyrin I (ZnCP-I), a characteristic component of meconium, in maternal plasma by fluorometry after HPLC.We obtained plasma samples from 89 women : 35 at weeks 10-40 of normal pregnancy, 41 shortly after normal delivery, 4 from patients with amniotic fluid embolism (AFE), and 9 from non-AFE patients with intra- or postpartum shock caused by genital bleeding. The plasma ZnCP-I concentration was 97 (SD 83, range 38-240) nmol/L in the AFE patients, 11 (SD 9.2) nmol/L in the non-AFE patients, 12 (SD 7.9) nmol/L during normal pregnancy, and 26 (SD 10) nmol/L shortly after normal delivery. We suggest that measuring ZnCP-I in maternal plasma by fluorometry on HPLC is a rapid, noninvasive, and sensitive method for diagnosing AFE and propose 35 nmol/L as the cutoff value for the ZnCP-I concentration in maternal plasma for the diagnosis of AFE.
|
