Analysis of Ag-Ab reaction in HTLV-I mother to child infection

Research Project

Project/Area Number	03670797
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Obstetrics and gynecology
Research Institution	Wakayama Medical College, Kihoku Branch (1993) Nara Medical University (1991-1992)
Principal Investigator	ANDO Yoshiya 和歌山県立医科大学, 紀北分院・産婦人科, 教授 (90145855)
Project Period (FY)	1991 – 1993
Project Status	Completed (Fiscal Year 1993)
Budget Amount *help	¥2,100,000 (Direct Cost: ¥2,100,000) Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000) Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000) Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
Keywords	HTLV-I / Infection / Synthetic peptide / HTLV-I Antibody / 合成peptide / HTLV-I antibody / XC assay
Research Abstract	I examined the function of the antibody fruction for HTLV-I.Antibody for HTLV-I env gp46^<175-199> and gp46^<242-257>, neutralize the infectivity from HTLV-I bearing cell line cells to normal peripheral blood lymphocytes in vitro, but not effect the HTLV-I antigen expression from HTLV-I carrier's PBL in culture. In contrast, antibody for HTLV-I gag p19^<100-130> diminishes the HTLV-I antigen expression from HTLV-I carrier's PBL, but not recognized the neutralizing function in vitro. So, protective effect on HTLV-I infection persisted in the antibody for the env and gag, especially antibody for gag, functionated to supression of HTLV-I related protein production.