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Analysis of Ag-Ab reaction in HTLV-I mother to child infection

Research Project

Project/Area Number 03670797
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionWakayama Medical College, Kihoku Branch (1993)
Nara Medical University (1991-1992)

Principal Investigator

ANDO Yoshiya  和歌山県立医科大学, 紀北分院・産婦人科, 教授 (90145855)

Project Period (FY) 1991 – 1993
Project Status Completed (Fiscal Year 1993)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1993: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1992: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1991: ¥700,000 (Direct Cost: ¥700,000)
KeywordsHTLV-I / Infection / Synthetic peptide / HTLV-I Antibody / 合成peptide / HTLV-I antibody / XC assay
Research Abstract

I examined the function of the antibody fruction for HTLV-I.Antibody for HTLV-I env gp46^<175-199> and gp46^<242-257>, neutralize the infectivity from HTLV-I bearing cell line cells to normal peripheral blood lymphocytes in vitro, but not effect the HTLV-I antigen expression from HTLV-I carrier's PBL in culture. In contrast, antibody for HTLV-I gag p19^<100-130> diminishes the HTLV-I antigen expression from HTLV-I carrier's PBL, but not recognized the neutralizing function in vitro.
So, protective effect on HTLV-I infection persisted in the antibody for the env and gag, especially antibody for gag, functionated to supression of HTLV-I related protein production.

Report

(4 results)
  • 1993 Annual Research Report   Final Research Report Summary
  • 1992 Annual Research Report
  • 1991 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yoshiya Ando,Takuo Takigawa,Yutaka Ekuni et.al: "Family study of woman showing development of antibody to human T-cell leukemia virus I and assessment of the risk of vertical transmission of the virus to their children" Journal of Infection. 27. 151-155 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] 安藤良弥.一條元彦: "HTLV-Iの母児感染対策" 病理と臨床. 11. 352-358 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1993 Final Research Report Summary
  • [Publications] Yoshiya Ando: "Family study of women showing development of antibody to human T-cell leukemia virus I and assessment of the risk of vertical transmission" Journal of Infection. 27. 151-155 (1993)

    • Related Report
      1993 Annual Research Report
  • [Publications] Yoshiya Ando et al.: "FAMILY STUDY OF ADULT FEMALES SHOWING COVERSION TO HTLV-I ANTIBODY POSITIVITY AND ASSESMENT OF THE RISK OF VERTICAL HTLV-I TRANSMISSION TO THEIR CHILDREN" The Journal of Infection. (1993)

    • Related Report
      1992 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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