• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

A STUDY OF THE NEW INHIBITORY DRUG FOR BONE RESORPTION, BISPHOSPHONATES, ON THE ALVEOLAR BONE RESORPTION PROCESS.

Research Project

Project/Area Number 03670863
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

OHYA Keiichi  TOKYO MEDICAL AND DENTAL UNIVERSITY FACULTY OF DENTISTRY ASSOCIATE PROFESSOR, 歯学部, 助教授 (10126211)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsBONE RESORPTION / LOW Ca DIET / BISPHOSPHONATE / ALVEOLAR BONE / OSTEOCLAST / ANTI-BONE RESORBING DRUG / bisphosphonate
Research Abstract

Bisphosphonates are recently developed new drugs for the inhibition of bone resorption. In order to study the possible role of this drug in the dental field, a preliminary investigation was performed to clarify the effects of bisphosphonates on alveolar bone resorption process. For the experiments, an animal model for bone resorption induced by the low Ca diet was used and the histological changes were observed. Thirty days old male Wistar rats, mean body weight 70-85 g, were fed either normal calcium diet (0.5% Ca, 0.35% P, controls) or low Ca diet (0.05% Ca, 0.35% P, low Ca group) at the beginning of the experiment. These groups of rats were further divided into two groups and received daily by the subcutaneous injection of 1-hydroxyethyliedene-1,1-bisphosphonate (HEBP) at a dose of 4 mg/kg/day for 6 days. Control rats were received the same amounts of physiological saline. The rats were sacrificed at day 7 and undecalcified ground section of mandibular bone was examined. Contact microradiogram showed that trabecular bone located between the molar and incisor tooth were markedly resorbed in the low Ca group compared with the control group. HEBP inhibited the bone loss induced by the low Ca diet and the bone area and the mean bone width of alveolar bone increased. These changes of bone may be due to the inhibitory effects of dissolution of bone mineral and partially due to the inhibitory effects of bone resorption of HEBP. The present result suggests that bisphosphonates will be a novel drug for preventing the alveolar bone resorption in the dental field in future.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 大谷 啓一: "低カルシウム食飼育ラットの臼歯部歯槽骨吸収の遂行に関する研究" 口腔病学会雑誌. 59. 585-593 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大谷 啓一: "共焦点レーザー走査顕微鏡を用いた硬組織の形態学的観察" 歯科基礎医学会雑誌. 34. 339-349 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KEIICHI OHYA: "ALVEOLAR BONE RESORPTION PROCESS IN MOLAR TOOTH REGION IN CALCIUM-DEFICIENT RATS." THE JOURNAL OF THE STOMATOLOGICAL SOCIETY, JAPAN. VOL. 59. 585-593 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] KEIICHI OHYA: "MORPHOLOGICAL OBSERVATIONS OF THE HARD TISSUES WITH THE CONFOCAL LASER SCANNING MICROSCOPE." JAPANESE JOURNAL OF ORAL BIOLOGY. VOL. 34. 339-349 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 大谷 啓一: "低カルシウム食飼育ラットの臼歯部歯槽骨吸収の進行に関する研究" 口腔病学会雑誌. 59. 585-593 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 大谷 啓一: "共焦点レーザー走査顕微鏡を用いた硬組織の形態学的観察" 歯科基礎医学会雑誌. 34. 339-349 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Keiichi Ohya: "Ettects of HEBP on the experimental bone resorption in rat." J.Dent.Res.70. 577 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Keiichi Ohya: "Effects of 1ーhydroxyethyliedeneー1,1ーbisphosphorate(HEBP)on bove resorption induced by the low Ca diet in rats." Japan.J.Pharmacol.55. 133 (1991)

    • Related Report
      1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi