Insolubilization and Adhesive Properties of Biomimetic Collagen asan Artificial Periodontal Membrane

• Project/Area Number: 03670912
• Research Category: Grant-in-Aid for General Scientific Research (C)
• Allocation Type: Single-year Grants
• Research Field: 補綴理工系歯学
• Research Institution: Osaka University
• Principal Investigator: OKAZAKI Masayuki Osaka Univ. Fac of Dent. Assoc. Prof., 歯学部, 助教授 (30107073)
• Co-Investigator(Kenkyū-buntansha): YAMAGA T Osaka Univ. Fac of Dent. Assist. Prof., 歯学部・附属病院, 講師 (30127310) ; TERAOKA F Osaka Univ. Fac of Dent. Assist., 歯学部, 助手 (00099805) ; SOHMURA T Osaka Univ. Fac of Dent. Assist. Prof., 歯学部, 講師 (10154692) ; TAKAHASHI J Osaka Univ. Fac of Dent. Prof., 歯学部, 教授 (80029149) ; 木村 博 大阪大学, 歯学部, 教授 (70036218)
• Project Period (FY): 1991 – 1993
• Project Status: Completed (Fiscal Year 1993)
• Budget Amount: ¥1,700,000 (Direct Cost: ¥1,700,000); Fiscal Year 1993: ¥300,000 (Direct Cost: ¥300,000); Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000); Fiscal Year 1991: ¥1,100,000 (Direct Cost: ¥1,100,000)
• Keywords: Artificial Periodontal / Biomimetic / Collagen / Insolubilization / Bio-adhesion / UV照射 / コラ-ゲン / 波形デ-タ処理システム / バイオミメティックス

Research Abstract

Recently, our society is growing into and aged society. More people are losing their teeth and must use artificial prothetics such as dentures and artificial tooth roots. It is not easy to develop an excellent restorative material for periodontal membrane because the natural periodontal membrane contributes to connect tooth root and alveolar bone, and also acts as a xhock absorber for exterior force. The observation of the periodontal mebrane using scanning electron mictoscope clearly showed such complicate bio-adhesion. As the results of our investigation concerning the artificial periodontal membrane, insolubilixation of collagen and its adhesion to apatite-collagen composites were successfully achieved by UV-ray irradiation and plasma treatment. However, since adhesive strength and shape problem of artificial periodontal membrane-tooth root system have not been resolved. further investigations are in progress.

Research Products

• [Publications] M.Okazaki: "Crystallographic Morphology of Heterogeneous Fluoridated Carbonate Apatites" J Dent Res. 72. 1285-1290 (1993)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] M.Okazaki and H.Ohmae: "Insolubilized Properties of Collagen Membranes as an Artificial Periodontal Membrane and their Dynamic Estimation." Artificial Organ Today. (in press).
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] M.Okazaki: "Crystallographic Morphology of Heterogeneous Fluoridated Carbonate Apatites" J Dent Res. 72. 1285-1290 (1993)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] M.Okazaki and H.Ohmae: "Insolubilized Properties of Collagen Membranes as an Artificial Periodontal Membrane and their Dynamic Estimation" Artificial Organ Today. (in press).
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] M.Okazaki: "Crystallographic Morphology of Heterogeneous Fluoridated Carbonate Apatites" J Dent Res. 72. 1285-1290 (1993)
• [Publications] M.Okazaki and H.Ohmae: "Insolubilized Properties of Collagen Membranes as an Artificial Periodontal Membrane and their Dynamic Estimation" Artificial Organ Today. (in press).
• [Publications] 岡崎 正之,高橋 純造,木村 博: "不均質系Mg含有アパタイトの結晶学的性質" JJSMgR. 11. 59-69 (1992)
• [Publications] 岡崎 正之: "フッ素化アパタイトの結晶学的性質に及ぼすMg^<2+>,Fe^<2+>,CO_3^<2+>イオンの影響" 生体材料. 10. 247-255 (1992)
• [Publications] 岡崎 正之,高橋 純造,木村 博: "アパタイトの物理化学的性状におよぼすMg^<2+>,CO_3^<2ー>,F^-イオンの相互作用" マグネシウム. 10. 7-18 (1991)
• [Publications] M.Okazaki: "Crystallographic behaviour of fluoridated hydroxyapatites containing Mg^<2+> and CO_3^<2-> ions" Biomaterials. 12. 831-835 (1991)