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Bone formation by bone morphogenetic proteins under immune disorders

Research Project

Project/Area Number 03670935
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionTOHOKU UNIVERSITY

Principal Investigator

ECHIGO Seishi  Tohoku University, Department of Oral Surgery, Associate Prof., 歯学部口腔外科学第二講座, 助教授 (70005114)

Co-Investigator(Kenkyū-buntansha) MORI Shiro  Tohoku University, Dental Hospital, Assistant Prof., 歯学部附属病院, 助手 (80230069)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywordsimmune disorder / cytokine / bone morphogenetic protein / bone metabolism
Research Abstract

Bone formation is under the controls of cytokines in addition to several growth factors including bone morphogenetic proteins (BMPs), suggesting to be regulated by host immune response. To test whether immune disorders in the host influence the bone formation, we analyzed the BMPs-induced bone formation in several strains of mice bearing a single mutation gene; lymphoproliferation gene (lpr) or generalized lymphoproliferative disease gene (gld), which encodes lymphadenopathy, resulting in immune disorders. Crude BMPs derived from bovine bone were injected into femur muscle of these mice, and then quantitative analysis of the ectopic bone formation by using X-ray photography was performed. The expression of the gld gene and to lesser extent the lpr gene had striking potential to enhance the ectopic bone formation in a non-lupus-prone strain of mice, C3H/HeJ. However, in a lupus-prone strain of mice, MRL/MpJ, the lpr gene rather inhibited the ectopic bone formation, possibly due to the enhanced accumulation of osteoclasts histologically observed. These findings indicate that the BMPs-induced bone formation is influenced by immune disorders relevant to lymphoproliferation genes and genetic backgrounds.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report

URL: 

Published: 1991-04-01   Modified: 2016-04-21  

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