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Function and Morphologic Studies after Reconstructive Surgery for Oral Cancer.

Research Project

Project/Area Number 03670942
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MIYAKI Katsuaki  Kyoto Univ. Med. Faculty Instructor, 医学部, 助手 (50211595)

Co-Investigator(Kenkyū-buntansha) TSUBOI Y.  Kyoto Univ. Med. Faculty Instructor, 医学部, 助手 (60221420)
YOKOE Y.  Kyoto Univ. Med. Faculty Instructor, 医学部, 助手 (30211650)
FUJITA S.  Kyoto Univ. Med. Faculty Instructor, 医学部, 助手 (50228996)
CHEN L.  Kyoto Univ. Med. Faculty Instructor, 医学部, 助手 (50171963)
HYO Y.  Shiga Univ. of Med. Science Ass.Prof., 歯科口腔外科学講座, 助教授 (70115921)
Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1991: ¥1,300,000 (Direct Cost: ¥1,300,000)
KeywordsOral Cancer / Reconstructive Surgery / Immunohistochemical / Maxillofacial Prothodontic / Implant / 再建行
Research Abstract

The purpose of this research project is to evaluate for function and morphologic changes after reconstructive surgery for oral cancer. The present studies were carried out clinical evaluation and fundamental studies on animals, and to develop a new biomaterial for maxillofacial prothodontic.
The results obtained during the past two years are as follows: (1) The experimental study of free microvascular flap in rats demonstrated that the number of vessels at each end of the flap increased. The blood supply of the flap was evaluated by using histochemical approach. (2) Clinical evaluation for arterial flap conditions after reconstructive surgery in oral cancer have shown that radiation therapy which was given more than 40Gy adversely affect flap conditions(i.e. flap necrosis) for comparison with those of less 40Gy. It was obvious that heavily irradiated tissue were not satisfactory for flap transfer. (3) The function and morphologic changes after reconstructive surgery on oral cancer was insufficient results on clinical evaluation. (4) In order to develop a new biomaterial for maxillofacial prothodontic, the Ti film prepared by ion beam assisted deposition technique, because of good adhesion and uniformity can be considered as an appropriate biomaterial for coating of artificial implants such as bone and tooth root.

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 西村 毅: "下顎歯肉癌におけるX線骨吸収像と予後との関連について" 日本口腔外科学会雑誌. 37(4). 805-810 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 瀬上 夏樹: "舌癌の臨床病理学的検討-切除標本と術前臨床所見との比較" 頭顎部腫瘍学会雑誌. 17(2). 81-84 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 坪井 陽一: "多面再構築コンピューター断層撮影の骨内インプラント埋植術への応用" ザ・クインチッセンス. 10(9). 6-16 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 兵 行忠: "下唇に発生した腺様表胞癌に対するestlander法の即時再建への応用" 日本口腔外科学会雑誌. 37(11. 1882-1883 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 坪井 陽一: "顎顔面外傷に伴う歯牙欠損に審美および機能修復を目的としたOsseointegrated inplantの臨床応用" 整形・災害外科. 35(5). 355-359 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Nishimura,T., Yokoe,Y., Matsui,H., Adachi,H., Murakami,K., Hyo,Y., Iizuka,T.: "The relationship between radiographic feature and prognosis on squamous cell carcinoma of the lower gingiva." Jpn. J. Oral Maxillofac. Surg.37. 805-810 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Segami,N., Yokoe,Y., Nishida,M., Murakami,K., Hyo,Y., Iizuka,T: "Clinico-pathologic study on tongue cancer; Comparison between histological and preoperative finding." Japan Society for Head and Neck Cancer.17. 81-84 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tsuboi,Y., Kawamura,K., Nagoshi,K., Iizuka,T.: "Application of multiplanner reformation computed tomography(MPR-CT) for examination of dental implantation." The Quintessence. 10. 6-16 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Hyo,Y., Tsuboi,Y., Miyaki,K., Iizuka,T.: "Application of Estlander's method for reconstruction of adenoid cystic carcinoma on the lower lip:report of case." Jpn. J. Oral Maxillofac. Surg.37. 1882-1883 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Tsuboi,Y., Fujita,S., Iizuka,T., Takeshima,C.: "Esthetic and functional restoration using osseointegrated implants for the missing teeth in a patient with oral and maxillofacial injury." Orthp. Surg. Traumatol.35. 355-359 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] 西村 毅: "下顎歯肉癌におけるX線骨吸収像と予後との関連について" 日本口腔外科学会雑誌. 37(4). 805-810 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 瀬上 夏樹: "舌癌の臨床病理学的検討-切除標本と術前臨床所見との比較" 頭頸部腫瘍学会雑誌. 17(2). 81-84 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坪井 陽一: "多面再構類コンピューター断層撮影の骨内インプラント埋植術への応用" ザ・クインチッセンス. 10(9). 6-16 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 兵 行忠: "下唇の発生した腺様細胞癌に対するEsttander法の即時再建への応用" 日本口腔外科学雑誌. 37(11). 1882-1883 (1991)

    • Related Report
      1992 Annual Research Report
  • [Publications] 坪井 陽一: "歯類面外傷に伴う歯牙欠損に審美および概能修復を目的としたOsseointegrated implant の臨床応用" 整形・災害外科. 35(3). 355-359 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] 西村 毅: "下顎歯肉癌におけるX線骨吸収像と午後との関連について" 日本口腔外科学会雑誌. 37(4). 805-810 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 瀬上 夏樹: "舌癌の臨床病理学的検討ー切除標本と術前臨床所見との比較" 頭頸部腫瘍学会雑誌. 17(2). 81-84 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 坪井 陽一: "多面再構築コンピュ-タ断層撮影の骨内インプラント埋植術への応用" ザ・ワインテッセンス. 10(9). 6-16 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 兵 行忠: "下唇に発生した腺〓〓胞癌に対するEstlander法の即時再建への応用" 日本口腔外科学会雑誌. 37(11). 1882-1883 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 坪井 陽一: "顎顔面外瘍に伴う歯〓損に富美および機能修後を目的としたOsseantegrated implantの臨床応用" 整形.災害外科. 35(3). 355-359 (1992)

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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