| Project/Area Number |
03670984
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
小児・社会系歯学
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| Research Institution | TSURUMI UNIVERSITY |
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Principal Investigator |
OHNO Kohachiro TSURUMI UNIV., SCHOOL OF DENTAL MEDICINE,DEPARTMENT OF PEDIATRIC DENTISTRY ASSOCIATE PROFESSOR, 歯学部, 助教授 (70014206)
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| Project Period (FY) |
1991 – 1993
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| Project Status |
Completed (Fiscal Year 1993)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1993: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1992: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1991: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Defect of tooth structure / Developmental defect / Mechanism / Histological feature / Electron microscopic observation / Biochemical analysis |
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| Research Abstract |
The aim of this study was to investigate histologically and biochemically the mechanism of developmental defect of tooth structures. The materials were dental hard tissues which were respectively affected with hereditary ameloge nesis imperfeta, disorder of endocrine glands and odontodysplasia. The specimens prepared from the extracted teeth were observed optically as well as electton microscopically, and then tooth substances were analyzed chemically by using the enamel biopsy technique.
The results obtained were as follows : (1) A characteristic feature of the enamel structure of hereditary amelogenesis imperfecta was the globular type of mineralisation and Liesengang ring-like alternating layrs of mineral. TEM photograph showed two different sizes of crystals in the rod structures. (2) Calcitonin level in serum (287pg/ml) was specifically high in the case of disorder of endocrine glands. The histological observation was characteritic that any odontoclasts were not seen in the root resorption sites. (3) Inthe Ghost teeth of odontodysplasia, the mantle dentin in the crown was showed dysplasia, but the dentin in the root was normal.
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