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Development of effective drugs on impairments of Circardian rhythms and anticipatory behaivior in old rats.

Research Project

Project/Area Number 03671098
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 応用薬理学・医療系薬学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

SHIBATA Shigenobu  Dept. pharmacol. Fac. pharmaceut. Sci., Kyushu Univ., Assistant Professor., 薬学部, 助手 (10162629)

Project Period (FY) 1991 – 1992
Project Status Completed (Fiscal Year 1992)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1992: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1991: ¥1,600,000 (Direct Cost: ¥1,600,000)
KeywordsCiycadian Rhythm / Suprachiasmatic / Sleep-activity Rhythm / Cognition / Anticipation / Animal model / Acetylcholine / Cognitive enhancer / 向精神薬 / 体内時計 / サ-カディアンリズム / 夜間徘廻 / 抗痴呆薬 / 精神分裂病 / タンパク合成阻害薬 / 神経伝達物質
Research Abstract

The suprachiasmatic nucleus(SCN)has been identified as a pacemaker for mammalian circadian rhythms.Glutamate,substance P,NPY and GABA have been found to play an important role in the transmission of light information from retina to SCN.Therefore we investigated whether these chemicals can reset the phase of the circadian rhythms of SCN neuron activity.NMDA as glutamate receptor agonist and substance P produced phase changes similar to light-induced phase changes,while NPY and muscimolas a GABA receptor agonist produced those similar to dark-induced phase changes.If food is restricted to single meal scheduled at fixed time in the day,they will within a few days,exhibit a locomotor activity which anticipates mealtime.The anticipatory activity persists at its usual phase position when food is withheld for several days. At present,physical substrates necessary for food-entrainable rhythms are uncertain.This food-anticipatory activity was impaired by aging and a treatment with MK801,NMDA receptor antagonist.The impairment of this anticipatory activity was improved by the cotreatment with arecoline a cholinergic drug and bifemelane,a cognitive enhancer.These results suggest that deficit of anticipatory behavior may be a useful model of a deficit of "social entrainment".

Report

(3 results)
  • 1992 Annual Research Report   Final Research Report Summary
  • 1991 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Shigenobu Shibata: "Effect of substance P on circadian shythms of firing activity and 2-DG uptuhe in the rat supra chiasmatic nucleus in vitro." Brain Research. 597. 257-263 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Aguilar-Roblero,R.,: "Morphological and functional development of the suprachiaamatic nucleus in transplanted fetal hypothalamus." Brain Research. 580. 288-296 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Keiko Tominaga: "Effects of inhibitory and excifatony dwgson the netabolic ahythun of the hamster suprachiasnatic nucleus in vitro" Europ,J.Pharmacalogy. 217. 79-84 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata: "Excitafory effect of NMDA and Kainate receptor on the 2-DG uptake in the rat suprachiasmatic nucleus in vitro" Neuroscience Letters. 139. 83-86 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata: "An in vitro circadian shyihnn of protein synihesis in the rat SCN under tissue culture conditions" Brain Research.584. 251-256 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata: "Phase-resetting effect of 8-OH-DPAT a serotonin 1A receptor agonist on the circadian ihythnn of firing rate in the rat SCN in vitro" Brain Research.582. 353-356 (1992)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata: "NSF-Tokyo Symposium on Biological Timing 「Involvement of NMDA receptor mechaniom in the regulation of circadian clock fanction of the suprachiasmatic nucleus in vitro」" Elsevier., 5 (1993)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata,Atsuko Tsuneyoshi,Toshiyuki Hamada,Keiko Tominaga and Shigenori Watanabe: "Effect of substance P on circadian rhythms of firing activity and 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro." Brain Res. 597. 257-263 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] R.Aguilar-Roblero,R.,S.Shibata,J.C.Speh,R.Drucker-Colin and R.Y.Moore: "Morphological and functional development of the suprachiasmatic nucleus in transplanted fetal hypothalamus." Brain Res. 580. 288-296 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Keiko Tominaga,Shigenobu Shibata,Showa Ueki and Shigenori Watanabe: "Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters." Eur.J.Pharmacology. 214. 79-84 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Keiko Tominaga,Shigenobu Shibata,Showa Ueki and Shigenori Watanabe: "Effects of inhibitory and excitatory drugs on the metabolic rhythm of the hamster suprachiasmatic nucleus in vitro." Eur.J.Pharmacology. 217. 79-84 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata,Keiko Tominaga,Toshiyuki Hamada and Shigenori Watanabe: "Excitatory effect of N-methyl-D-aspartate and kainate receptor on the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro." Neuroscience Letters. 139. 83-86 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata,Toshiyuki Hamada,Keiko Tominaga and Shigenori Watanabe: "An in vitro circadian rhythm of protein synthesis in the rat suprachiasmatic nucleus under tissue culture conditions." Brain Res. 584. 251-256 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata,Atsuko Tsuneyoshi,Toshiyuki Hamada,Keiko Tominaga and Shigenori Watanabe: "Phase-resetting effect of 8-OH-DPAT,a serotoninlA receptor agonist,on the circadian rhythm of firing rate in the rat suprachiasmatic nuclei in vitro." Brain Res. 582. 353-356 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1992 Final Research Report Summary
  • [Publications] Shigenobu Shibata: "Effect of Substance P on circadian shythms of firing activity and the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro" Brain Research. 597. 257-263 (1992)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shigenobu Shibata: "Tetrodotoxin does not affect circadian rlythwrs in neuronal activity and metabolism in rodent suprachiasmatic nudous in vitro" Brain Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] Shigenobu Shibata: "Neuropeptide Y and optic nerve stimulation affect circadian function of rat suprachiasnatic nucleus neuions in vitro" Brain Research. (1993)

    • Related Report
      1992 Annual Research Report
  • [Publications] 柴田 重信,冨永 恵子: "生物のサ-カディアンリズムー3,高等動物" 化学と生物. 29. 124-131 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 柴田 重信,冨永 恵子: "哺乳動物の脳内神経機構とサ-カディアンリズム" 薬学雑誌. 111. 270-283 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 柴田 重信: "高等動物の生物時計" 植物細胞工学. 3. 449-457 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Tominaga,S.Shibata S.Ueki,S.Watanabe: "Effects of 5ーHT_<1A>abonists on the incadian shythm of wheelーrunning activity in hamsters." European Journal of Phrmacalogy.

    • Related Report
      1991 Annual Research Report
  • [Publications] K.Tominaga,S.Shibata S.Ueki,S.Watanabe: "Effects of inhibitory and excitatory drugs on the metabolic rhythm of hamster suprachiasmatie nucleus in vitro." European Journal of pharmacology.

    • Related Report
      1991 Annual Research Report
  • [Publications] S.Shibata,K.Tominaga T.Hamada,S.Watanabe: "Excitatory effect of NMDA and KA receptor agonists on the 2ーcleoxyglucose uptake in the rat suprachiasmatic nucleus in vitro" Neuroscience Letters.

    • Related Report
      1991 Annual Research Report

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Published: 1991-04-01   Modified: 2016-04-21  

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