| Project/Area Number |
03671107
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Hamamatsu University, School of Medicine. |
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Principal Investigator |
KANNO Takashi Hamamatsu University, School of Medicine Department of Laboratory Medicine, Professor,, 医学部, 教授 (70051406)
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| Project Period (FY) |
1991 – 1992
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| Project Status |
Completed (Fiscal Year 1992)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1992: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1991: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | Cytosolic aminopeptidase / Viral infection / Measles / Rubella / Erythema infectiosum / Lactate dehydrogenase / アミノペプチダーゼ / ウィルス性疾患 / 可溶性アミノペプチダ-ゼ |
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| Research Abstract |
I investigated clinical significance of serum cytosolic aminopeptidase(C-AP) as an early parameters for viral infection. I observed marked increases of serum C-AP in patients with Measles, Rubella, erythema infectiosum, and enteritis due to viral infection such as Rotavirus. These increases of serum C-AP associated with the increases of serum lactate dehydrogenase (LDH) especially LDH-II and LDH-III in isoenzyme analysis.
On the other hand, I observed significant increases of both C-AP and LDH activities in mitogen-stimulated T lymphocytes. These results indicate that the increase of C-AP brought by viral stimulation for T-lymphocyte reflects on the increase of C-AP in patients' serum, and that the increase of C-AP in serum is useful indicator for viral infections such as Measles and Rubella. However, no increases of C-AP was observed in Influenza infection.This difference is interest in the relation with the difference of target cell in viral infection.
As a result, it was demonstrated that the increase of serum C-AP is useful as an early parameter for the viral infection such as Measles, Rubella, and erythema infectiosum.
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